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Product Name: RPMI-1640 Medium
Synonyms: Roswell Park Memorial Institute Medium, RPMI 1640
Product Code: Varies by manufacturer
Intended Use: Laboratory chemical for cell culture
Manufacturer: Refer to product packaging
Recommended Use: In vitro cell maintenance and growth assays
Emergency Phone Number: Refer to manufacturer’s contact sheet
Address: See supplier information on label
Date of Preparation or Revision: Consult latest provided document
Classification: According to GHS, not classified as hazardous
Main Hazards: Non-hazardous under normal laboratory use; inhalation of powders may cause mild respiratory irritation; eye contact could cause transient discomfort; ingestion is not likely to result in acute effects due to low toxicity
Health Risks: Low, though persons with known allergies to certain ingredients should practice caution
Label Elements: No pictogram required; signal word not applicable; hazard statements not required
Precautionary Statements: Use personal protective equipment; prevent ingestion or inhalation of powder; avoid direct contact with skin and eyes
Essential Ingredients: Inorganic salts (sodium chloride, potassium chloride, calcium nitrate, magnesium sulfate, sodium bicarbonate), amino acids (L-glutamine, L-arginine, glycine, L-histidine, L-isoleucine, L-leucine, L-lysine, L-methionine, L-phenylalanine, L-serine, L-threonine, L-tryptophan, L-tyrosine, L-valine), vitamins (biotin, folic acid, thiamine, riboflavin, nicotinamide, pyridoxine, vitamin B12, ascorbic acid, inositol), D-glucose, phenol red (for pH indication), sodium pyruvate; the concentration of each component available from the technical data sheet by manufacturer
Formulation: Powder or prepared solution, depending on purchase
CAS Numbers: Refer to the ingredient list provided by the supplier
Hazardous Components: None present above threshold for hazardous classification according to GHS
Inhalation: Move affected person to fresh air; seek medical attention for symptoms
Eye Contact: Rinse immediately under running water for fifteen minutes; remove contact lenses if present; obtain medical assistance if irritation persists
Skin Contact: Remove contaminated clothing; wash with soap and water thoroughly
Ingestion: Rinse mouth, do not induce vomiting; drink water to dilute if person is conscious; seek advice from health professional
Symptoms: May cause mild and transient irritation to eyes, respiratory tract, or skin
Most Important Symptoms: Itching, watery eyes, slight cough possible upon inhalation of dust
Flash Point: Not flammable
Suitable Extinguishing Media: Water spray, foam, dry powder, carbon dioxide
Hazardous Combustion Products: May release carbon monoxide, carbon dioxide, nitrogen oxides if decomposed at high temperatures
Special Protective Equipment: Wear full protective gear with self-contained breathing apparatus
Specific Hazards: Containers close to fire may rupture due to heat, minimize dust generation with gentle handling
Personal Precautions: Avoid creating dust; ventilate area; wear appropriate protective gear including gloves and safety glasses
Environmental Precautions: Keep material out of sewers and open water sources
Spill Clean-Up: Scoop up powder with damp cloth or absorb solution with inert material; clean area thoroughly with water; dispose according to local laws
Handling: Avoid breathing dust; prevent ingestion and skin or eye contact; use in well-ventilated area
Storage: Stack sealed containers in dry, cool, well-ventilated space; avoid direct sunlight; maintain temperatures between 2–8°C if in solution, or as advised by supplier; keep away from incompatible chemicals; keep tightly closed to protect from moisture or contamination
Engineering Controls: Use laboratory fume hood or other local exhaust for powders
Eye Protection: Chemical safety goggles
Hand Protection: Disposable laboratory gloves, nitrile preferred
Skin Protection: Wear lab coats or aprons
Respiratory Protection: Particle mask in case of inadequate ventilation
Hygiene Measures: Wash hands thoroughly after handling; avoid contact with eyes and skin; do not eat, drink, or smoke in laboratory areas
Appearance: White to pinkish powder or reddish-pink liquid (due to phenol red indicator)
Odor: Neutral or slight, non-offensive
Odor Threshold: Not applicable
pH: ~7.2–7.4 for solution
Melting Point/Freezing Point: Not applicable
Boiling Point/Range: Not determined
Flash Point: Not flammable
Evaporation Rate: Not determined
Solubility: Fully soluble in water
Vapor Pressure: Not relevant
Density: ~1 g/mL for liquid solution
Partition Coefficient: Not determined
Chemical Stability: Stable under recommended conditions of storage
Reactivity: Non-reactive in normal laboratory conditions
Possibility of Hazardous Reactions: Will not polymerize; unlikely to react dangerously with water or air
Conditions to Avoid: Excessive heat, contact with strong acids or oxidizing agents, moisture exposure if in powder form
Incompatible Materials: Strong acids, strong oxidizers
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides under high-temperature decomposition
Routes of Exposure: Inhalation, skin and eye contact, ingestion
Acute Toxicity: No information indicating significant toxicity at small concentrations typical for laboratory work
Chronic Toxicity: No chronic health effects expected; no carcinogenic, mutagenic, or reproductive hazards reported
LD50/LC50: Not established for this mixture
Symptoms: Mild irritation to mucous membranes possible upon large exposure
Medical Conditions Aggravated by Exposure: No specific risk identified
Ecotoxicity: Not expected to significantly affect aquatic or terrestrial environments at typical lab quantities
Persistence and Degradability: Readily biodegradable due to organic nutrient content
Bioaccumulative Potential: No significant potential due to rapid microbial and environmental breakdown
Mobility in Soil: Fully soluble, unlikely to adsorb strongly to soil particles
Other Adverse Effects: None known in standard use or disposal volumes
Waste Treatment: Dispose through laboratory chemical waste collection, following local, state, and federal regulations for non-hazardous waste
Method of Disposal: Small quantities can be diluted and rinsed to drain in accordance with legal guidelines; bulk waste should be labeled and handed to waste disposal vendor
Contaminated Packaging: Rinse before recycling or disposal where permitted by regulations
UN Number: Not regulated
UN Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Non-hazardous for road, air, or sea shipment
Packing Group: Not required
Environmental Hazards: No direct hazard identified
Special Precautions for User: Prevent container breakage or leakage; keep sealed; secondary containment for bulk amounts
International Inventories: All components listed or exempted from main inventory lists (TSCA, REACH, DSL, AICS, ENCS, etc.)
US Regulations: No component meets OSHA or SARA 313 thresholds
EU Regulations: Not listed as a hazardous mixture under CLP
Labeling Requirements: No hazard pictograms or risk phrases required for these concentrations; informational labeling suggested for good practice
Other Regulatory Restrictions: None for common laboratory application
