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Name: Trifluoroacetic Anhydride
Chemical Formula: C4F6O3
Synonyms: TFAA
Appearance: Clear, colorless liquid with acrid odor
Common Uses: Reagent in organic synthesis, especially for acylation reactions
Hazard Class: Corrosive and flammable liquid
GHS Symbols: Corrosion, Flame, Exclamation mark
Primary Risks: Severe burns to skin and eyes, harmful if inhaled or ingested, flammable vapors, respiratory tract irritation
Chronic Exposure: Long-term contact can scar tissue, damage lung function, impact nervous system
Routes of Exposure: Skin, eye, inhalation, ingestion
Main Ingredient: Trifluoroacetic Anhydride
CAS Number: 407-25-0
Concentration: Typically over 98%
Other Possible Impurities: Trace moisture or acid contamination may occur depending on how material is stored
Inhalation: Remove to fresh air, keep airway clear, and call medical help if symptoms persist
Skin Contact: Remove contaminated clothing, wash with plenty of water, seek help for persistent irritation or burns
Eye Contact: Flush eyes with water for at least 15 minutes, hold eyelids apart, get immediate medical attention
Ingestion: Rinse mouth, never induce vomiting, seek urgent medical care
Symptoms to Watch: Burning, coughing, redness, difficulty breathing, swelling, chemical burns
Suitable Extinguishing Media: Dry chemical, CO2, alcohol-resistant foam
Special Hazards: Vapors can ignite easily; decomposition can give off toxic gases such as hydrogen fluoride, carbon monoxide, carbon dioxide
Protective Measures: Wear self-contained breathing apparatus and chemical-resistant suit, avoid inhaling fumes, keep upwind
Firefighting Approach: Cool containers with water from a safe distance to prevent rupture or explosion
Spill Response: Evacuate area, ventilate space, avoid breathing vapors, use non-sparking equipment
Cleanup Methods: Absorb liquid with inert material like dry sand, place residues in a chemical waste drum, never let it enter drains or sewers
Personal Protection: Nitrile gloves, splash goggles, impermeable clothing, respiratory protection if vapor concentration peaks
Environmental Impact: Prevent run-off; release can acidify water and threaten aquatic life
Safe Handling: Work in a chemical fume hood, keep away from heat, sparks, open flames, only open containers in controlled settings
Storage Conditions: Store in tightly sealed, resistant containers, separate from water, bases, alcohols, and oxidizing agents
Segregation: Keep away from moisture and sources of ignition, store with proper secondary containment
Practices: Use smallest possible quantities, label containers clearly, restrict access to trained staff
Engineering Controls: Strong local ventilation, full fume hood, explosion-proof electrical systems in storage areas
Personal Protective Equipment: Butyl or laminate gloves, goggles, face shield, acid-resistant apron, fitted respirator if airborne concentrations spike
Hygiene: Wash hands and arms thoroughly after handling, keep work clothes separate from street clothes
Exposure Limits: No published exposure limits; minimize exposure as much as possible
Appearance: Clear, colorless to pale yellow liquid
Odor: Acrid, sharp
Molecular Weight: 210.03 g/mol
Boiling Point: Around 39–41 °C
Melting Point: Below -40 °C
Vapor Pressure: High at room temperature
Solubility: Reacts with water
Density: Approximately 1.489 g/cm³ at 20 °C
Flash Point: Close to 6 °C (closed cup)
Chemical Stability: Stable under dry, cool, well-ventilated storage away from incompatible substances
Hazardous Reactions: Reacts violently with water, alcohols, bases; emits toxic fumes if broken down by heat or contact with moist air
Incompatible Materials: Bases, oxidizers, strong reducing agents, water, alcohols
Decomposition Products: Hydrogen fluoride, trifluoroacetic acid, carbon monoxide, carbon dioxide
Acute Toxicity: Causes severe burns; toxic effects on respiratory, digestive, and nervous systems; possible pulmonary edema after lung exposure
Skin and Eye Contact: Risk of blindness with eye exposure, deep ulceration, painful burns on skin
Inhalation: Severe irritation, choking, headache, dizziness, delayed lung damage
Chronic Exposure: Prolonged effects include inflammation, allergic skin response, chronic bronchitis
Sensitization: Not fully established
Carcinogenicity: Not classified as proven carcinogen but chronic irritation poses long-term health risks
Acute Risks: Toxic to aquatic life, persistent environmental threat, reacts in water to produce acid
Persistence and Degradation: Not readily biodegradable; breakdown products are mobile and highly persistent
Bioaccumulation: Low potential but spills can acidify water, harming plants and animals
Approach: Keep spills away from surface water and sewers, limit disposal to specialized chemical processes
Preferred Method: Dispose as hazardous waste through licensed chemical disposal contractor
Restrictions: Never pour down drain or throw in general garbage, never neutralize without technical oversight
Container Disposal: Rinse empty containers with caution, send for professional processing rather than landfill
Regulated Disposal: Full compliance with national and local laws on hazardous waste
Transport Classification: Classified as hazardous for ground, sea, and air
UN Number: Commonly shipped under UN 2699, Flammable liquid, corrosive, n.o.s.
Packing Group: II (substantial risk)
Label Requirements: Flammable, Corrosive
Precautions in Transit: Use leak-proof containers, temperature control, separation from incompatible goods, emergency procedures in case of spill or fire
Global Inventory: Listed in various chemical inventories such as TSCA (US), REACH (EU), DSL (Canada)
Workplace Regulations: Subject to strict workplace controls under chemical safety laws in many countries
Signal Words: Danger (severe risk)
Usage Restrictions: Restricted to use by trained chemical professionals only, not suitable for consumer or unsupervised academic use
Disclosure: Companies disclosing use to authorities as required under environmental and safety regulations
