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Chemical Name: Sildenafil Citrate
Common Name: Viagra
Recommended Use: Treatment of erectile dysfunction, pulmonary arterial hypertension
Chemical Formula: C22H30N6O4S·C6H8O7
Appearance: White or slightly off-white powder
Odor: Odorless
Solubility: Freely soluble in water and DMSO, sparingly soluble in methanol
Molecular Weight: About 666.7 g/mol
Health Hazards: Potential for eye irritation, skin irritation, and respiratory tract effects with dust exposure; may cause dizziness, headaches, nasal congestion, and gastrointestinal disturbance.
Physical Hazards: Stable under normal conditions, combustible in fire
Environmental Hazards: Noted potential risk to aquatic environments, particularly with improper disposal
Signal Words: Caution for laboratory and manufacturing workers due to pharmaceutical activity
Hazard Statements: Risks increase with ingestion or excessive occupational inhalation
Main Constituent: Sildenafil citrate, pharmaceutical-grade at concentrations above 95%
Impurities or Additives: Less than 5%, often residual solvents and byproducts from synthesis
Inactive Ingredients: Occasionally traces from manufacturing, not expected in pure raw product
Inhalation: Remove from exposure, provide fresh air, monitor for symptoms such as coughing or shortness of breath
Skin Contact: Remove contaminated clothing, wash thoroughly with soap and water
Eye Contact: Rinse cautiously with water for several minutes; seek medical attention for persistent irritation
Ingestion: Rinse mouth, seek medical treatment, do not induce vomiting without medical advice
Medical Attention: Treatment should focus on symptom relief and supportive care
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, foam, water spray
Fire Hazards: Thermal decomposition produces hazardous fumes such as nitrogen oxides, carbon oxides, and sulfur oxides
Fire-Fighting Precautions: Firefighters need self-contained breathing apparatus, protective gear, avoid inhaling combustion gases
Special Hazards: Product dust can cause risk of explosion in rare cases where airborne concentrations are high
Personal Precautions: Use personal protective equipment such as gloves, goggles, and dust mask
Environmental Precautions: Prevent spills from entering drains, sewers, surface water, or soil
Clean-Up Methods: Collect spilled material using non-sparking tools, place in sealed container, ventilate area
Decontamination: Wash area with plenty of water, dispose of cleaning materials safely
Safe Handling: Avoid dust generation, keep away from food and drink, practice good hygiene
Storage Conditions: Store in a cool, dry, well-ventilated place, keep container tightly closed
Incompatibilities: Keep away from strong oxidizers and acids
Recommended Storage Temperature: Room temperature, away from sources of ignition or direct sunlight
Exposure Limits: No established occupational exposure limit, but minimizing exposure makes sense to avoid accidental effects
Engineering Controls: Adequate ventilation or local exhaust systems in manufacturing areas
Personal Protective Equipment: Gloves, safety glasses, lab coats for handling bulk material
Respiratory Protection: Dust mask or respirator for large-scale operations
Physical State: Solid powder
Color: White or off-white
Melting Point: Around 187-189°C
Boiling Point: Not easily applicable for solid pharmaceutical
Solubility in Water: Freely soluble
pH (1% Solution): Slightly acidic to neutral
Odor Threshold: Not applicable due to odorless property
Vapor Pressure: Negligible for practical purposes
Reactivity: Low chemical reactivity in storage
Chemical Stability: Stable at normal temperatures and pressures
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide seen on combustion
Incompatible Materials: Strong oxidizers, strong acids
Hazardous Reactions: None expected under recommended conditions of use
Routes of Exposure: Inhalation, skin, eyes, ingestion
Acute Effects: Dizziness, headache, mild hypotension, nasal congestion, or gastrointestinal upset at therapeutic doses; risk increases with occupational overexposure
Chronic Effects: Possible impact on cardiovascular health if exposure is repeated and uncontrolled; long-term carcinogenicity not clearly established
Allergic Reactions: Rare, but rash or hypersensitivity reactions have occurred
Animal Studies: Data available on reproductive and developmental toxicity; high doses produced adverse effects in lab animals
Mutagenicity: No clear evidence of cardiac or genetic toxicity in typical exposure scenarios
Aquatic Toxicity: Evidence suggests some risk to aquatic organisms, especially when disposed of in large or concentrated amounts
Persistence and Degradability: Not readily biodegradable, can linger in the environment
Bioaccumulation: Expected to be low, but data remains limited
Environmental Concerns: Pharmaceutical waste in water bodies can disrupt aquatic ecosystems, including affecting breeding and behavior in fish
Safe Disposal: Dispose of as pharmaceutical waste
Prohibited Disposal: Avoid disposing in general trash or down the drain
Preferred Methods: Incineration by licensed waste contractor, or landfill if containment and monitoring exist
Environmental Protection: Collection programs and take-back schemes improve environmental and public safety
Shipping Name: Not typically classified as hazardous for transport in small quantities
Packing Group: No special requirements for road, air, or sea transport in finished forms
Special Precautions: Protect from moisture and breakage; large-scale shipments should comply with international pharmaceutical transport standards
Regulated Status: Prescription drug in most jurisdictions; controlled under pharmaceutical regulations but not classified under major chemical hazard frameworks like OSHA or GHS in its final tablet form
Worker Protection: Pharmaceutical manufacturing sites enforce safety protocols for dust and exposure
Disposal and Release Laws: Environmental protection regulations govern disposal; improper disposal can bring penalties
Labeling: Laws mandate controlled labeling for pharmaceutical use, warnings for adverse effects, secure storage
