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Product Name: Quinine Hydrochloride Dihydrate
Chemical Formula: C20H24Cl2N2O2·2H2O
CAS Number: 6119-70-6
Molecular Weight: 414.35 g/mol
Product Use: Antimalarial, Pharmaceutical intermediate
Synonyms: Quinine dihydrochloride hydrate, 6'-methoxycinchonan-9-ol dihydrochloride dihydrate
Manufacturer: Contact supplied on procurement
Emergency Number: Poison control or local emergency services
Recommended Restrictions: Research, pharmaceutical manufacturing, laboratory settings only
Classification: Acute Toxicity (Oral, Dermal, Inhalation); Eye Irritation; Reproductive Toxicity
Label Elements: Signal Word: Danger, Pictograms: Skull and crossbones, Exclamation mark, Health hazard
Hazard Statements: Toxic if swallowed, Causes serious eye irritation, Suspected of harming the unborn child, Harmful in contact with skin or if inhaled
Precautionary Statements: Do not eat, drink, or smoke when using; Wash hands thoroughly after handling; Avoid release to the environment
Other Hazards: Exposure may affect heart rhythm; Possible respiratory distress in sensitive individuals
Chemical Name: Quinine Hydrochloride Dihydrate
Concentration: 98-100%
CAS Number: 6119-70-6
Impurities: Typically contains trace water content and low-level organic impurities from synthesis; proportion below reporting threshold
Other Components: No hazardous stabilizers or additives
Ingredient Disclosure: Product does not intentionally include known human carcinogens above 0.1%
Inhalation: Remove person to fresh air, provide artificial respiration if breathing has stopped; seek medical attention for persistent symptoms like coughing or chest pain
Skin Contact: Wash with plenty of running water and non-abrasive soap; remove contaminated clothing and wash before reuse; if irritation persists consult a doctor
Eye Contact: Rinse cautiously with water for at least 15 minutes, holding eyelids open; seek ophthalmological advice immediately if discomfort continues
Ingestion: Rinse mouth with water, avoid inducing vomiting unless directed by medical staff; get prompt medical assistance due to toxicity
Note for Physicians: Cardiac monitoring recommended, supportive management for hypersensitivity or arrhythmias
Suitable extinguishing media: Use water spray, dry chemical, CO2, or foam extinguishers
Specific hazards: Potential release of irritating and toxic fumes such as hydrochloric acid, nitrogen oxides, and carbon oxides during fire
Protective equipment: Firefighters require self-contained breathing apparatus and suitable chemical-resistant clothing
Special procedures: Contain runoff to prevent environmental contamination; cool exposed containers to reduce pressure risks
Explosion data: No known explosive properties, but fine particles may create dust clouds
Personal precautions: Use personal protective equipment including gloves, goggles, and lab coats; avoid inhaling dust or contact with skin
Environmental precautions: Prevent entry to drains, waterways, or soil; notify relevant authorities if significant spillage occurs
Spill response: Collect solid product with a vacuum equipped with HEPA filter or sweep up while minimizing dust; place in closable, labeled containers
Cleaning procedure: Wash contaminated area thoroughly with water and detergent; ventilate area well after cleanup
Handling: Maintain good laboratory hygiene, minimize airborne dust through local exhaust or fume hood, avoid direct skin or eye contact, use only in well-ventilated settings
Storage: Store in tightly closed containers, away from strong light, heat sources, and incompatible chemicals such as strong oxidants and acids; recommended temperature is below 25°C in a dry, secure area
Special considerations: Keep separate from foodstuff and out of reach of children; use secondary containment for large stock quantities
Exposure limits: No established OSHA or ACGIH limits for quinine hydrochloride; handle as a hazardous pharmaceutical compound requiring low-exposure thresholds
Engineering controls: Operate in a chemical fume hood with efficient local exhaust; use safety showers and eyewash stations nearby
Personal protective equipment: Nitrile gloves, safety goggles, long-sleeved laboratory coats, and, where risks of inhalation exist, NIOSH-approved respirators
Hygienic practices: Wash hands before breaks and after handling; do not eat, drink, or smoke while using this material
Appearance: White or faintly yellow crystalline powder
Odor: Odorless or slightly bitter odor
Odor threshold: Data not available
pH (1% solution): Approximately 3.5 – 4.5
Melting point: 250°C (decomposes)
Solubility: Freely soluble in water, sparingly soluble in alcohol
Boiling point: Not applicable (decomposes before boiling)
Vapor pressure: Not significant at room temperature
Density: Approx. 1.35 g/cm3
Flash point: Not flammable
Partition coefficient: logP = 2.1 (for quinine base)
Other properties: Stable under ambient conditions if unopened and moisture-proof
Chemical stability: Stable under recommended handling and storage, sensitive to extended exposure to light and moisture
Reactivity: Non-reactive under normal conditions, avoid strong oxidizers, acids, and alkalies
Hazardous reactions: No dangerous polymerization expected
Hazardous decomposition: Produces hydrochloric acid, nitrogen oxides, and carbon oxides during thermal breakdown or combustion
Incompatible materials: Strong acids, bases, oxidizing agents
Acute toxicity: Oral LD50 (rat) approx. 400 mg/kg
Symptoms of exposure: Headache, blurred vision, nausea, cardiac arrhythmia, hearing loss (cinchonism), confusion; severe cases—kidney or liver impairment
Chronic effects: Prolonged exposure may result in sensory neural damage, cardiac and muscular complications
Carcinogenicity: Not officially classified as carcinogenic by IARC, NTP, or OSHA
Reproductive toxicity: Animal studies suggest potential embryotoxicity at higher exposures
Other data: Allergic reactions possible in sensitive individuals; medical supervision advised for underlying heart conditions
Ecotoxicity: Harmful to aquatic organisms, risk of long-term effects in aquatic environments
Persistence and degradability: Not rapidly biodegradable; can persist in water and soil for extended periods
Bioaccumulation: Potential to accumulate in aquatic species with chronic exposure
Mobility in soil: Moderately mobile, solubility in water can lead to plant uptake
Other ecological notes: Limit all unnecessary environmental release, follow local regulations for disposal and remediation
Waste treatment: Treat as hazardous chemical waste according to regional, national, and local regulations
Contaminated packaging: Container residues should be triple-rinsed, then neutralized or incinerated; dispose through licensed waste management provider
Prevention: Avoid release to sewer, surface water, or soil
Disposal methods: Incineration recommended for complete destruction; landfilling not preferred unless allowed by regulatory authorities
UN Number: Not regulated under UN transport regulations
Transport hazard class: Not classified as a dangerous good for transport by ADR/RID, IMDG, IATA
Packing group: Not applicable
Proper shipping name: Quinine Hydrochloride Dihydrate
Special precautions: Protect package from direct sunlight, moisture, and physical damage during transport; ship in tightly sealed containers
Inventory status: Listed on relevant chemical inventories such as TSCA (US), EINECS (EU), DSL (Canada)
Labelling: Complies with hazard communication standards as outlined by OSHA, EU CLP, and GHS
SARA Title III: Not listed as an extremely hazardous substance
California Proposition 65: Not known to contain listed substances
Other regulatory notes: Controlled substance status varies by country, prescription and permit requirements may apply for use
