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Product Name: Ribonuclease A
Synonyms: RNase A, Pancreatic ribonuclease
CAS Number: 9001-99-4
Recommended Use: Laboratory reagent in molecular biology research
Supplier Details: Biochemical supply companies, research laboratories, distributors of life sciences products
Emergency Contact: Refer to supplier emergency telephone number on product packaging
Classification: Not considered hazardous under GHS criteria for most lab settings
Physical Hazards: Non-combustible solid in normal conditions
Health Hazards: Dust can irritate the eyes, skin, or respiratory tract. May cause allergic reactions in sensitive individuals after repeated exposure
Environmental Hazards: No known significant effects or critical hazards at laboratory usage levels
Label Elements: No hazard pictogram, signal word not required
Precautionary Statements: Avoid breathing dusty material, avoid contact with skin and eyes
Chemical Name: Ribonuclease A
Concentration: Typically >90% pure, depending on product specification
Impurities: Trace protein or salt contaminants depending on purification process
Molecular Weight: 13.7 kDa
Source: Bovine pancreas (unless noted recombinant source)
General Advice: Seek medical attention for any persistent symptoms
Inhalation: Move victim to fresh air, monitor for symptoms, consult medical personnel if irritation persists
Skin Contact: Wash with soap and plenty of water, remove contaminated clothing
Eye Contact: Rinse with plenty of water for 15 minutes, lift eyelids occasionally
Ingestion: Rinse mouth, seek advice from medical personnel, do not induce vomiting without medical instruction
Special Medical Attention: Allergy risk for those previously sensitized; inform medical personnel of proteinaceous nature
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Unsuitable Extinguishing Media: None noted for routine laboratory quantities
Fire Hazards: Material itself unlikely to burn; packaging or additives may fuel fire
Decomposition Products: Emits nitrogen oxides, carbon monoxide, carbon dioxide under fire conditions
Precautions: Wear self-contained breathing apparatus and protective clothing
Protection for Firefighters: Standard procedures for laboratory fires, avoid inhalation of combustion gases
Personal Precautions: Avoid dust formation, ventilate area, use standard laboratory PPE—lab coat, safety goggles, gloves
Environmental Precautions: Do not allow solution or powder to enter drains or natural water bodies
Spill Cleanup: Collect spilled material using wet methods to minimize dust, transfer to suitable container for disposal, clean area with water and detergent
Disposal of Collected Material: Dispose of as laboratory biowaste in accordance with local regulations, do not reuse containers
Handling: Avoid generating and breathing dust, avoid contact with skin and eyes, handle in well-ventilated conditions
Storage Conditions: Store lyophilized product at +2°C to +8°C or in accordance with supplier label; keep tightly closed
Storage Incompatibilities: Store away from food, drink, strong oxidizers, acids or bases
Other Recommendations: Label all containers clearly, restrict access to trained personnel, check expiry dates
Exposure Limits: No occupational exposure limits established for this protein
Engineering Controls: Use local exhaust ventilation or fume hood for large or repeated operations
Personal Protection: Wear laboratory gloves, protective eyewear, lab coat or gown
Respiratory Protection: Use dust mask if routine airborne exposure likely or in poorly ventilated areas
Hygiene Measures: Wash hands after handling; remove contaminated clothing before leaving the lab
Appearance: White to off-white powder or lyophilized cake
Odor: Odorless
pH (1% solution): Approximately 5.0–7.0
Melting Point: Protein denatures above 60°C
Solubility in Water: Soluble
Partition Coefficient: Not applicable
Vapor Pressure: Not volatile
Flash Point: Not determined, non-flammable material
Other Physical Data: Stable when stored as directed; hygroscopic in open atmosphere
Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: No hazardous reactions anticipated with normal laboratory use
Incompatible Materials: Strong acids, bases, oxidizers can degrade protein
Hazardous Decomposition Products: Carbon oxides and nitrogen oxides at high temperature
Conditions to Avoid: Excess heat, moisture, exposure to light
Acute Toxicity: No accurate LD50 data available for humans; low acute toxicity expected based on protein structure
Routes of Exposure: Inhalation, skin or eye contact, ingestion
Chronic Effects: Possible sensitization causing allergic reactions in rare cases
Symptoms: Irritation to respiratory tract, skin, eyes; allergy symptoms include sneezing, rash, or asthma
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, OSHA
Mutagenicity: No evidence for mutagenic potential
Reproductive Toxicity: Not known to cause reproductive toxicity
Ecotoxicity: Protein expected to degrade in environment, low bioaccumulation potential
Mobility in Soil: Readily degraded by microbial action
Persistence and Degradability: Biodegradable under environmental conditions
Aquatic Toxicity: Unlikely to pose hazard to aquatic life at laboratory release levels
Other Adverse Effects: No information indicating significant environmental impact for laboratory disposal volumes
Disposal Methods: Treat as non-hazardous laboratory biowaste unless contaminated with other hazardous materials
Container Handling: Rinse empty containers before disposal, follow institutional protocols
Disposal Guidance: Dispose of in accordance with local, regional, and national regulations for laboratory waste
Waste Code: Not assigned; refer to local codes for protein waste disposal from laboratories
UN Number: Not regulated as a hazardous material for transport
Proper Shipping Name: Not classified as dangerous goods
Packaging Requirements: Use standard laboratory shipping containers with proper labeling
Transport Hazard Class: Not assigned
Environmental Hazards: None known in transported form
Special Precautions: Protect containers from physical damage, avoid extreme temperatures
OSHA Status: Not hazardous under OSHA workplace regulations
TSCA Status: Not listed
DSL/NDSL (Canada): Not listed
RoHS / REACH (EU): Not subject to regulation as a restricted substance
Other Regulations: Product intended for research use only, not for human or animal therapeutic use
Labeling Requirements: Observe standard laboratory reagent labeling, precautionary handling statements as good laboratory practice
