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Name: Tranylcypromine Sulfate
Chemical Formula: C9H11N•H2SO4
Common Use: Used as an antidepressant, primarily in hospitals or pharmacies where MAO inhibitors are needed for treatment-resistant depression
Synonyms: 2-phenylcyclopropylamine hemisulfate
Appearance: White to off-white crystalline powder
Route of Exposure: Inhalation, ingestion, skin and eye contact are possible in occupational settings
Hazard Classification: Toxic to nervous system and can cause severe health effects after ingestion
Signal Word: Danger
Acute Effects: Headache, agitation, confusion, elevated blood pressure, risk of hypertensive crisis
Chronic Effects: Repeated exposure can potentially cause lasting changes to central nervous system functioning
Target Organs: Brain, cardiovascular system, liver
Environmental Hazards: Harmful to aquatic life; spills should not enter water systems
Main Ingredient: Tranylcypromine hemisulfate salt
CAS Number: 13492-01-8
Concentration: Pure pharmaceutical forms contain 100% active compound with trace excipients in formulated drug products
Impurities: Pharmaceutical grade, usually low-level manufacturing byproducts
Inhalation: Remove the person to fresh air and support breathing with medical attention if symptoms develop
Skin Contact: Wash thoroughly with soap and running water; remove contaminated clothing
Eye Contact: Rinse eyes gently with water for several minutes; seek medical help if discomfort persists
Ingestion: Seek medical attention immediately, do not induce vomiting unless instructed by poison control
Symptoms Needing Attention: High blood pressure, confusion, muscle twitching, severe headache
Flammability: Not considered highly flammable in bulk solid form
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Special Hazards: Burning can produce toxic nitrogen and sulfur oxides
Protective Equipment: Firefighters use self-contained breathing apparatus and full protective gear due to toxic fumes
Fire Response: Avoid inhalation of combustion byproducts, ventilate area after fire
Personal Precautions: Wear gloves, lab coat, safety glasses; avoid inhaling dust
Environmental Precautions: Prevent spillage from entering drains or waterways
Cleanup Methods: Scoop up solid material into a labelled container; use damp cloth for fine residues; ventilate area
Waste Disposal: Place collected material in a closed, properly labelled chemical waste container
Handling: Use in laboratories with chemical fume hoods or local ventilation; avoid direct contact with skin
Hygiene Measures: Wash hands after handling; no eating, drinking, or smoking in work areas
Storage: Store tightly closed in a dry, cool place, protected from direct sunlight and incompatible chemicals like strong acids or oxidizers
Segregation: Keep away from food items and personal care products
Engineering Controls: Laboratories use chemical fume hoods or local exhaust systems for airborne particles
Personal Protection: Gloves (nitrile or latex), lab coat, safety glasses; respirators when dust clouds may form
Work Practices: Follow standard precautions for handling drug substances; minimize dust generation and accumulation
Occupational Exposure Limit: No established occupational exposure limit; minimize exposure as a prudent practice
Appearance: Fine white or off-white crystalline powder
Odor: No distinct odor
Solubility: Soluble in water
Melting Point: Range depends on hydrate state, but falls around 165–173°C for the salt
pH (1% Solution): Slightly acidic
Stability: Stable under recommended storage conditions, but sensitive to moisture in the air
Chemical Stability: Stable at room temperature, away from moisture and incompatible materials
Reactivity: Avoid contact with strong oxidizing agents, strong acids, strong bases
Decomposition Products: Combustion may yield nitrogen oxides, sulfur oxides, carbon monoxide, carbon dioxide
Hazardous Polymerization: Not known to occur under normal usage
Acute Toxicity: Oral ingestion can cause severe central nervous system effects, cardiovascular stress, risk of death at high doses
Signs and Symptoms: Hypertensive crisis, agitation, muscle spasms, potential seizures
Routes of Exposure: Inhalation (if powdered), ingestion, skin and eye contact
Long-Term Effects: Neurological changes, possible liver effects with repeated exposure
Sensitization: Not typically a skin sensitizer, but caution recommended as with all psychoactive chemicals
Carcinogenicity: No evidence found linking Tranylcypromine to cancer in humans
Ecotoxicity: Known to be toxic to aquatic invertebrates at high concentrations; causes concern if large spills enter waterways
Persistence and Degradability: Limited data suggests slow breakdown in aquatic environments
Bioaccumulation: Not expected to bioaccumulate significantly
Precautions: Spilled product should be contained and properly disposed of to minimize environmental impact
Waste Handling: Dispose as hazardous pharmaceutical waste; follow local, regional, and national guidelines
Incineration: High temperature incineration recommended for complete destruction
Contaminated Packaging: Rinse thoroughly or manage as chemical waste, depending on local rules
Water Release: Never discharge untreated material to sewers or waterways to avoid ecological disruption
Regulatory Status: Not classified as dangerous for transport under most international transport rules
Packaging Requirements: Secure, leak-proof, labelled containers
Special Precautions: Protect from moisture and incompatible materials during transport
Controlled Substance: Scheduled for prescription-only use in many countries due to pharmacological effects
Workplace Safety: Subject to occupational health and safety standards for laboratory and medical personnel
Environmental Rules: Releases into the environment regulated under pharmaceutical waste laws in many jurisdictions
