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Product Name: Tetramethylethylenediamine
Synonyms: N,N,N′,N′-Tetramethylethylenediamine, TMEDA
CAS Number: 110-18-9
Recommended Use: Laboratory chemical, polymerization catalyst, organic synthesis intermediate
Supplier Information: Laboratory supply distributors, chemical manufacturers provide detailed source and emergency phone number on product packaging
Emergency Phone: Listed on label, local hazardous materials response
Address: Available through chemical distributor databases and shipping documents
GHS Classification: Flammable liquids Category 2, Acute toxicity Inhalation Category 4, Eye irritation Category 2A, Skin irritation Category 2
Signal Word: Danger
Hazard Statements: Highly flammable liquid and vapor; causes skin and serious eye irritation; harmful if inhaled; may cause respiratory irritation
Pictograms: Flame, Exclamation mark
Precautionary Statements: Keep away from heat, sparks, open flames, and hot surfaces; use explosion-proof equipment; wear protective gloves and eye protection; use only outdoors or in a well-ventilated area; avoid breathing vapor or mist; wash thoroughly after handling; store locked up
Potential Health Effects: Shortness of breath, headache, skin redness, eye burning, coughing, nausea after inhalation or skin contact
Chemical Name: Tetramethylethylenediamine
Common Name: TEMED
Concentration: >99%
CAS Number: 110-18-9
Impurities: Trace amines, not normally over 0.5%
Molecular Formula: C6H16N2
EC Number: 203-744-6
Eye Contact: Immediately rinse eyes cautiously with water for several minutes; remove contact lenses and continue rinsing; obtain medical attention as soon as possible
Skin Contact: Remove contaminated clothing; wash area with soap and water; seek medical help if irritation persists
Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing; call poison center or physician if feeling unwell
Ingestion: Rinse mouth; do not induce vomiting; seek medical advice if ill feelings develop
Most Important Symptoms/Effects: Severe irritation, headache, dizziness, nausea, burns to mucous membrane in case of direct exposure
Suitable Extinguishing Media: Dry chemical, CO2, alcohol-resistant foam, water spray in small amounts
Hazards from Combustion: Emits toxic fumes such as carbon oxides and nitrogen oxides
Fire-Fighting Instructions: Wear self-contained breathing apparatus; approach fire from upwind side; cool container with water spray
Special Protective Equipment: Structural firefighters coat and gloves, positive-pressure air-mask
Explosion Hazards: Vapors may form explosive mixture with air; containers may explode under fire conditions
Spill Response: Evacuate unnecessary personnel; ventilate area; dike spill with non-combustible absorbent material such as sand or vermiculite
Personal Precautions: Use chemical-resistant gloves, goggles, adequate ventilation, organic vapor respirator when large volume spills occur
Environmental Precautions: Prevent entry into sewers, drains, or natural water sources; notify local authorities if significant quantity enters soil or water
Cleanup Methods: Collect spill with non-sparking tools; place in a chemical waste container; wash contaminated area with water and detergent; dispose of according to local regulations
Safe Handling: Avoid contact with skin and eyes; prevent inhalation of vapors; use anti-static devices; work in a fume hood if possible
Storage Requirements: Store in flammable liquids cabinet away from incompatible substances (oxidizers, acids); tightly closed containers in cool, dry, well-ventilated area
Incompatibilities: Strong acids, oxidizing agents, halogenated compounds
Packaging Materials: Use containers made of stainless steel, glass, or high-density polyethylene
Exposure Limits: ACGIH TLV: 10 ppm; OSHA PEL: Not established; employer should implement workplace monitoring if significant exposures are possible
Engineering Controls: Local exhaust ventilation, safety shower and eyewash station in proximity, explosion-proof ventilation equipment
