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Sodium Citrate (Anhydrous Pharmaceutical Secondary Standard): Understanding and Relevance

Historical Development

Sodium citrate carries a story deeply rooted in the evolution of applied chemistry and medicine. The discovery of sodium salts in the early 19th century shifted how industries stabilized food, improved medical treatments, and modernized laboratory techniques. In the decades that followed, sodium citrate showed up as a crucial buffer solution, helping control acidity in food products and clinical formulations long before complex synthetic alternatives arrived. Hospitals and laboratories relied on sodium citrate for blood preservation and anticoagulation during surgery, with its role etched into the standards of modern transfusion medicine after World War I. The medical field advanced, but sodium citrate stayed just as important, being part of pharmaceutical preparations, dialysis fluids, and oral medications for over a century, a testament to its steady usefulness and adaptability across changing regulatory times.

Product Overview

In the pharmaceutical field, the anhydrous secondary standard of sodium citrate stands out for its predictable performance and purity. Manufacturing hinges on consistency, with strict quality control, so drug manufacturers keep strict records of source materials. I once worked with a pharmaceutical lab that valued this reproducibility, especially during batch testing or regulatory audits. Secondary standards help laboratories verify the accuracy of analytical results, calibrate instruments, and maintain traceability to primary reference materials. This approach cuts the risk of analytical drift, often seen when using lower-grade materials. Manufacturers cannot afford variation, so they turn to secondary standards like anhydrous sodium citrate, knowing they will not face unpleasant surprises dealing with crucial measurements.

Physical & Chemical Properties

Sodium citrate anhydrous holds specific physical and chemical properties that separate it from its hydrated cousins. The compound presents as a white, odorless crystalline powder, highly soluble in water and only slightly soluble in alcohol. Its melting point exceeds 300°C, which keeps it stable under demanding processing conditions in pharmaceutical or industrial settings. Chemically described as trisodium 2-hydroxypropane-1,2,3-tricarboxylate, it releases citrate ions that interact with phosphates, calcium, and other ions, making it valuable as a buffer or chelating agent. In my time handling lab reagents, its solubility and stable pH performance always made it easy to formulate compared to more temperamental buffering agents.

Technical Specifications & Labeling

Pharmaceutical-grade secondary standards of sodium citrate demand defined parameters reflecting international compendial requirements. Labels must include purity percentage, lot number, expiration date, storage conditions, and a unique identifier for traceability. Some packaging includes a QR code or RFID tag for tracking, which simplifies recall or regulatory reporting. During audits, regulatory agencies want to see Certificate of Analysis with precise impurity profiles and details like loss on drying or heavy metal content. Manufacturers must ensure labels reflect actual product content, or risk non-compliance. Standard operating procedures do not stop at labels: instructions for opening, sampling, and re-sealing must appear on the container itself, preventing unnecessary exposure to humidity and airborne contaminants during everyday use.

Preparation Method

To make anhydrous sodium citrate, chemists react citric acid with an excess of sodium carbonate or sodium bicarbonate in water, then remove the water under controlled heat. The resulting solution undergoes crystallization, preferably at low temperatures to avoid bicarbonate breakdown or unwanted byproducts. Careful filtration and multiple washes eliminate remaining impurities. Drying occurs in vacuum ovens, removing water content without risking decomposition or caking. During earlier years in process development, I saw how overlooked details—such as the speed of temperature ramp or airflow—could alter particle size and residual moisture, influencing how the product dissolves or blends downstream. Scale-up from beaker to production runs rarely stays simple; tight process control ensures each batch measures up to published standards.

