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Product Name: Uracil
Chemical Formula: C4H4N2O2
Molecular Weight: 112.09 g/mol
CAS Number: 66-22-8
Synonyms: 2,4-Dihydroxypyrimidine; 2,4-Pyrimidinedione
Recommended Use: Laboratory and research applications, pharmaceutical intermediate
Supplier Details: Full company address, contact number, and emergency phone, always clearly visible on original shipping documentation for traceability
Emergency Contact: National chemical emergency hotline and internal responsible safety personnel
GHS Classification: Not classified as a hazardous substance or mixture based on GHS criteria
Signal Word: None required under GHS
Hazard Statements: Not considered hazardous under normal conditions of use, still prudent handling necessary to protect workers and environment
Potential Health Effects: Prolonged skin or eye contact could cause irritation. Dust inhalation could be irritating to respiratory tract, especially in poorly ventilated spaces. Ingestion in large amounts could cause stomach upset or discomfort
Precautionary Statements: Avoid breathing dust; wash thoroughly after handling; wear safety glasses, gloves, and lab coat
NFPA Ratings: Health: 1, Flammability: 0, Reactivity: 0
Chemical Name: Uracil
CAS Number: 66-22-8
Concentration: 100% pure substance
Impurities: Trace organic or inorganic contaminants possible; quality control documents report impurity levels below 0.1% for lab and pharmaceutical grade
Skin Contact: Remove contaminated clothing; flush skin with running water and gentle soap for at least 15 minutes. Seek medical advice if irritation continues.
Eye Contact: Rinse eyes gently but thoroughly with water for a minimum of 15 minutes, lifting upper and lower eyelids. Remove contact lenses if present and easy to do. Medical attention is a good choice for persistent irritation.
Inhalation: Move individual to fresh air right away. Keep at rest in a position comfortable for breathing. Qualified medical evaluation recommended for ongoing discomfort, coughing, or breathing problems.
Ingestion: Rinse mouth with water, spit out rinse, and seek medical help if large quantities consumed or symptoms develop. Do not induce vomiting unless instructed by healthcare professional.
Notes for Medical Personnel: Symptomatic management, support respiratory and cardiac function if needed, monitor for secondary complications
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, or foam. Use extinguishing agent suitable for the surrounding fire.
Unsuitable Media: Direct water jet at pressurized dust clouds (may spread powder particles)
Specific Hazards: Product may emit nitrogen oxides, carbon monoxide, carbon dioxide when involved in a fire. Dust may contribute to local irritation.
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear. Isolate hazard area, evacuate personnel from vicinity beyond immediate danger
Special Fire Procedures: Prevent run-off to drains and waterways. Contain and collect water used to fight fire for proper disposal. Stay upwind of smoke.
Personal Precautions: Wear NIOSH-certified dust mask or respirator, safety goggles, gloves, and protective clothing. Avoid formation and inhalation of dust. Evacuate area if necessary based on scale of release.
Environmental Precautions: Prevent further leakage or spillage if safe to do. Do not allow material to enter drains, surface water, or soil.
Containment: Sweep or vacuum up spilled material using equipment fitted with HEPA filter. Avoid raising dust clouds. Collect residue in labeled non-sparking plastic containers for disposal.
Cleaning: Rinse area with water, ventilate, and air dry afterwards. Dispose according to local regulations
Handling: Handle in well-ventilated workspaces, use local exhaust to minimize dust or fumes. Avoid dust buildup and static discharge. Do not eat, drink, or smoke in working areas. Wash hands thoroughly after handling. Remove contaminated clothing and protective equipment before entering eating spaces.
Storage: Store in airtight containers, in a cool, dry, and well-ventilated place. Keep away from incompatible materials including strong oxidizers and acids. Secure containers to prevent accidental spills.
Occupational Exposure Limits: No established OELs for uracil as of current regulatory guidelines. Use established good laboratory practices for nuisance dust (typically 10 mg/m³ total, 3 mg/m³ respirable as per ACGIH TLV for particulates not otherwise classified)
Engineering Controls: Use local exhaust or general dilution ventilation to keep airborne dust concentrations low.
