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Material Safety Data Sheet for Thioacetamide

Identification

Product Name: Thioacetamide
Chemical Formula: C2H5NS
CAS Number: 62-55-5
Synonyms: Acetamidothiol, Ethanethioamide
Recommended Use: Laboratory reagent, chemical synthesis
Supplier: Major chemical suppliers and laboratory distributors
Contact Information: Emergency contact available on distributor’s label, typically includes phone and address for chemical emergencies or health inquiries

Hazard Identification

Classification: Acute toxicity, Carcinogenicity, Skin and eye irritation
Signal Word: Danger
Hazard Statements: Toxic if swallowed, suspected of causing cancer, causes skin and eye irritation, may damage organs
Precautionary Statements: Avoid inhalation, prevent contact with skin and eyes, wash thoroughly after handling, wear protective gear, do not eat or drink around the substance, handle in a well-ventilated area
Symbols: Skull and crossbones, health hazard, exclamation mark

Composition / Information on Ingredients

Chemical: Thioacetamide
Concentration: Over 99% in most lab-grade materials
Impurities: Trace impurities possible, amounts and types available from supplier upon request
CAS Number: 62-55-5
EC Number: 200-541-4

First Aid Measures

General Measures: Take victim to fresh air, keep warm and at rest, seek medical advice immediately
If Inhaled: Move exposed person out of exposure area, give artificial respiration if breathing stops, seek emergency help
Contact with Skin: Rinse skin with water for 15 minutes, remove contaminated clothing, wash skin with soap, seek medical attention for irritation or burns
Contact with Eyes: Rinse eyes cautiously with water for at least 15 minutes, remove contact lenses, consult a doctor
If Swallowed: Rinse mouth, never induce vomiting, seek medical help immediately, keep victim under observation

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Specific Hazards: Releases toxic fumes of sulfur oxides and nitrogen oxides upon combustion, may create hazardous decomposition products
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective gear
Firefighting Instructions: Use water to cool containers, avoid inhalation of smoke, evacuate area if necessary, fight fire from safe distance

Accidental Release Measures

Personal Precautions: Evacuate area, avoid breathing dust, wear gloves, safety goggles, face shield, and suitable respirator
Environmental Precautions: Prevent release into soil, drains, or water courses
Cleanup Methods: Scoop up material with spark-proof tools, place in tightly closed containers for disposal, clean contaminated area with water and detergent, ventilate area, follow disposal guidelines for hazardous waste

Handling and Storage

Handling: Use with adequate ventilation, minimize dust generation, avoid contact with eyes and skin, wash hands after handling, keep away from open flames and sources of high heat, use tools and containers compatible with the material
Storage: Store in a cool, dry, well-ventilated area away from incompatible materials, keep containers tightly closed and properly labeled, limit access to trained personnel, store in original containers or chemical-safe alternatives

Exposure Controls and Personal Protection

Engineering Controls: Use chemical fume hood, local exhaust ventilation, keep concentrations below occupational exposure limits set by OSHA, ACGIH, or local authorities
Personal Protection: Chemical-resistant gloves, lab coat, chemical splash goggles, dust mask or respirator, closed shoes, face shield as needed, no eating or drinking in work areas
Monitoring: Routine air monitoring may be required, inspect PPE before use, replace damaged items immediately

Physical and Chemical Properties

Appearance: White to gray crystalline powder
Odor: Characteristic sulfur odor, slightly unpleasant
Melting Point: 110-114°C
Boiling Point: Decomposes before boiling
Density: 1.34 g/cm³ at 20°C
Solubility: Soluble in water, ethanol, and acetone
Vapor Pressure: Not significant at room temperature
pH: Not applicable
Flash Point: Not flammable in solid state; dust may be combustible
Decomposition: Decomposes at high temperature to emit sulfur and nitrogen oxides

Stability and Reactivity

Chemical Stability: Stable under normal temperatures and pressures
Conditions to Avoid: Heat, flames, sources of ignition, moisture, incompatible substances
Incompatible Materials: Strong oxidizers, acids, bases, nitrates
Hazardous Decomposition Products: Hydrogen sulfide, carbon oxides, nitrogen oxides, sulfur oxides
Polymerization: Does not polymerize under recommended storage conditions

Toxicological Information

Acute Toxicity: Oral LD50 (rat) approximately 240 mg/kg, inhalation LC50 data not fully defined
Routes of Exposure: Ingestion, inhalation, skin and eye contact
Symptoms: Nausea, headache, dizziness, vomiting, skin rash, eye redness, potential organ damage after exposure
Chronic Effects: Classified as possibly carcinogenic to humans (IARC Group 2B), chronic exposure may lead to liver and kidney toxicity
Sensitization: No significant sensitization reports
Mutagenicity: Reports suggest genetic toxicity in lab studies

Ecological Information

Aquatic Toxicity: Harmful to aquatic organisms, risk of long-term adverse effects in aquatic environments
Persistence and Degradability: Slow biodegradation, may persist under normal conditions
Bioaccumulative Potential: Low potential for bioaccumulation expected
Mobility in Soil: Water-soluble, may leach into waterways if released
Other Adverse Effects: Discharge into the environment should be avoided, report spills to authorities

Disposal Considerations

Waste Treatment Methods: Hazardous chemical waste collectors should handle disposal, content should never enter sewers or waterways
Disposal of Packaging: Triple rinse and destroy empty containers, follow local, regional, and national guidelines for hazardous disposal
Legal Requirements: Comply with EPA Resource Conservation and Recovery Act (RCRA) and any local regulations governing hazardous waste

Transport Information

UN Number: 2810 (Toxic solid, organic, n.o.s.)
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains Thioacetamide)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Markings: Label all packages with toxic warning, ensure documentation matches shipping requirements
Special Precautions: Secure tightly, prevent leaks, follow all International Air Transport Association (IATA), International Maritime Dangerous Goods (IMDG), and US Department of Transportation (DOT) requirements

Regulatory Information

OSHA: Listed as hazardous, compliance with 29 CFR 1910.1200 required
TSCA: Listed in US Toxic Substances Control Act Inventory
SARA Title III: Subject to reporting under Section 313 for toxic chemicals
RCRA: Regulated hazardous waste
California Prop 65: Known to state of California to cause cancer
International Regulations: Included in European Union REACH registration, subject to GHS labeling and classification standards in most regions