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Product Name: TRIS 2 CARBOXIETIL FOSFINA CLORHIDRATO
Chemical Formula: C6H14ClO6P
Synonyms: Tris(carboxyethyl)phosphine hydrochloride
Recommended Use: Laboratory reagent, reducing agent in protein biochemistry
Supplier Information: Include contact information for domestic chemical supplier, manufacturer address, and emergency response phone number
CAS Number: 51805-45-9
Classification: Eye irritation Category 2A, Skin irritation Category 2, Specific Target Organ Toxicity — Single Exposure Category 3
Label Elements: Signal Word: Warning
Hazard Statements: Causes skin irritation, causes serious eye irritation, may cause respiratory irritation
Pictograms: Exclamation mark (GHS07)
Precautionary Statements: Avoid contact with eyes, skin, and clothing, avoid inhaling dust or mists, wash thoroughly after handling
Other Hazards: Powder may become airborne, irritate mucous membranes, decomposes under heat
Chemical Name: Tris(2-carboxyethyl)phosphine hydrochloride
Purity: 98% or greater
Impurities: Trace inorganic salts, water less than 3%
Molecular Weight: 286.60 g/mol
Ingredient Contribution: No components above 1% other than principal
CAS Registry Number: 51805-45-9
Inhalation: Move person to fresh air, seek medical attention if symptoms persist such as coughing or throat irritation
Skin Contact: Remove contaminated clothing, wash skin with soap and plenty of water, call a doctor in case of persistent redness or rash
Eye Contact: Rinse immediately with plenty of water for several minutes, lift eyelids occasionally, consult an ophthalmologist if discomfort continues
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical attention as precaution
Specific Symptoms: Burning sensation, redness, coughing, eye discomfort
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Specific Hazards: Decomposes under fire conditions, emits toxic fumes such as phosphorus oxides, carbon monoxide, hydrochloric acid vapors
Protective Equipment: Firefighters use self-contained breathing apparatus and full protective clothing
Advice for Firefighters: Move containers from hazard area if possible, prevent runoff from entering drains
Flash Point: Not applicable for non-volatile solids, but thermal decomposition releases hazardous fumes
Personal Precautions: Wear gloves, safety goggles, dust mask, and lab coat
Evacuation: Isolate spill area, prevent unauthorized access
Environmental Precautions: Prevent entry into sewers, waterways, and soil
Spill Cleanup Methods: Sweep up powder without creating dust, place in bag or closed container for disposal, ventilate area well, wash spill site with water after dry material is removed
Disposal of Contaminated Material: Follow local and national regulations regarding hazardous waste
Handling: Use in well-ventilated areas, avoid inhalation and contact with skin or eyes, do not eat, drink, or smoke during use
Storage Conditions: Store in tightly closed original container, in a cool, dry, and ventilated place, away from incompatible substances such as strong acids and oxidizing agents
Storage Temperature: Recommended at 2-8°C, protect from moisture and direct sunlight
Special Procedures: Keep separate from food and beverages, keep storage area clearly labeled and restricted to trained personnel
Engineering Controls: Use chemical fume hood, eye-wash station, and safety shower in work area
Respiratory Protection: Use NIOSH/MSHA-approved respirator if exposure or dust formation is possible
Eye Protection: Wear safety goggles (ANSI Z87.1)
Hand Protection: Nitrile or neoprene chemical-resistant gloves
Skin Protection: Wear lab coat, long sleeves, closed-toe shoes
Hygiene Measures: Wash hands and face after handling, remove contaminated clothing immediately, maintain clean work area
Occupational Exposure Limit: No established OSHA or ACGIH exposure limits for this compound, treat as hazardous chemical
Physical State: Solid
Appearance: White crystalline powder
Odor: Odorless
pH: 2.5–3.5 (1% solution in water)
Melting Point: Decomposes above 150°C
Boiling Point: Not applicable
Solubility: Soluble in water (up to 1 g/mL), slightly soluble in ethanol
Vapor Pressure: Not measurable (negligible at room temperature)
Relative Density: 1.8–2.0 (water=1)
Partition Coefficient (n-octanol/water): Not determined
Volatile Content: Non-volatile
Chemical Stability: Stable at room temperature if kept dry and protected from light
Reactivity: Reacts with strong oxidizers, strong acids, reducing agents
Conditions to Avoid: Moisture, excessive heat, direct sunlight
Hazardous Decomposition Products: Phosphorus oxides, carbon oxides, hydrogen chloride gas generated during combustion
Polymerization: No known hazardous polymerization
Acute Toxicity: Data lacking for oral LD50 in humans, expected to display moderate toxicity based on phosphorus compound analogs
Skin Corrosion/Irritation: Causes skin redness, itching, possible inflammation with prolonged contact
Eye Damage/Irritation: Causes severe irritation, conjunctivitis, watering, possible corneal injury
Inhalation Effects: Irritates respiratory tract, coughing, sneezing, shortness of breath possible
Chronic Effects: No data on carcinogenicity, mutagenicity, or reproductive toxicity in humans
Sensitization: Not reported but prudent to avoid repeated contact
Target Organ Effects: Eyes, skin, respiratory system
Ecotoxicity: Limited specific data available, likely hazardous to aquatic environments based on chemical class
Persistence and Degradability: Can degrade in water and soil, breakdown products include stable phosphates and carboxylic acids
Bioaccumulation Potential: Expected to have low bioaccumulation, hydrophilic nature
Mobility in Soil: Likely high due to water solubility, potential to leach into groundwater
Other Adverse Effects: Avoid release to the environment; local regulations may prohibit direct disposal
Waste Disposal Methods: Dispose as hazardous chemical waste through licensed contractor, do not flush to drains or landfill
Incineration: Suitable under controlled chemical incineration conditions meeting local emission standards
Contaminated Packaging: Rinse and dispose of as hazardous chemical packaging
Other Disposal Recommendations: Comply with national, regional, and local environmental control regulations, always check for regulatory reporting requirements
UN Number: Not classified as dangerous for transport according to most regulations
Proper Shipping Name: Not regulated
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Special Precautions for User: Protect from moisture, do not expose to temperature extremes, avoid spillage
Environmental Hazards: Avoid release to environment during transport
OSHA Status: Not specifically listed, standard chemical handling rules apply
TSCA Inventory: Listed
SARA Title III Sec. 313: No components subject to reporting
REACH / EU Regulations: Not classified as hazardous under CLP but full workplace precautions required
WHMIS (Canada): Not classified, but prudent workplace safeguards required
Other Local/National Regulations: Observe all applicable workplace safety, environmental monitoring, and transport safety rules regarding laboratory chemicals
