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Product Name: Thrombin from Bovine Plasma
Chemical Name: Thrombin, Bovine
Synonyms: Bovine Thrombin, Coagulation Factor IIa
Product Code: Relevant supplier code as provided
Manufacturer: Details from the provider or supplier
Recommended Use: Laboratory research, diagnostic, pharmaceutical preparation
Emergency Contact: Emergency telephone number of supplier or local poison control center
Address: Physical address of manufacturer or distributor for traceability
Email: Customer support or safety contact email of provider
Classification: Not classified as hazardous under GHS standards for laboratory quantities (consult large-scale use guidance)
Acute Health Hazards: Possible allergen if inhaled or in contact with skin and eyes; risk of irritation, sensitization
Chronic Health Hazards: Potential for long-term sensitization with repeated exposure; rare risk of anaphylaxis
Physical Hazards: No significant physical hazard; forms powder or lyophilized solid
Environmental Hazards: Low expected environmental toxicity but use caution near waterways
Warning Pictograms: Exclamation mark if classified as irritant
Signal Word: Caution or Warning as indicated by exposure risk
Main Ingredient: Thrombin from bovine plasma
Chemical Formula: C54H85N17O14S
Concentration: Typically supplied as purified protein, 100% active ingredient
CAS Number: 9002-04-4
Additives: Possible stabilizers (e.g., mannitol, sodium chloride), information varies by supplier
Impurities: Trace bovine plasma proteins, buffer components in formulation
Protein Source: Bovine plasma, USDA-inspected origin common
Inhalation: Move person to fresh air; monitor for allergic reactions or breathing difficulty; seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash affected area with plenty of soap and water; treat irritation or rash with suitable medication if necessary
Eye Contact: Rinse eyes cautiously with water for several minutes; remove contact lenses if easy; obtain medical assessment for persistent redness or pain
Ingestion: Rinse mouth with water; observe for symptoms like nausea, consult a physician
Note to Physicians: Treat symptomatically; hypersensitivity must be monitored
Suitable Extinguishing Media: Dry chemical, CO2, water fog, or foam
Unsuitable Media: Do not use water jet; may spread material
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, oxides of nitrogen and sulfur
Protective Equipment: Self-contained breathing apparatus, protective clothing
Fire/Explosion Risk: Non-flammable solid; dust formation possible in handling, avoid ignition sources
Personal Precautions: Wear gloves, laboratory coat, dust mask, and eye protection; avoid generating dust
Environmental Precautions: Keep out of drains and water sources
Cleanup Methods: Gently sweep or vacuum up material, transfer to sealed container; wash area with soapy water; ventilate enclosed spaces
Handling: Operate in a well-ventilated area, minimize inhalation or contact, do not eat or drink, maintain hygiene
Storage: Store at 2–8°C; avoid moisture and direct sunlight; keep container tightly closed; segregate from incompatible materials
Incompatibles: Strong oxidizers, acids, extreme heat
Exposure Limits: No occupational exposure limits established; monitor as appropriate for protein dusts
Engineering Controls: Use biosafety cabinet or local exhaust ventilation
PPE: Nitrile or latex gloves, laboratory coat, safety goggles; N95 mask or equivalent if risk of dust
Hygiene Measures: Always wash hands after handling and before meals; do not touch face or exposed skin
Appearance: White to off-white powder or lyophilized cake
Odor: Practically odorless
Solubility: Soluble in water or physiological saline
pH: Usually pH 6–8 in solution
Melting/Boiling Point: Not applicable for protein solids
Flash Point: Not available
Density: Not available, typically low due to protein structure
Auto-Ignition Temperature: Not available
Molecular Weight: Approximately 36,700 Daltons
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: No dangerous reactivity expected
Decomposition: Thermal decomposition on strong heating forms toxic gases
Polymerization: Will not occur
Incompatible Materials: Strong acids, oxidizers
Routes of Exposure: Inhalation, skin, eye, ingestion
Acute Toxicity: Low toxicity; allergenic reaction possible
Chronic Effects: Potential for sensitization and allergic response
Carcinogenicity: Not listed as carcinogen
Mutagenicity: No data suggesting mutagenicity
Reproductive Toxicity: No evidence of reproductive hazard in supplied form
Aquatic Toxicity: Not expected to pose significant hazard to aquatic life at laboratory scale
Degradability: Biodegradable protein
Bioaccumulation: Not expected
Mobility: Disperses readily in water
Waste Disposal: Treat as biohazardous laboratory waste; autoclave prior to disposal if required
Container Disposal: Empty containers must be rinsed and disposed according to local, state, and federal regulations
Environmental Precautions: Avoid release to the environment or water systems
Recommended Handling: Transfer to licensed waste disposal contractor after decontamination
UN Number: Not assigned
Proper Shipping Name: Not regulated as hazardous for transport in laboratory quantities
Transport Hazard Class: Non-dangerous goods
Packing Group: Not applicable
Special Precautions: Maintain cool chain if shipping, pack to avoid breakage
OSHA: Not listed as hazardous chemical under OSHA standards for laboratory use
TSCA: Exempt as naturally occurring biological substance
EU Regulation: Not classified under CLP
WHMIS Classification: Not controlled (Canada)
SARA Title III: Not subject to reporting
Other Regulations: Consult national, state, or local provisions for workplace biological safety and allergen handling
Labeling Requirements: Laboratory use, biohazard if not GMP certified
