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Product Name: Tween 80
Chemical Name: Polysorbate 80
Synonyms: Polyoxyethylene (20) sorbitan monooleate
CAS Number: 9005-65-6
Recommended Uses: Emulsifier in pharmaceuticals, food, cosmetics, and laboratory applications
Supplier Details: Manufacturer or distributor contact information provided on packaging
Emergency Contact: Refer to regional poison centers or emergency numbers included by supplier
Classification: Not classified as hazardous under GHS
Label Elements: No symbol required, may involve warnings for skin and eye irritation in sensitive individuals
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Possible Health Effects: Mild irritation to skin and eyes, possible allergic reactions in predisposed personnel
Environmental Impact: Low acute aquatic toxicity, avoid uncontrolled releases
Main Component: Polysorbate 80 (≥ 98%)
Impurities: Residual ethylene oxide (trace), fatty acid esters (trace)
Chemical Formula: C64H124O26
Molecular Weight: Approximately 1310 g/mol
Inhalation: Move to fresh air, support breathing as needed
Skin Contact: Wash affected area with water and mild soap, remove contaminated clothing
Eye Contact: Rinse cautiously with water for several minutes, seek medical advice if irritation continues
Ingestion: Rinse mouth with water, never induce vomiting unless instructed by poison control, get medical attention for large amounts or symptoms
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Specific Hazards: May emit carbon oxides on burning
Protective Equipment: Standard firefighting gear, self-contained breathing apparatus for large fires
Thermal Decomposition: Produces irritating or toxic fumes including carbon monoxide and dioxide
Personal Precautions: Wear gloves, goggles, and appropriate clothing
Environmental Precautions: Prevent runoff into drains, soils, or waterways
Spill Cleanup: Contain material using inert absorbent, scoop into containers for disposal, flush area with water, ventilate confined areas
Handling: Avoid contact with eyes, skin, or clothing, practice good hygiene after use
Storage: Store in closed containers, keep in cool, dry, well-ventilated space, protect from excessive heat and direct sunlight, keep away from strong oxidizers, observe shelf life dates
Exposure Limits: No occupational exposure limits set for this product
Engineering Controls: Maintain adequate ventilation, use process enclosures if necessary
Personal Protection: Wear safety glasses, gloves, and protective lab coat, use respiratory protection if dust or mist is present
Hygiene Measures: Always wash hands after handling, remove contaminated clothing before breaks or meals
Appearance: Viscous, pale yellow liquid
Odor: Mild characteristic
pH: 6.0–8.0 (10% solution)
Melting Point: Near 0°C
Boiling Point: Not defined (decomposes before boiling)
Flash Point: Above 94°C (closed cup)
Solubility: Miscible in water, soluble in ethanol, insoluble in mineral oils
Density: About 1.06 g/mL at 25°C
Viscosity: High
Partition Coefficient: Not available
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: Low reactivity, but avoid strong acids, bases, and oxidizing agents
Hazardous Reactions: None expected under normal conditions
Decomposition Products: Carbon monoxide, carbon dioxide, possibly small amounts of other toxic fumes if heated strongly
Polymerization: Will not occur
Acute Toxicity: Low oral, dermal, and inhalation toxicity (oral LD50 in rats ≈ 25 g/kg)
Skin Irritation: May cause mild irritation with prolonged exposure
Eye Irritation: May cause mild irritation
Sensitization: Rarely reported
Chronic Effects: No evidence of carcinogenic, mutagenic, or reproductive toxicity in published studies
Target Organs: None identified in normal usage
Aquatic Toxicity: Low toxicity to aquatic organisms
Persistence and Degradability: Biodegradable, breaks down under environmental conditions
Bioaccumulation Potential: Low, does not significantly concentrate in organisms
Soil Mobility: Expected to have moderate mobility in soil
Other Adverse Effects: Limited information indicates little long-term ecological harm
Disposal Methods: Dispose in accordance with local, regional, or national regulations; incinerate or landfill as permitted
Container Disposal: Triple-rinse containers, recycle or dispose as non-hazardous waste if regulations allow
Do Not: Discharge to watercourses, sewers, or open environments without treatment
UN Number: None assigned (not regulated as a dangerous good)
Proper Shipping Name: Not regulated
Transport Hazard Class: Non-hazardous for ground, sea, and air transport
Packing Group: Not applicable
Special Precautions: Protect from physical damage, seal containers during transit, prevent leaks
GHS Status: No classification required for health or physical hazards
TSCA (USA): Listed
REACH (EU): Registered
Other Listings: Included in inventories for Canada, Australia, Japan, China, and other regions
Labeling Requirements: None under current international transport or workplace regulations; handling guidance, general precautionary statements encouraged
