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Substance Name: Rapamycin
Synonyms: Sirolimus, AY-22989, Rapamune
Chemical Formula: C51H79NO13
CAS Number: 53123-88-9
Manufacturer: Contact supplier for detailed information
Recommended Uses: Immunosuppressive agent for research and pharmaceutical manufacturing
Emergency Contact: Local poison control and first responders
Classification: Toxic if inhaled, swallowed, or absorbed through skin. Irritant for eyes, skin, respiratory system.
Pictograms: Skull and crossbones, exclamation mark
Signal Word: Danger
Hazard Statements: Causes damage to organs through prolonged or repeated exposure. Harmful if enters environment. Sensitizer with potential for allergic reactions upon contact.
Precautionary Statements: Avoid breathing dust or aerosols. Prevent release to the environment. Use personal protective equipment.
Chemical: Rapamycin
Concentration: 98% or higher (purity varies by supplier)
Impurities: Minimal, trace solvents possible depending on manufacturing process
Other Ingredients: None added, consult batch certificate for detailed analysis
Eye Contact: Flush with running water for at least 15 minutes. Remove contact lenses. Seek immediate medical care.
Skin Contact: Wash thoroughly with soap and water for several minutes. Remove contaminated clothing. Get medical advice if irritation appears.
Inhalation: Move to fresh air, monitor respiratory function, provide oxygen if breathing becomes difficult. Call a doctor.
Ingestion: Rinse mouth. Seek urgent medical help; keep person calm and do not induce vomiting unless instructed.
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam
Unsuitable Media: Water streams may spread material
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, toxic fumes
Protective Equipment: Full protective suit with self-contained breathing apparatus for firefighters
Specific Hazards: Fine dust may form explosive mixtures with air. Keep containers cool to prevent buildup of pressure.
Personal Precautions: Evacuate unnecessary personnel, ventilate area, avoid dust formation. Use respiratory protection.
Environmental Precautions: Prevent soil, surface water, and sewage contamination.
Cleanup Methods: Collect spill carefully with damp absorbent material. Place in chemical waste container. Clean with appropriate detergent—do not flush to drain.
Handling: Work under chemical fume hood with lab coat, gloves, and appropriate mask. Wear eye protection. Limit handling to trained staff.
Storage: Store in tightly sealed original container at cold temperatures (2-8°C). Protect from light, humidity, and incompatible substances. Label storage containers clearly.
Engineering Controls: Handle in certified chemical fume hood. Maintain adequate mechanical exhaust ventilation.
Personal Protective Equipment: Use nitrile gloves, protective clothing, safety goggles, disposable mask or respirator rated for fine particulates.
Hygiene Measures: Wash hands before eating, drinking, or leaving work area. Do not reuse contaminated clothing.
Exposure Limits: No occupational exposure limits set, but minimize dust and aerosol exposure as much as possible.
Appearance: Off-white to yellow crystalline powder
Odor: Odorless or faint organic smell
Solubility: Soluble in DMSO, methanol, ethanol; practically insoluble in water
Melting Point: 183-185°C (decomposes)
Boiling Point: Not available
pH: Not applicable
Vapor Pressure: Negligible at room temperature
Partition Coefficient (Log Pow): Not reported
Flash Point: Not determined
Chemical Stability: Stable under recommended storage and use conditions
Reactive With: Strong oxidizing agents, acids, bases
Decomposition Products: Produces toxic fumes—carbon monoxide, carbon dioxide, nitrogen oxides—upon heating
Polymerization Hazard: Does not polymerize
Conditions to Avoid: Strong light, elevated temperature, moisture, contamination with incompatible chemicals
Acute Toxicity: Highly toxic in animal studies, low LD50 values observed in rodents
Routes of Exposure: Inhalation, ingestion, skin, or eye contact
Symptoms: May include headache, dry mouth, dizziness, allergic skin reactions, gastrointestinal distress, respiratory irritation
Chronic Effects: Target organ damage (primarily immune system, kidneys, liver) with prolonged exposure
Carcinogenicity: Not classified by IARC or NTP. Not listed as carcinogen in OSHA
Reproductive Toxicity: Possible hazard, avoid exposure if pregnant or planning pregnancy
Aquatic Toxicity: Highly toxic to aquatic organisms, risk of persistence and bioaccumulation
Mobility: Low mobility in soil, strong adsorption to particulate material
Persistence and Degradability: Slowly biodegradable in environment
Bioaccumulation: Potential for bioaccumulation in aquatic food chain
Other Environmental Data: Do not allow large quantities to enter waterways, risk to flora and fauna in spill events
Waste Disposal: Dispose of collected material as special chemical waste in accordance with local, national, and international regulations. Incineration under controlled conditions may be preferred.
Contaminated Packaging: Treat as hazardous waste, flush empty containers with large volumes of water before disposal.
Precautions: Do not release to environment. Record all disposal actions. Work with approved chemical disposal services.
UN Number: Not assigned specific UN code for rapamycin
Proper Shipping Name: Chemical, not otherwise specified
Transport Hazard Class: Consult transport advisor for up-to-date classification
Packaging Group: III (if regulated)
Environmental Hazards: Marine pollutant (potential, depends on quantity and concentration)
Special Precautions: Package securely, prevent leaks, accompany with shipping documentation citing all hazards
OSHA Status: Handle as hazardous due to toxicity
SARA Title III: Minimal reporting requirements for small laboratory quantities
TSCA (US): Not listed for commercial manufacture
WHMIS (Canada): Not assigned specific class
REACH (EU): Registrant must consult current, region-specific guidance
Other Regulations: Observe occupational exposure standards, hazard communication rules, laboratory safety mandates
