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Product Name: Trifluoroacetic Acid
Chemical Formula: C2HF3O2
Synonyms: TFA, Trifluoroethanoic Acid
CAS Number: 76-05-1
Intended Use: Laboratory reagent, chemical synthesis, pharmaceutical industry
Manufacturer Information: Contact details for supplier, including address, phone, and emergency contact number
UN Number: 2699
GHS Classification: Acute Toxicity (Oral, Dermal, Inhalation): Category 3; Skin Corrosion: Category 1A; Eye Damage: Category 1; Specific Target Organ Toxicity (Single Exposure): Category 3
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage; May cause respiratory irritation; Toxic if swallowed, in contact with skin, or inhaled
Pictograms: Corrosive, Skull and Crossbones, Exclamation Mark
Precautionary Statements: Do not breathe dust or mist; Wear protective gloves, protective clothing, eye protection, and face protection; Immediately call a poison center or doctor
Chemical Name: Trifluoroacetic Acid
Concentration: ≥99%
Impurities: Water, trace organics, less than 1%
Molecular Weight: 114.02 g/mol
Inhalation: Move person to fresh air and keep comfortable; Seek immediate medical help if breathing is difficult; Use artificial respiration if breathing has stopped
Skin Contact: Remove contaminated clothing and rinse skin with plenty of water for at least 15 minutes; Seek medical attention for burns or continued irritation
Eye Contact: Rinse cautiously with water for several minutes; Remove contact lenses if present and easy to do; Continue rinsing and get urgent medical aid
Ingestion: Rinse mouth; Do not induce vomiting; Give water to drink, only if person is conscious; Immediate medical care required
Most Important Symptoms: Burning pain, severe irritation, chemical burns to skin and eyes, breathing difficulties
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Unsuitable Media: Direct water stream may cause chemical splatter
Hazardous Combustion Products: Carbon oxides, hydrogen fluoride, trifluoroacetyl fluoride
Protective Equipment: Firefighters wear full protective gear, including self-contained breathing apparatus
Special Precautions: Approach from upwind; Avoid inhaling vapors; Prevent runoff into drains or waterways
Personal Precautions: Evacuate area; Wear chemical-resistant gloves, safety goggles, and appropriate protective clothing; Use respiratory protection if ventilation inadequate
Environmental Precautions: Prevent further leakage or spillage; Do not let chemical enter sewers, surface, or ground water
Methods for Containment and Cleaning: Stop leak if safe; Absorb with non-combustible material like sand or earth; Place into suitable container for disposal; Ventilate area and wash spill site after collection
Safe Handling: Work in fume hood or well-ventilated area; Avoid contact with skin, eyes, and clothing; Handle with acid-resistant gloves and face protection; Use tools and containers designed for chemical resistance
Storage Conditions: Store in tightly closed container in a cool, dry, and well-ventilated place; Keep locked up and out of reach of children; Keep away from incompatible materials, such as bases and oxidizing agents
Incompatible Substances: Strong bases, oxidizers, reactive metals
Occupational Exposure Limits: ACGIH TLV: 2.5 mg/m³ (Ceiling)
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to control airborne levels
Personal Protective Equipment: Chemical-resistant gloves, long-sleeved lab coat or apron, splash-proof goggles, face shield
Respiratory Protection: Approved respirator if ventilation inadequate
Hygiene Measures: Wash hands thoroughly after handling; Remove contaminated clothing before entering common areas
Appearance: Colorless, fuming liquid
Odor: Sharp, vinegar-like
pH: Strongly acidic (approximately pH 0.3 for 1 M solution)
Melting Point: -15.4 °C
Boiling Point: 72.4 °C
Flash Point: 41 °C (Closed cup)
Evaporation Rate: Data not available
Flammability: Not highly flammable but vapor may form explosive mixture with air
Vapor Pressure: 57 hPa at 20 °C
Density: 1.489 g/cm³ at 20 °C
Solubility: Miscible with water, alcohols, ethers
Vapor Density: 3.97 (air = 1)
Chemical Stability: Stable under recommended conditions
Hazardous Reactions: May react violently with strong bases and oxidizers; Reacts with metals, liberating hydrogen gas
Conditions to Avoid: Heat, flames, ignition sources, moisture
Hazardous Decomposition Products: Hydrogen fluoride, carbon monoxide, carbon dioxide, trifluoroacetyl fluoride
Acute Toxicity: LD50 Oral (rat): 200 mg/kg; LD50 Dermal (rabbit): 580 mg/kg
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Symptoms of Exposure: Corrosive burns on contact, tearing, pain, breathing difficulty, abdominal pain, headache
Chronic Effects: Damage to liver or kidneys possible from repeated exposure; May aggravate underlying respiratory conditions
Carcinogenic Status: Not classified as a known carcinogen by IARC, NTP, OSHA
Toxicity to Aquatic Life: Harmful to aquatic organisms; May cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Expected to persist in the environment; Limited biodegradability
Bioaccumulative Potential: Low potential for bioaccumulation
Mobility in Soil: High; readily migrates in soil and groundwater
Other Ecological Effects: May acidify water and soil, causing ecological harm
Disposal Methods: Dispose of as hazardous waste in accordance with federal, state, and local regulations; Use licensed chemical waste disposal contractor
Container Disposal: Rinse empty container thoroughly with suitable neutralizing agent and dispose of container as hazardous waste
Precautions: Do not release into drains, watercourses, or soil; Involve EPA-licensed disposal companies for large quantities
UN Number: 2699
Proper Shipping Name: Trifluoroacetic Acid
Transport Hazard Class: 8 (Corrosive materials)
Packing Group: II
Labels: Corrosive
Special Precautions for Transport: Store upright in approved containers; Secure against movement; Do not transport with incompatible chemicals such as bases, cyanides, or oxidizers
US Federal Regulations: Listed in TSCA Inventory; Subject to SARA Title III Sections 302 and 313; OSHA hazardous chemical
European Union: Classified as a dangerous substance under CLP; REACH registered
Canada: Listed in DSL; Classified as WHMIS Class E (Corrosive Material)
Other Regulatory Lists: Included in major national chemical inventories; Local and national regulations may apply regarding handling, storage, and disposal
