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Product name: TiterMax Gold Adjuvant
Synonyms: Immunological adjuvant, TiterMax Gold
Manufacturer: Norbrook Laboratories Ltd.
Supplier contact: Emergency Telephone: +1-800-424-9300
Product use: Animal research reagent; Immunization adjuvant
Product code: G1000
Address: 10 Brunel Way, Thetford, Norfolk, IP24 1HP, United Kingdom
Classification: Irritant to skin, eyes, and respiratory tract according to OSHA GHS criteria
Primary hazards: Prolonged or repeated skin contact may provoke allergic reactions; Dust or aerosol inhalation may cause respiratory discomfort; Eye contact may lead to local inflammation
Signal word: Warning
Hazard statements: Causes skin and serious eye irritation; May cause allergy or asthma symptoms or breathing difficulties if inhaled
Pictograms: Exclamation Mark, Health Hazard
Precautionary statements: Wash exposed skin thoroughly after handling; wear protective gear; avoid breathing dust, fume, or mist; call doctor if symptoms occur
Main components: Squalene (CAS 111-02-4, 70-75%), Block copolymer (Proprietary, 10-20%), Mannide monooleate (CAS 959-06-0, 1-5%), Phosphate buffered saline (mixture, 5-10%)
Impurities: Contains residual solvents below hazard thresholds; no known carcinogens; non-toxic stabilizers included
Chemical family: Emulsion of oils and surfactants with buffer
Inhalation: Move person to fresh air; seek medical attention for symptoms such as shortness of breath or wheezing
Skin contact: Remove contaminated clothing; wash skin thoroughly with soap and water; seek advice if irritation develops
Eye contact: Flush eyes with water for several minutes; remove contact lenses if present; continue rinsing until discomfort eases or 15+ minutes, get medical help for persistent symptoms
Ingestion: Rinse mouth with water, do not induce vomiting; seek prompt medical attention if feeling unwell
Most important symptoms: Redness, itching, swelling, respiratory difficulty
Suitable extinguishing media: Water fog, carbon dioxide (CO₂), foam, dry chemical
Unsuitable extinguishing media: Do not use high-pressure water jets directly on burning product
Specific hazards: Emits toxic fumes of carbon oxides under fire conditions
Protective equipment: Firefighters should wear full protective clothing including self-contained breathing apparatus; avoid contact with skin and eyes during response
Advice for firefighters: Prevent runoff from entering water systems; cool containers exposed to flame with water spray
Personal precautions: Wear impervious gloves, safety goggles, lab coat; ventilate area; avoid creating aerosol
Environmental precautions: Prevent spills from reaching waterways, drains, soil
Cleanup methods: Absorb with inert material such as sand or earth; transfer to suitable disposal containers; wash spill site after pickup; dispose as hazardous waste
Safe handling: Use in well-ventilated settings; avoid inhalation and contact with skin, eyes, clothing; no eating or drinking where product handled
Storage requirements: Store tightly sealed in original container at 2-8°C away from light, ignition sources, strong oxidizers
Incompatibles: Avoid storing with acids, alkali, oxidizing agents
Hygiene standards: Wash hands after handling; remove contaminated clothing and wash before reuse
Permissible exposure limits: No OSHA or ACGIH exposure limits assigned for main components
Engineering controls: Use local exhaust ventilation or fume hood
Personal protective equipment (PPE): Nitrile or neoprene gloves, safety goggles, splash-proof lab coat, NIOSH-approved respirator in insufficient ventilation
Environmental controls: Have eyewash station and safety shower nearby; prevent spillage outside work area
Appearance: Milky white to off-white viscous emulsion
Odor: Light, characteristic
Odor threshold: Not established
pH: 6.5-7.5
Melting point/freezing point: Approximately 0°C due to aqueous phase
Boiling point: No data (above 100°C, aqueous phase evaporates)
Flash point: >100°C
Evaporation rate: Not volatile under storage conditions
Flammability: Not classified as flammable
Vapor pressure: Negligible
Vapor density: Not applicable
Solubility: Easily dispersible in water
Partition coefficient (n-octanol/water): Not determined
Auto-ignition temperature: Not evaluated
Decomposition temperature: Not established
Viscosity: High viscosity
Chemical stability: Stable in recommended storage and use conditions
Reactivity: Unreactive in normal lab processes
Hazardous reactions: None under normal use
Conditions to avoid: High temperatures, open flames, incompatible materials
Incompatible materials: Strong acids, alkalis, oxidizers
Decomposition products: Carbon oxides, irritant fumes if burned or exposed to heat
Acute toxicity: Low toxicity expected from small, single exposures; calculated LD50 for formulation >2,000 mg/kg (rat, oral); Mannide monooleate and squalene identified as irritants in literature
Skin corrosion/irritation: May cause redness, dryness, blistering with repeated or prolonged exposure
Eye damage/irritation: Likely to cause pain, redness
Respiratory sensitivity: Prolonged inhalation may exacerbate asthma or other respiratory conditions
Skin sensitivity: Some risk of allergy with frequent skin contact
Chronic effects: No evidence for carcinogenicity, mutagenicity from components based on available animal studies
Medical conditions aggravated: Asthma, eczema, pre-existing skin or respiratory diseases
Ecotoxicity: Emulsion disrupts aquatic microorganism balance; components harmful at high concentration to aquatic life
Persistence and degradability: Biodegradable; squalene and monooleate degrade in soil and water
Bioaccumulation potential: Low; ingredients metabolized by environmental microorganisms
Mobility in soil: Medium; may migrate if entering surface water
Other adverse effects: No known ozone depletion, not classified as marine pollutant by UN; avoid release to environment
Waste treatment methods: Dispose of unused adjuvant, contaminated PPE, clean-up materials at licensed hazardous waste facility
Container disposal: Triple-rinse then puncture empty containers before disposal; follow local, state, and federal regulations
Environmental considerations: Do not pour into sewage or public water supplies; avoid landfills for bulk wastes
UN Number: Not regulated for transport under UN, ADR, IMDG, IATA rules
Proper shipping name: Not dangerous goods; ship in original packaging or sealed secondary containment
Hazard class: Non-hazardous
Packing group: Not assigned
Special precautions: Avoid extreme temperatures and excessive vibration; keep upright during transit; ship via reputable carrier
US EPA status: Not listed as hazardous substance or priority pollutant
OSHA: Not specifically regulated; treat as potential irritant, use PPE
SARA section 313: No components subject to reporting
TSCA: All components listed or exempt
California Prop 65: None of the components listed as causing cancer, birth defects
EU Regulation: Not classified as hazardous under Regulation (EC) No 1272/2008; Observe standard chemical lab safety
REACH Registration: Components exempt as research chemicals
Other regulations: Recommended to follow best practices in chemical hygiene and environmental safety
