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Product Name: RPMI-1640 Medium (Hybrimax)
Product Code: R8758 (or as labeled by the supplier)
Manufacturer: Sigma-Aldrich (offices worldwide)
Synonyms: Roswell Park Memorial Institute Medium 1640, Hybridoma 1640 Medium
Chemical Family: Buffered Salt Solution with Amino Acids, Vitamins, and Glucose
Intended Use: Cell culture applications, laboratory research use only
Supplier Contact: Emergency phone and technical support line numbers listed on product label
Classification: Not classified as hazardous according to GHS standards for laboratory chemical mixtures
Main Hazards: May irritate eyes, skin, and respiratory tract if inhaled or exposed in large amounts
Signal Word: None
Hazard Statements: Not expected to be hazardous under normal handling, though dust can cause mechanical irritation
Precautionary Statements: Avoid inhalation, ingestion, and prolonged skin contact; Prevent contact with eyes
Symptoms of Overexposure: Mild irritation to skin or mucous membranes, mild eye redness, discomfort to sensitive individuals
Main Components: Inorganic salts (Sodium chloride, Potassium chloride, Calcium chloride, Magnesium sulfate, Sodium bicarbonate), D-glucose, L-glutamine, Amino acids (e.g., L-arginine, L-asparagine, L-histidine), Vitamins (choline chloride, riboflavin, nicotinamide), Phenol red
CAS Numbers: Mixture
Proprietary Mixture: Individual concentrations vary, all components at concentrations suitable for mammalian cell culture
Additional Ingredients: May contain antibiotics or additives according to product variant
Physical State: Powder or liquid
Inhalation: Move person to fresh air; Seek medical attention if breathing becomes difficult or irritation persists
Skin Contact: Wash skin thoroughly with soap and water; Remove contaminated clothing
Eye Contact: Rinse eyes thoroughly with water for at least 15 minutes, hold eyelids apart; Seek medical attention if irritation continues
Ingestion: Rinse mouth, do not induce vomiting; Get medical advice if large quantity swallowed or symptoms appear
Notes to Physician: Treat symptomatically, no antidote necessary
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical powder, or foam
Unsuitable Media: Not known
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides, hydrogen chloride fumes
Protective Equipment: Firefighters wear self-contained breathing apparatus and protective suit
Fire Hazards: Non-combustible in original state; Packaging materials may burn
Advice for Firefighters: Remove product from fire area if safe, prevent runoff from firefighter efforts from reaching water bodies
Personal Precautions: Use personal protective equipment such as gloves, safety goggles, dust mask if needed
Environmental Precautions: Prevent entry into drains, sewers, or water sources
Cleanup Procedures: Sweep up, scoop, or vacuum inert material; Avoid dust generation; Place into suitable waste containers for disposal
Decontamination: Rinse spill site with water after material removal; Ventilate area
Notification: Large spills may need notification to environmental authorities based on local regulations
Handling: Work in well-ventilated area; Avoid creating or breathing dust or aerosols; Use standard laboratory practices
Hygiene Measures: Wash hands after handling; Do not eat, drink, or smoke in laboratory area
Storage Conditions: Store tightly closed in original container, in a cool, dry, well-ventilated place; Protect from moisture and heat
Incompatibilities: Strong oxidizing agents
Special Handling Instructions: Keep container tightly sealed; Avoid direct sunlight and freezing (if liquid)
Engineering Controls: Use in laboratory fume hood or with local exhaust ventilation; Maintain airborne concentrations below nuisance dust limits
Personal Protective Equipment: Safety goggles or face shield, laboratory gloves (nitrile, latex), lab coat
Respiratory Protection: Not usually needed for routine use. Filter mask (P2 or N95) if dust/aerosol generation cannot be avoided
Hand Protection: Nitrile or latex gloves
Eye Protection: Safety goggles with side shields
Environmental Exposure Controls: Prevent product release into environment
Appearance: Fine powder (off-white to pinkish) or clear pink-red liquid
Odor: Odorless
pH: 7.0–7.4 at recommended dilution
Melting Point / Range: Not applicable (powder); Can freeze (liquid below 0°C)
Initial Boiling Point and Range: Not applicable
Solubility: Soluble in water
Vapor Density: Not applicable
Relative Density: Comparable to water (liquid)
Other Data: Not flammable; Stable under normal laboratory conditions
Chemical Stability: Stable under recommended storage and handling conditions
Hazardous Reactions: No hazardous reactions known under normal conditions
Polymerization: Will not occur
Incompatible Materials: Strong oxidizers, acids, alkalis
Decomposition Products: May produce toxic fumes under fire conditions (chlorine, oxides of carbon and nitrogen)
Acute Toxicity: No data suggests significant toxicity to humans; Exposure may produce mild mucous membrane or upper respiratory irritation
Skin Corrosion/Irritation: Mild irritation possible on sensitive individuals
Serious Eye Damage/Irritation: Temporary irritation and redness possible
Sensitization: No data indicates allergic sensitization
Chronic Effects: No ingredients are classified as carcinogenic, mutagenic, or toxic to reproduction at concentrations present
Routes of Exposure: Inhalation, ingestion, eye or skin contact
Ecotoxicity: Expected to have low toxicity to aquatic organisms at concentrations encountered in laboratory use
Persistence and Degradability: Most components are biodegradable or easily hydrolyzed
Bioaccumulative Potential: Negligible for dilute solutions
Mobility in Soil: High mobility for dissolved components; Avoid large-volume release
Other Adverse Effects: Release of large quantities can disrupt natural nutrient balances and promote algal growth in water bodies
Product Disposal: Dispose unused product or waste solution according to local, regional, and national regulations; Treat as non-hazardous laboratory waste
Container Disposal: Rinse containers, dispose through licensed waste contractor
Special Considerations: Do not allow undiluted product to reach groundwater, watercourses, or drains
Recommended Method: Incineration or landfill in accordance with official regulations
Consult: Local authorities for detailed guidance
UN Number: Not regulated
UN Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Not classified
Packing Group: Not applicable
Environmental Hazards: No
Transport in Bulk: Not listed in Annex II of MARPOL 73/78
Special Precautions for Users: Not required
TSCA (USA): Components listed
REACH (EU): Not subject to registration as finished product
WHMIS (Canada): Not controlled
GHS Compliance: Provided as reference for research laboratory handling
Other Regulations: Not subject to hazardous labeling under current US, EU, or other major international chemical safety laws; Employee training required for safe handling