Chemical Reactions & Modifications

Sodium citrate readily forms complexes with calcium, magnesium, iron, and other polyvalent ions. This chelation property forms the backbone of its anticoagulant action in blood collection tubes and its function as an ingredient to soften water in detergents or personal care products. In the lab, adding acid or base tweaks its buffering range, helping maintain consistent pH environments despite shifts in concentration. Chemical modifications can insert functional groups or produce new salts: mixing with aluminum or potassium salts creates hybrid substances for specific industry needs. Many research processes depend on sodium citrate’s reactivity, such as nanoparticle synthesis or DNA extraction, where its ability to stabilize or modify the reaction milieu proves indispensable.

Synonyms & Product Names

Across the globe, sodium citrate anhydrous shows up under many names: Trisodium citrate, Citrosodine, Citrosal, E331, and Natrium citricum. Pharmacopoeias and regulatory documents often reference these alternate names, so scientists and procurement staff stay alert to avoid costly mix-ups. In retail markets, the ingredient list of processed foods and pharmaceuticals may list “sodium citrate” without the hydration state, but technical documents in manufacturing or laboratory testing always specify the exact form and grade. The European Pharmacopoeia, US Pharmacopeia, and other authorities occasionally update nomenclature, requiring product managers to cross-check every shipment, reducing errors at order or compliance review.

Safety & Operational Standards

Safe handling remains front-of-mind for laboratory and factory staff who interact with sodium citrate daily. Material Safety Data Sheets indicate low acute toxicity, though prolonged skin or eye contact can cause mild irritation. Direct inhalation of dust during weighing or mixing in production environments must be minimized by using fume hoods or local exhaust systems. Storage areas need well-sealed containers—often HDPE drums or lined steel bins—away from strong acids or moisture sources. During one summer internship at a contract manufacturer, I saw the long-term impact of minor protocol lapses, as exposure to damp not only ruined the powder’s usability but seeded batch-to-batch variability. Employees require annual chemical handling training, and supervisors keep spill kits, neutralizers, and emergency eyewash stations close to all raw material staging areas. Adherence to Good Manufacturing Practices upholds both worker safety and product integrity.

Application Area

The reach of sodium citrate anhydrous extends into just about every major sector of healthcare and consumer goods. In hospitals, it acts as a blood anticoagulant, supporting safe blood storage and reliable laboratory values during diagnostic testing. In the food industry, sodium citrate regulates acidity and keeps cheese, soft drinks, and processed meats safe and palatable. It plays a quiet, but vital, role in formulating effervescent tablets, injectable solutions, and oral suspensions, balancing palatability and chemical stability. Specialty industrial processes—think textile dyeing, electroplating, biomaterial synthesis—depend on its chelating and buffering abilities to keep results predictable. Over years working with quality assurance and R&D teams, I watched project after project choose sodium citrate for its dependability, not just because it checked the regulatory boxes, but because production lines or patient outcomes benefitted from its straightforward chemistry.

Research & Development

Ongoing research demands reliable secondary standards for calibration, especially in pharmaceutical analytics and stability studies. Scientists keep pushing the frontiers, investigating sodium citrate’s roles in drug delivery systems, cancer therapy formulations, and nanoparticle engineering. The compound earned a spot as a stabilizer for silver and gold nanoparticles, opening new paths in medical imaging, antimicrobial coatings, and targeted drug delivery. Clinical research explores modified citrate derivatives to improve biocompatibility or therapeutic effect, with multinational research teams using strict secondary standards to eliminate analytical bias across test sites. By working with product development teams, I learned how minor differences in secondary standard traceability could derail or validate months of analytical work, underlining its importance in research reproducibility and publication credibility.

Toxicity Research

Toxicologists have established that sodium citrate holds a low risk profile at the concentrations used in medicine and food. Animals and clinical studies show a wide margin of safety; oral doses get broken down to harmless metabolites and excreted. Higher doses can cause gastrointestinal discomfort or electrolyte imbalance, underscoring the need for graded dosing and careful product labeling. In laboratory accident scenarios, the compound fails to present acute danger, but chronic ingestion or inhalation should not be dismissed outright. Regulatory agencies keep updating occupational and environmental exposure limits as more data arrives, often requiring manufacturers to conduct or reference fresh toxicological research as part of their annual product reviews. The culture of safety among staff and end-users grows stronger as each generation learns from legacy incidents and applies those lessons to new technologies and formulations.

