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Product Name: Tunicamycin
Chemical Family: Nucleoside antibiotic mixture
CAS Number: 11089-65-9
Synonyms: TU, TM, Nucleoside antibiotic
Recommended Use: Laboratory research, biochemical studies, inhibitor of N-linked glycosylation
Supplier Information: Manufacturer and contact details listed on shipping documentation
Emergency Contact: Numbers available via workplace supervisor or institutional protocols
Classification: Acute Toxicity (Oral) Category 3, Acute Toxicity (Inhalation, Dermal) Category 3, Eye Damage/Irritation Category 2A, Skin Sensitizer Category 1
Signal Word: Danger
Hazard Statements: Toxic if swallowed, inhaled, or absorbed through skin. Causes serious eye irritation. May cause allergic skin reaction.
Pictogram: Skull and crossbones, exclamation mark
Precautionary Statements: Do not breathe dust. Avoid contact with skin, eyes, clothing. Use only in fume hood or ventilated area. Wear nitrile gloves, lab coat, eye protection. Wash exposed body parts thoroughly after handling. Do not eat, drink, or smoke during use.
Chemical Name: Tunicamycin
Concentration: ≥95%
CAS Number: 11089-65-9
Impurities: Trace variants of tunicamycins (molecular variants A, B, C, D, I, V, X)
Molecular Formula: C38H64N4O16
Molecular Weight: Approx. 856-902 g/mol (mixture)
Inhalation: Move person to fresh air. Seek immediate medical attention. If breathing stops, perform artificial respiration and provide oxygen if available.
Skin Contact: Remove contaminated clothing. Rinse affected skin area under running water for 15 minutes. Seek medical advice if irritation persists.
Eye Contact: Rinse eyes cautiously with water for several minutes, lifting eyelids. Remove contact lenses if present and easy to do. Continue rinsing. Consult ophthalmologist if irritation persists.
Ingestion: Rinse mouth, never give anything by mouth to an unconscious person. Do not induce vomiting; seek medical attention immediately.
Note to Physicians: Treat symptomatically and supportively; product poses risk of acute toxicity and potential allergy.
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray to cool containers
Unsuitable Extinguishing Media: Direct water jet can scatter material
Specific Hazards Arising from Substance: Emits toxic fumes (carbon monoxide, nitrogen oxides) under fire; dust may form explosive mixture with air
Protective Equipment for Firefighters: Self-contained breathing apparatus, protective suit with gloves and boots; avoid exposure to smoke
Special Procedures: Move containers from fire area if safely possible, avoid contaminated runoff
Personal Precautions: Use full personal protective equipment including eye protection, gloves, and respirator in case of high dust levels. Avoid dust formation and breathing vapors.
Environmental Precautions: Do not let product enter drains, sewers, or natural water sources. Prevent further leakage if safe to do so.
Methods for Cleaning Up: Sweep up and shovel within chemical fume hood. Use moistened absorbent material to avoid dust. Dispose of collection in closed chemical waste containers. Ventilate area and wash spill site with soap and water after pickup is complete.
Precautions for Safe Handling: Handle in certified chemical fume hood, wear gloves, lab coat, and protective eyewear. Minimize dust production, avoid skin and respiratory contact. Wash hands before breaks and at end of work. Prohibit eating, drinking, and smoking in area. Keep away from incompatible materials—strong oxidizers and acids.
Conditions for Safe Storage: Store at -20°C, tightly closed in original labeled container. Protect from light, heat, and excessive moisture. Segregate from incompatible substances. Comply with institutional protocols for toxic chemical storage. Label all storage vessels clearly.
Engineering Controls: Use only in approved chemical fume hood, handle with local exhaust ventilation. Install eyewash and emergency shower nearby.
Personal Protective Equipment: Chemical splash goggles or face shield, long-sleeved lab coat, nitrile or chemical-resistant gloves, disposable shoe covers if handling quantities. Use fit-tested respirator (NIOSH-approved) if dust or vapor exposure risk increases.
Hygiene Measures: Clean work surfaces frequently and thoroughly. Remove gloves and lab clothing carefully to prevent contamination. Dispose of contaminated protective wear according to local regulations.
Appearance: Off-white or yellowish powder or lyophilized solid
Odor: Odorless or faint typical organic smell
pH: Not applicable (insoluble in water at high concentrations; forms suspensions in ethanol, methanol, DMSO)
Melting Point: Decomposes above 180°C (exact melting point not well established)
Boiling Point: Not available (decomposes before boiling)
Solubility: Soluble in methanol, ethanol, DMSO; sparingly soluble in water
Vapor Pressure: Not available
Density: Not determined
Flash Point: None (non-volatile solid)
Partition Coefficient (n-octanol/water): Not determined
Chemical Stability: Stable under recommended conditions, sensitive to light and moisture, degrades in presence of acids, bases, oxidizers
Conditions to Avoid: Heat, light, open air, incompatible chemicals—strong acids, bases, oxidizers
Incompatible Materials: Strong oxidants, acids, bases
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, toxic organics in decomposition
Hazardous Polymerization: Does not polymerize under normal storage or use
Acute Toxicity Data: Oral LD50 (mouse) ≈ 1-3 mg/kg; very little margin of safety in mammals
Chronic Effects: No chronic toxicity data available in humans, evidence of developmental and reproductive toxicity in animal studies
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Symptoms: Irritation to eyes, nose, throat, and skin; systemic toxicity—nausea, vomiting, convulsions, breathing difficulty
Carcinogenicity: No data; not listed as carcinogen by IARC, NTP, or OSHA
Sensitization: May cause allergic skin responses on repeated exposure
Mutagenicity/Teratogenicity: Shows embryotoxic and teratogenic effects in animal systems
Medical Conditions Aggravated: Pre-existing skin, eye, or respiratory disorders may worsen with exposure
Ecotoxicity: Harmful to aquatic organisms owing to antibiotic activity
Persistence and Degradability: Expected to degrade slowly in environment, exact pathways uncharacterized
Bioaccumulative Potential: Low potential for bioconcentration, but antibiotic effects concern food web
Mobility in Soil: Low to moderate, substance may bind to organic matter or leach with water
Other Adverse Effects: Can disrupt soil and aquatic microorganism populations, harming ecological balance
Precautions: Avoid introduction into surface water, soil, and sewage systems
Methods of Disposal: Dispose of tunicamycin as hazardous laboratory waste, follow national and institutional guidelines
Packaging: Place in appropriate, sealed, and labeled chemical waste containers
Contaminated Packaging: Treat as hazardous waste, dispose of via chemical waste contractor
Environmental Disposal: Do not discharge to drains, aquatic environment, or general trash
Regulatory Information: Comply with national, regional, and local hazardous waste regulations
UN Number: Not assigned (in most jurisdictions, not classified for transport hazard)
Transport Hazard Class: Not classified
Packing Group: Not classified
Proper Shipping Name: Laboratory chemicals, n.o.s. (not otherwise specified)
Labeling Requirements: Mark as hazardous laboratory chemical, ensure secure packaging
Special Precautions: Avoid accidental spills during packing and transit, alert carrier to toxic nature if shipped
TSCA Status: Not listed on U.S. TSCA inventory, research use only
REACH Restrictions: Not registered for commercial use in the EU, laboratory use only
US Federal Regulations: Not specifically regulated as a listed substance, handle as hazardous under OSHA
California Prop 65: Not listed
EU Classification: Toxic (T), Harmful (Xn), Sensitizer (Xi)—under Classification, Labeling and Packaging (CLP) Regulation
Other Safety, Health, and Environment Regulations: Must follow local, state, and institutional safety protocols for toxic chemical agents