Personal Protective Equipment: Safety goggles or face shield for eyes; chemical-resistant gloves for skin; long-sleeved laboratory coat or coverall; approved NIOSH respirator recommended for heavy dust concentrations
Hygiene Measures: Wash thoroughly after handling and before breaks; keep workspaces clean to lower accident risk.
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Slightly acidic when dissolved in water (pH 5-6)
Melting Point/Freezing Point: 335 °C (635 °F)
Boiling Point/Range: Decomposes before boiling
Solubility: Slightly soluble in cold water; more soluble in hot water, ethanol
Partition Coefficient (n-octanol/water): Log Kow: -1.07
Vapor Pressure: Not measurable at room temperature
Density: 1.32 g/cm³
Evaporation Rate: Not volatile
Flammability: Non-flammable solid
Explosive Properties: Not explosive
Auto-ignition Temperature: Not available
Decomposition Temperature: About 335 °C
Chemical Stability: Chemically stable under recommended storage and handling conditions
Reactivity: Does not react rapidly with air, water, or neutral substances
Hazardous Reactions: No hazardous polymerization reported. May react with strong oxidizing agents, strong acids
Conditions to Avoid: Storage with heat sources, open flame, moisture, or incompatible chemicals. Avoid grinding that creates large clouds of dust.
Incompatible Materials: Strong oxidizers, strong acids. Avoid co-storage with compounds that could promote degradation.
Decomposition Products: Thermal breakdown may release nitrogen oxides, carbon oxides, and ammonia
Acute Toxicity: Oral LD50 in rats exceeds 5000 mg/kg; not considered acutely toxic. Inhalation and dermal toxicity low based on animal studies.
Chronic Exposure: No long-term health issues or carcinogenicity identified in available animal studies; not listed as carcinogen by IARC, NTP, OSHA
Skin and Eye Irritation: May cause mild irritation in some individuals on prolonged contact. Not sensitizing.
Inhalation: Dust may cause irritation to mucous membranes or breathing passages in some workers.
Ingestion: Large amounts may provoke nausea or stomach discomfort, not expected to cause severe toxicity.
Reproductive / Developmental Toxicity: No known effects reported based on available data.
Mutagenicity / Genotoxicity: No evidence for mutagenic activity in standard tests.
Eco-Toxicity: No acute or chronic aquatic toxicity reported at concentrations expected in environment. Non-toxic to fish, daphnia, and algae based on published studies.
Persistence and Degradability: Readily biodegradable under aerobic conditions.
Bioaccumulation: Low potential for bioaccumulation, log Kow below zero.
Mobility in Soil: High; water soluble and subject to movement to ground and surface water.
Other Environmental Concerns: Proper containment is better than release. No major environmental hazards identified for small, normal lab volumes
Product Disposal: Collect and dispose of according to local, state, and national regulations as non-hazardous solid waste if uncontaminated. Mixing with general refuse discouraged.
Contaminated Packaging: Empty packaging and liners should be disposed of as clean industrial waste or recycled after thorough cleaning. If contaminated with hazardous materials, handle according to hazardous waste protocols.
Sewage Disposal: Releasing significant amounts into the sewage system not recommended
Special Disposal Notes: Small quantities from research operations often collected for periodic hazardous waste disposal; larger quantities from manufacturing follow waste manifest documentation
UN Number: Not assigned (material not regulated for transport by air, land, or sea)
Proper Shipping Name: Uracil
Transport Hazard Class: Not hazardous under international transport regulations
Packing Group: None
Environmental Hazards: Not environmentally hazardous for transport
Special Precautions for Transport: Keep container tightly closed, secured upright. Ship in labeled containers, avoid physical damage during transit.
TSCA (US): Listed
REACH (EU): Exempt as non-hazardous research/biochemical chemical; listed for full registration if imported or produced at high volumes
SARA Title III: Not subject to specific reporting. Not a known Extremely Hazardous Substance
California Prop 65: Not listed as a carcinogen or reproductive hazard
Canada DSL/NDSL: Included on the DSL
Other Notice: Not subject to specific workplace hazard labeling under OSHA HazCom rules for non-hazardous materials, good laboratory practice still required with any chemical
