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Product Name: Tris Hydrochloride (Tris-HCl)
Chemical Formula: C4H11NO3·HCl
Synonyms: Tris(hydroxymethyl)aminomethane hydrochloride, Tris HCL Buffer
CAS Number: 1185-53-1
Recommended Uses: Laboratory reagents, buffer solutions
Supplier Details: Manufacturer and authorized distributor contact information as listed on the label or safety sheet
Emergency Contact: National Poison Center or manufacturer’s emergency number
GHS Classification: Not classified as hazardous under GHS criteria for most concentrations used in laboratories
Signal Word: None required
Hazard Statements: May cause mild eye, skin, or respiratory irritation:
Symptom Information: Eyes may experience redness or wateriness, skin may feel dry after exposure, inhalation of dust might trigger coughing
Pictograms: No pictograms required for non-hazardous classification at typical concentrations
Chemical Identity: Tris(hydroxymethyl)aminomethane hydrochloride
CAS Number: 1185-53-1
Concentration: 98-100% (w/w) as solid, dilute in aqueous buffers as specified by use
Impurities: No known dangerous impurities present in analytical grade material
Inhalation: Move person to fresh air, monitor for respiratory irritation or discomfort, seek medical attention if symptoms persist
Eye Contact: Rinse eyes gently with clean water for at least 15 minutes, avoid rubbing eyes during washing, seek medical advice for any persistent pain or symptoms
Skin Contact: Wash contaminated skin thoroughly with water and mild soap, remove contaminated clothing, seek attention for unresolved irritation or allergic response
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical attention if large amounts are swallowed or if gastrointestinal discomfort develops
Suitable Extinguishing Media: Water spray, foam, dry chemical, or CO2 as appropriate for surrounding materials
Specific Hazards: Product is not combustible, may decompose on strong heating to release vapors of nitrogen oxides, carbon dioxide, or hydrochloric acid
Protective Equipment: Wear self-contained breathing apparatus and protective gear suitable for the surrounding fire environment
Firefighting Instructions: Avoid direct contact with decomposition products, prevent runoff from contaminating waterways, use water to cool exposed containers
Personal Precautions: Wear safety glasses, gloves, and dust mask to reduce immediate contact risks
Environmental Precautions: Prevent contamination of drains, waterways, and soil by containing the spilled solid or solution with suitable absorbent materials
Clean-up Methods: Sweep or vacuum spillage without generating dust; transfer waste to a properly labeled container for disposal, wash area with water after clean-up
Handling: Minimize dust formation through careful transfer, ensure good ventilation or localized extraction in work area, avoid direct skin and eye contact
Storage: Keep container tightly closed in a dry, cool, well-ventilated, and designated chemical storage area, separate from strong acids and oxidizers
Storage Temperature: Store at room temperature away from heat and humidity
Specific Requirements: Use clearly labeled containers and keep away from food, beverages, or incompatible reagents
Occupational Exposure Limits: No specific OSHA, NIOSH, or ACGIH exposure limit established
Engineering Controls: Work with material in fume hood or under suitable ventilation if dust risk present
Personal Protective Equipment: Wear laboratory gloves (nitrile or latex), chemical splash goggles, and a laboratory coat
Hygiene Measures: Wash hands thoroughly after handling, take care to avoid contact with face, work clothing should not be worn outside of laboratory
Appearance: White crystalline powder or granules
Odor: Odorless
Odor Threshold: Not applicable
pH (1% Solution): 4.5 - 6.0
Melting Point: 150 - 152 °C (decomposes)
Boiling Point: Not determined (decomposes before boiling)
Solubility: Highly soluble in water
Vapor Pressure: Not applicable
Partition Coefficient (n-octanol/water): Not determined
Relative Density: ~1.14 g/cm³
Flash Point: Not applicable (not flammable)
Evaporation Rate: Not applicable
Explosive Properties: Not explosive
Chemical Stability: Stable at standard temperature and pressure
Reactivity: Non-reactive under recommended handling and storage conditions
Incompatible Materials: Strong oxidizers, strong acids; avoid mixing with reactive chemicals
Decomposition Products: On heating, may emit toxic fumes of nitrogen oxides, carbon oxides, and hydrochloric acid
Conditions to Avoid: Exposure to excessive heat, prolonged storage in humid or wet conditions
Acute Toxicity: Rat oral LD50 > 5000 mg/kg (low toxicity)
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms: Possible mild irritation to eyes and skin; inhalation of dust may cause coughing or sneezing
Chronic Effects: Not classified as carcinogen, mutagen, or reproductive toxin, based on available data
Target Organs: No data indicating target organ toxicity from regular laboratory use
Sensitization: Unlikely under normal usage, no cases reported
Aquatic Toxicity: No data available for fish or aquatic invertebrates at environmental concentrations
Bioaccumulation Potential: Low, compound is water-soluble and expected to have low potential for partitioning into biota
Environmental Fate: Material likely to dissociate in water to harmless products; not identified as persistent or bioaccumulative
Other Adverse Effects: No evidence of significant environmental harm expected under laboratory disposal practices
Waste Treatment Methods: Collect as non-hazardous chemical waste unless contaminated with hazardous substances
Disposal Guidance: Dispose of in accordance with local, regional, and national regulations for chemical laboratory waste
Container Disposal: Rinse empty containers before discarding in chemical waste stream; avoid discharging solutions directly to sewer without treatment or dilution
UN Number: Not regulated for transport
Transport Hazard Class: Not classified as dangerous goods for road (ADR/RID), air (IATA), or sea (IMDG) transport
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant
Transport Precautions: Package securely to prevent leaks or spills during shipping, keep separate from incompatible cargo
EU Regulation: Not classified as hazardous according to Regulation (EC) No. 1272/2008 (CLP)
TSCA Status (USA): Listed on Toxic Substances Control Act Inventory
REACH Status (EU): Exempt or registered in accordance with relevant regulations
Other National Inventories: Listed in Canada, Australia, Japan, Korea, China, and other chemical inventories
Label Requirements: Standard laboratory labeling with product name, supplier, and hazard information as appropriate
Restrictions: Not subject to any specific restrictions under chemical safety legislation for laboratory use