Future Prospects

Over the next decade, sodium citrate’s profile looks set to expand as regulatory bodies demand even tighter standards for pharmaceutical and food production. Advances in green chemistry push for more sustainable production routes and analytical methods with reduced environmental impact. Scientists keep probing ways to harness its properties for new drug formulations, diagnostic tools, and advanced biomaterials. Supply chain disruptions, such as those experienced during recent global crises, motivate companies to localize production and advance real-time traceability with digital solutions. I predict a shift toward customization, with manufacturers offering tailored grades for emerging therapies in regenerative medicine, cell culturing, or precision diagnostics, reinforced by rigorous data on reproducibility and environmental footprint. Research labs, manufacturers, regulators, and clinicians work together to ensure that sodium citrate keeps its reputation for reliability, safety, and broad applicability, regardless of how methods or markets evolve.




What is Sodium Citrate (Anhydrous Pharmaceutical Secondary Standard) used for?

Where Sodium Citrate Shows Up in Real Life

Sodium citrate sounds pretty technical, but it’s actually familiar to anyone who’s opened a sports drink or tried certain processed cheeses. In the world of medicine, its role shifts from flavor to function. Here, sodium citrate isn’t about taste—it’s all about controlling acidity, preserving compounds, and making sure drugs work reliably.

Think back to a time you had a lemon with a cut. The sting happens because acid reacts with your skin. In pharmaceuticals, uncontrolled acid can mess up how a medication works. Sodium citrate keeps things stable. For labs and manufacturers, sodium citrate (anhydrous, pharmaceutical grade) becomes a yardstick—every batch compares back to this reference so results make sense. Reproducibility can save doctors from playing guesswork with patient safety.

How the Standard Matters

Quality control isn’t the most thrilling side of medicine, but there’s a good story behind it. Years ago, I spoke with a pharmacist who explained how a batch of IV solution that shifted too far in pH caused discomfort for patients. It took multiple rounds of adjustments and wasted resources. Most hospitals can’t afford to pull medicines off the shelves over uncertainty. They need tight standards. That’s where this version of sodium citrate steps in and keeps products within safe, reliable limits.

Sodium citrate also acts as an anticoagulant, which means it keeps blood from clotting in tubes. Blood banks and hospitals rely on it to make sure samples remain usable and accurate during analysis. Messy blood results can throw off treatment for thousands. If the reference standard isn’t reliable, entire tests risk going sideways. Sodium citrate's consistency isn’t just nice to have—it’s non-negotiable for patient care.

Looking at Risks and Solutions

Pharmaceuticals face recalls when their raw materials don’t stack up. Faulty sodium citrate leads to broad problems, especially in settings like kidney care, where it’s used to filter blood. One news story from 2022 highlighted a shipment that missed the mark and forced clinics to scramble for alternatives. Every time raw materials waver in quality, confidence drops and costs climb. Care depends on trust in these materials, and that trust comes from repeatable, third-party-tested standards.

The trouble is supply lines get stretched, and not every supplier matches strict benchmarks. Regulators like the FDA keep an eye on imported and domestic batches. Spot-checking remains the norm, but batch-level testing with reference-grade sodium citrate gives labs a safety net. Investing here pays off. Pharmaceutical companies also benefit from supporting supplier audits and demanding transparent results. If those in charge settle for “close enough,” the whole medical ecosystem pays the price.

Why It Matters for Everyday People

For patients, the details don’t always matter—until a medicine doesn’t act like it should. I’ve seen friends wonder why two rounds of the same generic drug produced different results. Tracing that difference back sometimes leads to ingredients like sodium citrate. For families relying on steady, predictable care, the work that goes into setting and meeting these standards stays hidden but remains incredibly important.

