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Product Name: Tetrakis(triphenylphosphine)palladium(0)
Chemical Formula: Pd[P(C6H5)3]4
CAS Number: 14221-01-3
Synonyms: Tetrakis(triphenylphosphine)palladium, Pd(PPh3)4, Palladium(0), TPPP
Recommended Use: Catalyst for cross-coupling reactions in organic synthesis, chemical research in academic and industrial settings
Manufacturer/Supplier: Chemical supply companies and research distributors
Emergency Contact: Local poison control center, hospital emergency services, workplace health and safety officer
Classification: Skin irritant, Eye irritant, Respiratory irritant, Harmful if inhaled or ingested
Hazard Statements: May cause skin and eye irritation, respiratory tract irritation, toxic if swallowed or inhaled, potential reproductive toxin due to palladium compounds
Signal Word: Warning
Pictograms: Exclamation mark for irritation, health hazard symbol for long-term effects
Precautionary Statements: Avoid breathing dust or vapor, wear eye protection, wash hands thoroughly, use in well-ventilated areas, keep container tightly closed, avoid release into the environment
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Chemical Identity: Tetrakis(triphenylphosphine)palladium(0)
CAS Number: 14221-01-3
Content: ≥98% purity as supplied
Impurities: Small traces of phosphine oxides, palladium salts, residual organic solvents from manufacturing
Eye Contact: Rinse eyes cautiously with plenty of water for at least 15 minutes, remove contact lenses if safe to do so, seek medical advice
Skin Contact: Wash affected skin area with soap and water, remove contaminated clothing, consult physician for persistent irritation
Inhalation: Move to fresh air, monitor for respiratory distress, give oxygen if breathing becomes difficult, seek medical help promptly
Ingestion: Rinse mouth, drink water after exposure if not unconscious, do not induce vomiting, get medical attention as soon as possible
Most Important Symptoms: Irritation of eyes, nose, throat and skin, possible headache, nausea, allergic reactions in sensitive individuals
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, water spray (for small fires)
Unsuitable Media: Avoid direct water stream, which may spread the chemical
Specific Hazards: Incomplete combustion generates toxic fumes, phosphine, carbon monoxide, and palladium oxide dust
Protective Equipment: Full protective clothing, positive pressure self-contained breathing apparatus
Firefighting Procedures: Evacuate area, cool exposed containers with water spray from a safe distance, collect runoff water for proper disposal, use non-sparking tools to handle residue
Personal Precautions: Wear protective gloves and clothing, avoid dust formation, ventilate the area, isolate spill from unnecessary personnel
Environmental Precautions: Prevent further leakage or spillage if safe, avoid discharge into drains, waterways, or soil
Containment Procedures: Absorb spill with inert material (e.g. dry sand, vermiculite), collect into appropriate waste container, clean spill area with water and detergent
Disposal: Dispose of waste through licensed chemical waste disposal facility, comply with local environmental regulations
Precautions for Safe Handling: Work in fume hood or well-ventilated area, avoid contact with skin and eyes, prevent inhalation of dust or vapors, use non-reactive containers
Storage Conditions: Store in tightly sealed container in a cool, dry place away from direct sunlight, heat sources or incompatible substances, protect from moisture and air exposure, segregate from food and drink
Incompatibilities: Strong oxidizers, acids, chlorinated compounds, moisture-sensitive due to phosphine ligands
Hygiene Measures: Wash hands and equipment thoroughly after handling, do not reuse containers for food or beverage
Engineering Controls: Use local exhaust ventilation, chemical fume hood, closed system transfer if feasible
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), safety goggles or face shield, lab coat or coverall, closed-toe shoes
Respiratory Protection: NIOSH-approved respirator in case of insufficient ventilation, particularly during weighing, mixing, disposal
Exposure Limits: No OSHA PEL for compound itself, observe recommended limits for particulate matter, phosphine derivative exposure, and palladium compounds
Environmental Controls: Handle waste according to regional chemical regulations, prevent environmental release
Appearance: Yellow to bright gold crystalline solid or powder
Odor: Faint aromatic or phenyl-like odor
Melting Point: Decomposes around 120°C with loss of ligand
Boiling Point: Not applicable, decomposes before boiling
Solubility: Moderately soluble in toluene, benzene, chloroform, dichloromethane, insoluble in water
Vapor Pressure: Negligible under ambient conditions
Density: Approximately 1.3 g/cm3 at 20°C
pH: Not applicable (non-aqueous compound)
Other Properties: Air and moisture sensitive, can form dark decomposition products on exposure
Chemical Stability: Stable in original sealed packaging under recommended storage, decomposes in air, light or moisture
Hazardous Reactions: Forms toxic gases (CO, phosphine) on thermal decomposition, reacts exothermically with oxidizers
Conditions to Avoid: Exposure to light, heat, air or moisture, use with incompatible substances
Incompatible Materials: Oxidizing agents, acids, halogenated hydrocarbons, water vapor
Hazardous Decomposition Products: Phosphine, phenylphosphine oxide, palladium oxide, carbon monoxide, carbon dioxide
Acute Toxicity: Harmful if swallowed, inhaled or absorbed through the skin; oral LD50 (rat) >2000 mg/kg, limited data for the complex
Skin Corrosion/Irritation: Causes localized redness, irritation, in some cases sensitive individuals may develop contact dermatitis
Eye Damage/Irritation: Dust or particles cause eye discomfort, tearing, temporary vision blurring
Inhalation Toxicity: Palladium and phosphine ligand derivatives reported as respiratory irritants, chronic exposure may trigger allergic reactions
Sensitization: Possible allergic skin responses, no data on long-term carcinogenicity
Target Organs: Lungs, skin, eyes
Symptoms: Headache, nausea, stomach upset, irritation
Ecotoxicity: Toxic to aquatic life with long-lasting effects, palladium ions/breakdown products accumulate in sediment and impact invertebrates
Persistence and Degradability: Persistent in soil and water, breaks into palladium salts and triphenylphosphine oxide
Bioaccumulation: Palladium compounds accumulate in aquatic organisms
Mobility in Soil: Low mobility for parent complex, dissociates to mobile metal ions and organic fragments
Other Adverse Effects: Avoid uncontrolled release, utilize proper wastewater containment for laboratory and industrial uses
Waste Treatment Methods: Collect unused or waste material in clearly labeled, closed containers, avoid mixing with other chemical wastes
Disposal of Product: Send to licensed hazardous waste treatment facility, incinerate or landfill according to local law
Disposal of Containers: Triple-rinse empties before disposal, crush or puncture containers to prevent reuse, do not wash into drains
Special Precautions: Consult local, regional, and national regulations for palladium and organophosphine chemicals
UN Number: Not classified as hazardous for transport
Proper Shipping Name: Tetrakis(triphenylphosphine)palladium(0), chemical samples
Hazard Class: Not regulated for ground transport under DOT, IATA, IMDG
Packing Group: Not assigned
Environmental Hazards: Marine pollutant, avoid bulk shipment by water
Transport Precautions: Ship in tightly closed containers, protect from heat and moisture, avoid shipment with oxidizing substances
OSHA Status: Not listed as specifically regulated under OSHA; palladium metal and inorganic compounds regulated as nuisance dust
SARA Title III: Not listed in SARA 313, report spills over threshold planning quantity
TSCA: Listed on the TSCA Inventory as a research chemical
REACH Status (EU): Registered as substance of very low tonnage, subject to volume-based reporting
WHMIS Classification (Canada): D2B - Toxic Material Causing Other Toxic Effects
Other Regulatory Listings: Check state, provincial, or national lists for updated chemical handling and exposure limits