Personal Protective Equipment: Chemical splash goggles, nitrile or neoprene gloves, long-sleeve lab coat, closed-toe shoes
Respiratory Protection: NIOSH-approved organic vapor respirator for high airborne concentrations
Hygiene Measures: Do not eat, drink, or smoke while handling; wash hands and face before breaks and after use
Appearance: Colorless transparent liquid
Odor: Strong, ammonia-like odor
pH: Alkaline, value above 10 (for a 10% solution)
Melting Point: -55 °C
Boiling Point: 121–122 °C
Flash Point: 17 °C (closed cup)
Evaporation Rate: Moderate, similar to acetone
Flammability: Flammable liquid
Vapor Pressure: Approximately 20 mmHg at 20 °C
Vapor Density: 3.3 (air = 1)
Relative Density: 0.775 g/cm³
Solubility in Water: Miscible
Partition Coefficient (log Kow): -0.5
Auto-Ignition Temperature: 235 °C
Decomposition Temperature: Not available
Viscosity: Low
Reactivity: Stable under recommended conditions; reacts strongly with acids, oxidizing agents
Chemical Stability: Stable at room temperature in sealed containers
Hazardous Reactions: May catch fire or explode if mixed with incompatible chemicals
Conditions to Avoid: Excessive heat, ignition sources, static discharge
Incompatible Materials: Halogens, nitric acid, hydrogen peroxide, strong oxidizers
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides
Routes of Entry: Inhalation, ingestion, skin contact, eye contact
Acute Toxicity: LD50 Oral (rat): 930 mg/kg; LD50 Dermal (rabbit): >8000 mg/kg; LC50 Inhalation (rat, 4hr): 1370 ppm
Symptoms: Respiratory tract irritation, dizziness, headache, skin burns, eye pain and redness
Chronic Effects: No established human data; animal studies show possible liver and kidney changes at high exposure
Sensitization: Potential skin sensitizer
Carcinogenicity: Not listed by IARC, NTP, OSHA
Mutagenicity: No reliable data
Reproductive Toxicity: No reliable data
Ecotoxicity: Toxic to aquatic life; LC50 (fish, 96hr): 93 mg/L; EC50 (daphnia, 48hr): 36 mg/L
Persistence and Degradability: Readily biodegradable under aerobic conditions
Bioaccumulative Potential: Low, log Kow value indicates minimal accumulation
Mobility in Soil: High mobility due to water solubility
Other Adverse Effects: Spills can cause local water pollution; avoid uncontrolled discharges
Product Disposal: Collect and deliver to hazardous waste collection facility; incinerate under controlled conditions in compliance with local, regional, and national regulations
Labeling: Mark container as flammable and toxic organic chemical
Contaminated Packaging: Offer triple-rinsed containers to approved drum reconditioners or metal scrap recovery after complete decontamination
Disposal of Large Amounts: Contact licensed hazardous waste disposer; flushing with water to drain is not recommended
Recycling: Not encouraged for laboratory-scale quantities; industrial processes may recover product for reuse in closed systems
UN Number: 2372
Proper Shipping Name: Tetramethylethylenediamine
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: II
Labels: Flammable liquid symbol
Marine Pollutant: Not classified as a marine pollutant
Special Precautions: Keep containers upright and tightly closed during transport; emergency response guides describe isolation and firefighting procedures
Regulatory Information: Complies with ADR/RID (road/rail), IMDG (sea), IATA (air) shipping rules for dangerous goods
TSCA Status: Listed in the United States Toxic Substances Control Act Inventory
EINECS: Listed in European Inventory of Existing Commercial Chemical Substances
REACH: Registered under European REACH regulations
SARA Title III: Not listed as an extremely hazardous substance; fire hazard under SARA 311/312
WHMIS Canada: Classified as Class B2 (flammable liquid), Class D2B (toxic material)
California Proposition 65: Not identified as a substance known to cause cancer or reproductive toxicity
Other Regulation: Subject to OSHA Hazard Communication Standard in workplaces; users required to maintain safety documentation and provide worker training on chemical handling and exposure risks
