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Chemical Name: Titanium (IV) Isopropoxide
Synonyms: Titanium Tetraisopropoxide, TTIP
CAS Number: 546-68-9
Molecular Formula: C12H28O4Ti
Recommended Use: Metal oxide precursor, catalyst, coatings, ceramics
Supplier Information: Emergency telephone and contact information appear on manufacturer or distributor’s label.
Classification: Flammable liquid (Category 2), Skin irritation (Category 2), Eye irritation (Category 2A), Specific target organ toxicity-single exposure (Category 3)
Signal Word: Danger
Hazard Pictograms: Flame, Exclamation mark
Hazard Statements: Highly flammable liquid and vapor. Causes skin and eye irritation. May cause respiratory irritation.
Precautionary Statements: Keep away from heat, sparks, and open flames. Avoid breathing vapors. Wear protective gloves, eye protection, and face shields. Use only outdoors or in well-ventilated areas.
Chemical Identity: Titanium (IV) Isopropoxide
Concentration: ≥98% by weight
Impurities: Only trace quantities of isopropanol and related alkoxides; components present below reporting threshold
EC Number: 208-909-7
Inhalation: Move affected individual to fresh air, keep at rest in a comfortable position. Seek medical help if breathing discomfort persists.
Skin Contact: Immediately flush exposed skin with copious amounts of water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention promptly if irritation develops.
Eye Contact: Quickly rinse open eyes with running water for several minutes, holding eyelids apart. Seek immediate medical assistance.
Ingestion: Do not induce vomiting. Rinse mouth with water if person is conscious. Request immediate medical evaluation.
Suitable Extinguishing Media: Dry chemical, CO2, alcohol-resistant foam. Avoid using water directly on flames or liquid.
Specific Hazards: Combustion generates irritating and toxic fumes such as metal oxides, hydrocarbons; vapors may form explosive mixtures with air.
Protective Equipment: Firefighters should wear full protective gear and self-contained breathing apparatus. Remain upwind and evacuate area if necessary.
Special Procedures: Cool containers with water spray to prevent rupture. Prevent runoff from entering waterways.
Personal Precautions: Evacuate unnecessary personnel. Avoid inhaling vapors, contact with skin and eyes. Wear chemical-resistant gloves, goggles, lab coat, and use positive pressure respiratory protection if ventilation inadequate.
Environmental Precautions: Keep spilled substance away from drains, surface water, or soil. Notify local authorities if significant environmental release occurs.
Spill Response: Absorb with non-combustible material like sand, earth, or vermiculite. Use spark-proof tools. Dispose of collected material according to regulations. Ventilate area.
Handling: Work in a chemical fume hood. Wear appropriate PPE and avoid direct physical contact. Prevent static discharge by grounding containers.
Storage: Store tightly closed in original container in a cool, dry, well-ventilated area. Keep away from sources of ignition, moisture, acids, alcohols, and incompatible substances. Segregate from oxidizing agents.
Special Requirements: Ground and bond containers when transferring flammable liquids. Do not store in glass containers for extended periods due to possible hydrolysis.
Exposure Limits: No OSHA, ACGIH, or NIOSH exposure limits established for Titanium (IV) Isopropoxide. Employers should monitor for isopropanol limits if decomposition possible.
Engineering Controls: Local exhaust or general ventilation to control exposure to airborne vapors.
Personal Protective Equipment: Chemical-resistant gloves (nitrile, neoprene), splash-proof safety goggles, lab coat/coveralls, approved respirators where vapor concentrations likely to exceed occupational exposure limits.
Hygiene Measures: Remove contaminated clothing and wash after handling. Do not eat, drink, or smoke in work areas. Wash hands thoroughly before breaks.
Appearance: Colorless to pale yellow liquid
Odor: Pungent, alcoholic
Odor Threshold: Not available
pH: Not applicable
Melting Point/Freezing Point: -15°C to -10°C
Boiling Point: 232°C at 101.3 kPa
Flash Point: 23–27°C
Evaporation Rate: Not determined
Flammability: Highly flammable
Upper/Lower Flammable Limits: Not available
Vapor Pressure: 0.47 mmHg at 25°C
Vapor Density: 7.6 (air=1)
Relative Density: 0.96–0.98 g/cm³
Solubility: Reacts with water to form insoluble titanium dioxide and isopropanol
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: 210°C
Decomposition Temperature: Not determined
Viscosity: 3.3 mPa·s at 25°C
Chemical Stability: Stable under recommended storage conditions. Rapidly hydrolyzes in presence of moisture, forming isopropanol and titanium dioxide.
Reactivity: Reacts strongly with water, alcohols, and acids.
Incompatible Materials: Moisture, strong oxidizing and reducing agents, acids, bases
Hazardous Decomposition: Thermal decomposition releases flammable and toxic fumes, including titanium oxides and organic fragments.
Polymerization: No hazardous polymerization expected under normal handling.
Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Acute Toxicity: LD50 (oral, rat): 3120 mg/kg; data indicate irritation but not high acute toxicity by ingestion.
Skin Corrosion/Irritation: Causes moderate to severe irritation on contact.
Serious Eye Damage/Irritation: Severe eye irritant, risk of potential eye injury with direct exposure.
Respiratory: May cause cough, sore throat, shortness of breath due to respiratory tract irritation.
Chronic Effects: Prolonged or repeated exposure can cause dermatitis. No evidence of carcinogenicity or mutagenicity available. Effects likely due to hydrolysis products.
Aquatic Toxicity: No measured data for aquatic organisms; hydrolysis produces titanium dioxide (low solubility, low toxicity) and isopropanol (may impact aquatic life at high concentrations).
Persistence and Degradability: Rapid hydrolysis in water; products expected to be environmentally persistent but inert.
Bioaccumulative Potential: Bioaccumulation unlikely for titanium dioxide; isopropanol not considered bioaccumulative.
Mobility in Soil: Limited mobility expected due to hydrolytic conversion to insoluble titanium dioxide.
Other Adverse Effects: Prevent release to waterways due to the formation of fine particulates.
Waste Treatment Methods: Incineration: Use licensed waste disposal contractors with suitable facilities. Do not pour into drains.
Container Disposal: Rinse containers with compatible solvent, then destroy by controlled means in accordance with local regulations.
Precautions: Treat as hazardous waste. Avoid disposal that would contaminate water, food, or feed.
Regulatory Waste Codes: Consult local, state, or national regulations for applicable disposal codes and procedures.
UN Number: UN2924
Proper Shipping Name: Flammable liquid, corrosive, n.o.s. (Titanium tetra(isopropoxide))
Transport Hazard Class: 3 (Flammable Liquids), 8 (Corrosive Substances)
Packing Group: II
Label: Flammable liquid, corrosive
Special Transport Precautions: Ensure containers are sealed and in upright position. Notify carrier of nature and hazard classification. Limit transport with incompatible substances.
US TSCA: Listed
EU REACH: Registered substance
OSHA, CERCLA, EPCRA: Not listed as an extremely hazardous substance.
SARA Title III: Not subject to reporting requirements under Sections 302, 304, or 313.
WHMIS (Canada): B2 (Flammable Liquid), D2B (Toxic Material Causing Other Effects)
California Proposition 65: Not listed as carcinogenic
Other Labels: Follow all national and regional regulatory guidance for storage, use, and transport.
