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Name: 5-Fluoro-2'-Deoxyuridine
Chemical Formula: C9H11FN2O5
CAS Number: 50-91-9
Synonyms: FdUrd, FUDR
Appearance: White to off-white crystalline powder
Common Uses: Cancer research, chemotherapeutic agent, lab reagent
Odor: Odorless
Primary Hazards: Harmful if swallowed, harmful in contact with skin, causes damage to organs through prolonged or repeated exposure, may cause skin and serious eye irritation, creates reproductive and developmental risk
Pictogram: Health hazard, exclamation mark
Acute Toxicity: Confirmed toxic to humans, especially with significant or chronic exposure
Risk for Laboratory Workers: Accidental spills or airborne dust pose exposure risk
Main Component: 5-Fluoro-2'-Deoxyuridine
Concentration: Over 95% purity is standard in lab settings
Inhalation: Move person to fresh air and seek immediate medical care if symptoms appear
Skin Contact: Wash thoroughly with soap and water for at least 15 minutes and remove contaminated clothing
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, seek medical attention
Ingestion: Do not induce vomiting, rinse mouth, get medical help without delay
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Hazardous Combustion Products: Emits toxic fumes of fluorine, carbon monoxide, carbon dioxide, nitrogen oxides when burned
Special Protective Equipment: Full protective gear and self-contained breathing apparatus
Additional Fire Info: Avoid inhaling fumes, evacuate area if safe to do so, keep containers cool
Personal Precautions: Avoid dust, ventilate area, wear suitable protective equipment
Environmental Precautions: Prevent entry into drains, soil, or waterways
Methods for Cleanup: Scoop or sweep up using tools that avoid raising dust, place in properly labeled container for disposal, clean surfaces thoroughly to remove residue
Handling: Always use in a chemical fume hood or ventilated area, avoid skin contact, wash hands after handling
Storage: Store in a tightly closed, clearly marked container, shield from light and moisture, keep in a cool and dry place
Incompatible Materials: Strong oxidizing agents, bases
Engineering Controls: Work in well-ventilated areas, use fume hood for all manipulations
Personal Protection: Gloves resistant to chemicals, safety glasses with side shields, lab coat, closed shoes, and, if dust risk is high, NIOSH-certified respirator
Hygiene Measures: Avoid eating, drinking, or smoking in the work area, wash hands after handling and before breaks, keep work clothes separate from personal clothing
Appearance: Solid, white to off-white powder
Molecular Weight: 246.19 g/mol
Solubility: Water soluble
Melting Point: Ranges from 160 to 164°C
Odor: Odorless, tasteless
pH: Neutral to slightly acidic when dissolved in water
Stability: Stable under recommended storage and handling conditions
Sensitivity: Degrades with heat, moisture, or light exposure
Decomposition Products: Toxic gases including fluorinated compounds and nitrogen oxides
Reactive With: Strong oxidizers, strong bases
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Acute Effects: Nausea, vomiting, skin and mucous membrane irritation, respiratory difficulty
Chronic Effects: Damages bone marrow, reproductive organs, and can cause developmental toxicity, potential mutagenic risk
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a confirmed carcinogen, but mutagenic and teratogenic properties established
Users at Risk: Pregnant individuals, those with compromised immunity are more vulnerable
Aquatic Toxicity: Data is limited, but chemical agents in this class are persistent and harmful to aquatic life
Persistence and Degradability: Likely slow degradation in natural environments due to stability
Bioaccumulation: No specific bioaccumulation reported, but recommended to avoid environmental release
Chemical Waste: Collect and dispose as hazardous waste following local, state, and federal guidelines
Container Disposal: Empty containers retain product residue; handle as hazardous material
Precautions: Do not pour chemical down the drain or dispose with regular trash
Best Practices: Employ trained hazardous waste handlers for disposal
Shipping Regulations: Subject to strict guidelines for transport, calls for labeling as toxic
Proper Packaging: Use approved, sealed, and durable containers
Hazard Class: Classified as hazardous for air and land shipments
Spill Response During Transport: Emergency response plan must be in place for accidents
Government Oversight: Recognized as hazardous material under OSHA, potentially regulated by other country authorities
Worker Safety: Employees working with 5-Fluoro-2'-Deoxyuridine receive workplace safety training and hazard communication
Universal Precautions: Follow established exposure limits, safety guidelines, regular hazard assessments in research and industry
Consumer Use: Not approved for general consumer use; regulated strictly to prevent accidental exposure or misuse