Sodium citrate as an anhydrous pharmaceutical secondary standard might never be a household name. Behind the scenes, though, its presence ripples through every IV, blood draw, and batch of medication aimed at healing and helping. No shortcuts, just science and trust, batch after batch.

How should Sodium Citrate (Anhydrous) be stored?

Staying Fresh: Why Storage Choices Matter

Walk into any lab or food production space, and you'll spot a tub or bag of sodium citrate tucked away somewhere. This fine, white powder makes its way into cheese, soda, and even medical labs. Keeping it pure and reliable can be the difference between a recipe that works and a setback that sends operations spinning. Most folks notice very quickly—if you don’t treat sodium citrate with the right respect, you’ll end up with clumps, contamination, or a total loss of usability.

Moisture: The Constant Enemy

Sodium citrate anhydrous draws water from the air, almost like a magnet. Even a mildly damp environment causes this compound to cake or harden. That creates issues with measuring, blending, and, frankly, peace of mind. I remember opening a loosely sealed bag during a humid stretch—what poured out looked more like wet sand than the smooth, dry powder I started with. So, dry storage isn’t just a best practice. It’s the only way to avoid product waste and inconsistent results.

Keep It Cool and Dark

Direct sunlight and heat can wear down sodium citrate, even though it doesn't burn easily. Light and heat speed up degradation, making the powder less effective over time. Normal room temperature, out of direct sunlight, will do the job. Cool, dry cabinets or shelving units offer a simple solution. In food and lab work alike, cross-contamination quickly snowballs into expensive or even dangerous mistakes. Choosing storage away from acid, strong odors, or corrosive substances helps protect both quality and safety.

Seal It Tight—Don’t Give Spoilage a Chance

I’ve lost count of people who toss sodium citrate in a flimsy plastic bag, roll it up, and call it stored. That approach brings on moisture and accidental spills, both of which take dollars and time out of your pocket. Sturdy containers, either airtight plastic or glass jars, help keep out the air and moisture. If you’re storing bulk, multiple smaller containers beat a single huge one; each time the container opens, the leftover powder sees more moisture and air. Smaller batches keep the rest protected.

Label Everything

Accuracy matters whether you’re working in a kitchen or a clinic. Clear labeling with the purchase date, batch number, and lot details sets you up for traceability and safety. I once worked in a facility where two powders looked nearly identical. One quick look at the label kept the team out of a bad mix-up. Also, this simple step saves time and confusion, especially once several additives stack up on the same shelf.

Handling and Hygiene: Low-Tech, High Impact

Clean, dry spoons or scoops are your friends. Dirty or wet scoops introduce mold, bacteria, and clumps, quickly creating headaches for everyone. Using fresh utensils each time sounds basic, but it’s a habit that pays off. Wearing gloves or washing hands first (if direct handling comes into play) protects both the product and anyone using it later.

Disposal: Protecting People and the Environment

Spills and outdated stock go right in the trash if small, following local safety guidance. You shouldn't wash significant quantities down the drain. Even at the end of its lifecycle, sodium citrate deserves mindful treatment to avoid contaminating waterways and public spaces.

Keeping Sodium Citrate Reliable

From food safety to chemical reaction reliability, storing sodium citrate correctly keeps output consistent and dependable. It doesn’t take fancy gear or big budgets—just smart storage, airtight containers, and careful handling. Paying attention to a few simple steps saves time, money, and trouble down the line—something every production space, lab, or hobbyist operation can appreciate.

What is the purity of Sodium Citrate (Anhydrous Pharmaceutical Secondary Standard)?

Digging Into the Question of Purity

Sodium citrate ends up in labs, clinics, even in big food operations, but here the focus sits on the pharmaceutical-grade, anhydrous, secondary standard type. This niche powder isn’t just another kitchen ingredient — it comes with strict requirements. Pharmaceutically, purity isn’t a vague idea. It marks the difference between a safe product and a questionable one. The Pharmacopeia — think United States Pharmacopeia (USP) and European Pharmacopoeia (Ph. Eur.) — lays down the law. For sodium citrate anhydrous locked into pharmaceutical standards, purity should hit at least 99.0% on a dried basis, sometimes pushing even higher. Any batch trailing below that mark would cause trained eyes to look twice.

Why So Much Fuss Over One Decimal?

People often overlook trace impurities. Lab staff know there’s a world between 99% and 97%. If you take a blood sample, run a dialysis machine, or swallow a buffered tablet, you want every bit of control possible. Even a pinch of heavy metals or errant chloride ions below set limits means added risks — maybe not today, but over years or millions of doses, those risks compound. Food-grade material sometimes sits at a lower threshold, yet what works in lemon sorbet does not belong in a medicine bottle.

How Testing Keeps Sodium Citrate Honest

Labs run sodium citrate powder through the gauntlet before it’s approved. Titration checks the sodium content with tight margins. Loss on drying confirms all water gets chased out, matching the standard. UV and infrared spectrometry peer into the powder’s molecular closet, making sure no troublemakers sneak along for the ride. Anyone in quality control has watched reams of results go by, and watched colleagues toss entire shipments in the trash for a missing 0.5%. No one wants to risk a patient’s safety to save a buck.

People might assume that a pharmaceutical standard never gets breached, but mistakes creep in. Poor shipment storage or accidental mix-ups can let in contaminants. Having trustworthy suppliers means almost as much as the quality checks. Companies count on rigorous paperwork, strong staff training, and repeat testing. Falsified or incomplete details lead to catastrophic recalls. At every step, traceability remains king.

Living With High Purity: Why It Matters Daily

Anyone who’s handled intravenous injections or made dialysis solutions knows the value of that 99+% purity. Imagine a dialysis patient whose blood goes in and out of a machine dozens of times a month; the tiniest heavy metal contamination becomes significant across multiple exposures. Some hospitals only work with pharmacists who demand recent certificates of analysis showing every analyte — sodium, citrate, iron, lead — reported beneath tough limits.

Work flows better with strong standards. There’s less guesswork, fewer phone calls about murky product labels, and more confidence asking regulators tough questions. Even outside the hospital, compounding pharmacies rely on that pharmaceutical standard so they can give patients peace of mind with every dose.

Staying Ahead: Solutions Beyond Paperwork

Reliability grows from more than documentation. Onsite audits, well-trained staff, deep supplier relationships, independent lab confirmation — these build solid ground. Watching colleagues run spot checks, double-check supplier records, or challenge a shipment’s paperwork may look obsessive, but each step means another patient gets medicine that does only what it’s supposed to. If a batch drops below 99% or tips above allowed residual solvents, the best outcome is catching it before reaching the patient.

Experience says solid purity keeps everyone safer, not just on paper but in every hospital round and every home pillbox. This is not a bureaucratic hurdle; it’s the result of years of hard lessons and patient stories.

Is Sodium Citrate (Anhydrous) safe for consumption or pharmaceutical use?

Putting Sodium Citrate on the Table

Anyone who has sprinkled processed cheese on pasta or taken an antacid tablet probably encountered sodium citrate, even without knowing it. This salt steps into recipes and medicines to bring out flavors, improve texture, or settle stomach acid. Many people – including myself – once read the back of a powdered sports drink or a pharmacy bottle and paused at the line: “Sodium Citrate (Anhydrous).” Curiosity or concern follows. Is it safe?

Backing from Health Authorities

Health authorities take food additives and medicine ingredients seriously. Both the U.S. Food and Drug Administration (FDA) and European Food Safety Authority (EFSA) have reviewed sodium citrate thoroughly. These groups expect testing for toxicity and behavior in the human body. Sodium citrate is approved for direct food use and pharmaceutical production at levels far above what anyone would consume on a typical day.

Reports from medical journals and regulatory reviews, including research from the World Health Organization, suggest that sodium citrate leaves the human body without causing damage. The kidneys process and remove extra sodium and citrate, turning these byproducts into harmless forms. I’ve read statements from dietitians who explain that the body transforms citrate into bicarbonate, which then helps control acidity. Folks with healthy kidneys usually process sodium citrate without any fuss.

Potential Issues: Who Should Pay Attention

Though most people face little risk from the levels found in food and medicines, there are some exceptions. People on sodium-restricted diets, often because of heart or kidney disease, might need to keep an eye out. Every pinch of sodium counts and sodium citrate delivers a dose. Health care providers often recommend extra caution for this group. High intake may cause water retention, swelling, or higher blood pressure – all things to avoid with these conditions.

Children with rare metabolic disorders called renal tubular acidosis may use sodium citrate under a doctor’s supervision. The prescribed doses are calculated for their needs and doctors will follow up to prevent problems. In these cases, sodium citrate acts as medicine, balancing blood acid levels and avoiding dangerous shifts. Most people never face these medical edge cases, but those who do should keep their care team in the loop.

Taste, Stability, and Shelf Life

From a food point of view, sodium citrate tweaks the flavor in drinks and dairy. It keeps processed cheese smooth and meltable by stopping the proteins from clumping together. In pharmaceuticals, it offers stability and can improve how well a product stores in the medicine cabinet. I remember as a kid, flavored medicine syrups on the shelf rarely separated or changed. Sodium citrate likely played a role in making sure every teaspoon stayed the same – for months after opening the bottle.

Responsibility and Practical Limits

Manufacturers and regulators set strict rules for the total amount of sodium citrate used in foods and over-the-counter drugs. Labels let consumers make informed choices – especially if they have health conditions that make sodium intake tricky. For healthy adults and children, ingesting reasonable amounts from ordinary diets doesn’t throw off the balance in the body. Still, no one benefits from loading up on processed foods. It always makes sense to scan ingredient lists, ask your doctor if you’re unsure, and stick to whole foods where possible.

Looking Forward: Transparency and Ongoing Review

Companies developing new foods and medicines must submit their research before a product lands on shelves. Review panels check short-term and long-term safety, plus the impact on special groups. Research teams around the world keep tabs on additives like sodium citrate, updating guidance if new risks appear. People deserve clear information and a chance to make up their own minds – with trusted facts leading the way.

What are the main specifications and quality standards of this product?

Understanding the Real Benchmarks

Buying a product that claims to meet industry standards only takes you so far. Most people, including myself, want to know: does it actually deliver what’s promised, is it safe to use, and will it last? That’s where real specifications and solid quality standards come in. Years ago, I learned the hard way that cutting corners on proven specs leads to more headaches down the line—whether we're talking about electronics, food, or machinery.

Core Specifications—What Does the Product Offer?

The backbone of every reliable product starts with clear technical details. These often include material composition, physical dimensions, performance characteristics, and tolerance levels. If we’re looking at a tech gadget, things like processor speed, battery life, display type, and compatibility set expectations. For consumer goods like nutritional supplements, actual dosage, purity, and ingredient sourcing take center stage.

Consistent labeling, honest advertising, and transparent data sheets provide the information buyers rely on. For example, a reputable electronics manufacturer publishes standardized test results measuring everything from energy consumption to drop resistance. In the food industry, clear ingredient lists and origin details build trust. When companies fall short, it’s usually easy to trace back to vagueness or lack of third-party checks.

Quality Standards—How Trust is Built and Maintained

Industry standards shape the rules, but customer trust runs deeper. In practice, solid quality standards mean that each batch or unit matches what was promised—not just once, but every time. That comes from repeatable production processes, frequent quality checks, and documented compliance with independent standards. Certifications like ISO 9001 or safety seals from trusted labs help sort serious manufacturers from the rest.

In my own experience, dealing with batch-to-batch inconsistency leads straight to lost customers and extra costs. Consider the auto industry: parts sourced from suppliers with verified certifications reduce recalls. For medical products, purity standards and contamination controls protect patients. Businesses that take shortcuts might save money up front but pay for it later in damaged reputation.

Fact-Based Insight

According to a 2023 report from the International Organization for Standardization, products that follow published standards see fewer recalls and consumer complaints by more than 35%. A study from Harvard found that clear product documentation reduces user errors and customer service calls by nearly half. These trends play out across smartphones, packaged food, complex machinery, and beyond.

Over the last decade, increased government oversight and improved consumer education raised the bar. Stories about faulty batteries or mislabeled foods remind us that real lives depend on accurate specifications and honest standards.

Better Solutions for Future Quality

Manufacturers committed to improvement gather feedback directly from real users, then adapt specs and testing methods. Lean production methods and digital tracking—think QR codes with batch data or cloud-based record keeping—help ensure every item matches expectations. Partnering with independent labs for surprise checks keeps suppliers honest, too.

For buyers, reading reviews, checking third-party certifications, and reaching out to customer service for detailed specs go a long way. Regulators could push for more accessible safety data and punish those who mislead. In short, demanding transparency and proven results helps everyone from the factory floor to the family kitchen.

Sodium Citrate (Anhydrous Pharmaceutical Secondary Standard)
Names
Preferred IUPAC name Trisodium 2-hydroxypropane-1,2,3-tricarboxylate
Other names Citrosodine
Trisodium citrate
Sodium citrate tribasic
Citric acid, trisodium salt
E331
Sodium citrate anhydrous
Pronunciation /ˈsəʊdiəm ˈsɪtreɪt/
Identifiers
CAS Number 68-04-2
Beilstein Reference 3568701
ChEBI CHEBI:63034
ChEMBL CHEMBL1357
ChemSpider 4999
DrugBank DB04045
ECHA InfoCard 0422-037-00-2
EC Number 200-675-3
Gmelin Reference 60794
KEGG C00735
MeSH D017366
PubChem CID 6224
RTECS number WHXLQ*JC9*
UNII QTT17582CB
UN number “UN1759”
Properties
Chemical formula Na3C6H5O7
Molar mass 258.07 g/mol
Appearance White crystalline powder.
Odor Odorless
Density 1.7 g/cm³
Solubility in water Soluble in water
log P -3.5
Vapor pressure Vapor pressure: <0.1 hPa (20 °C)
Acidity (pKa) 3.1
Basicity (pKb) 1.7 (pKb)
Magnetic susceptibility (χ) -63.0×10⁻⁶ cm³/mol
Refractive index (nD) 1.364
Dipole moment 0 D
Thermochemistry
Std molar entropy (S⦵298) 209.7 J·mol⁻¹·K⁻¹
Std enthalpy of formation (ΔfH⦵298) -1614 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -2207.6 kJ/mol
Pharmacology
ATC code B05CX
Hazards
Main hazards Not hazardous.
GHS labelling GHS labelling: GHS07
Pictograms GHS07, GHS09
Signal word Warning
Hazard statements May cause respiratory irritation.
Precautionary statements Keep container tightly closed. If in eyes: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. If skin irritation occurs: Get medical advice/attention.
NFPA 704 (fire diamond) 1-0-0
Flash point Flash point: >100°C
Lethal dose or concentration LD50 oral rat: 8,400 mg/kg
LD50 (median dose) LD50 (median dose): Oral - rat - 8,400 mg/kg
NIOSH VZ0850000
PEL (Permissible) PEL (Permissible): Not established
REL (Recommended) '500 mg/kg bw'
IDLH (Immediate danger) Not listed
Related compounds
Related compounds Citric acid
Trisodium citrate dihydrate
Monosodium citrate
Disodium citrate
Potassium citrate