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Product Name: 1-Methyl-2-pyrrolidinone
Synonyms: N-Methyl-2-pyrrolidone, NMP
Chemical Formula: C5H9NO
CAS Number: 872-50-4
Recommended Use: Industry solvent for polymers, electronics, pharmaceuticals
Manufacturer Contact: Available through industry-specific suppliers and manufacturers
Emergency Phone: Local emergency or poison control centers advise on immediate dangers
GHS Classification: Eye Irritation Category 2, Reproductive Toxicity Category 1B, Skin Irritation Category 2
Signal Word: Danger
Hazard Statements: Causes serious eye irritation, suspected of damaging fertility or the unborn child, causes skin irritation
Precautionary Statements: Wear gloves, eye protection, avoid release to environment, wash thoroughly after handling
Pictograms: Exclamation mark, health hazard
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Target Organs: Eyes, skin, reproductive system
Chemical Name: 1-Methyl-2-pyrrolidinone
Concentration: Greater than 99% pure
Other Components: Contains trace impurities, nonhazardous byproducts
CAS Number: 872-50-4
EC Number: 212-828-1
Inhalation: Move person to fresh air right away, seek medical care if symptoms such as coughing or dizziness occur
Skin Contact: Remove contaminated clothing, wash skin with large amounts of soap and water, seek attention if reddening or irritation persists
Eye Contact: Rinse immediately with water for at least 15 minutes, hold eyelids apart, go to doctor if irritation continues
Ingestion: Do not induce vomiting, rinse mouth, get medical advice immediately, never give anything by mouth to an unconscious person
Symptoms: Red eyes, dry or cracked skin, respiratory discomfort, nausea in severe cases
Extinguishing Media: Use dry chemical, foam, CO2, or water spray; avoid high-pressure water streams
Specific Hazards: Can emit toxic fumes such as nitrogen oxides and carbon monoxide on combustion
Protective Equipment: Firefighters use full protective gear and self-contained breathing apparatus
Firefighting Tips: Keep cool by spraying with water, keep run-off water contained to prevent soil contamination
Personal Precautions: Evacuate area if volume is large, ventilate closed spaces, use personal protection equipment
Environmental Precautions: Block spillage from entering waterways, drains, or soil
Clean Up Methods: Absorb with inert material such as dry sand or earth, keep in containers for safe disposal
Decontamination: Wash spill site after material pickup, ensure area is safe before allowing entry
Handling: Avoid contact with skin, eyes and clothing, use only in well-ventilated areas, keep containers closed when not in use
Storage Conditions: Store in cool, well-ventilated place, keep away from heat or open flame, keep container tightly sealed
Incompatible Materials: Strong oxidizing agents, acids, alkalis
Advice on General Occupational Hygiene: No eating, drinking or smoking in areas where chemical is handled; wash hands before breaks and after handling
Engineering Controls: Use local exhaust ventilation or other engineering controls to limit airborne exposure
Exposure Limit Values: ACGIH TLV: 10 ppm skin, OSHA: Not established; always use lowest practical level
Personal Protection: Chemical safety goggles, gloves resistant to chemicals (nitrile recommended), apron or protective clothing
Respiratory Protection: Wear appropriate protective mask if ventilation is inadequate
Hygiene Measures: Regularly wash hands, clean equipment and work areas after use
Appearance: Colorless to pale yellow liquid
Odor: Mild, ammonia-like
Odor Threshold: Not easily noticeable below hazardous levels
pH (10g/L solution): 8-10
Melting Point: -24°C
Boiling Point: 202°C
Flash Point: 91°C closed cup
Evaporation Rate: Slower than ether
Flammability: Not easily ignited under standard conditions
Vapor Pressure: <1 mmHg at 20°C
Relative Density: 1.03
Water Solubility: Fully mixable in water
Partition Coefficient (Log Kow): -0.54
Viscosity: About 1.67 mPa·s at 25°C
Auto-ignition Temperature: 245°C
Chemical Stability: Stable under recommended handling and storage conditions
Hazardous Reactions: Can react with strong oxidizers, acids, alkalis to produce heat or hazardous gases
Decomposition Products: Yields carbon oxides, nitrogen oxides on burning or decomposition
Conditions to Avoid: High temperatures, open flames, incompatible chemical combinations
Acute Toxicity (oral, rat): LD50 = 3914 mg/kg
Skin Irritation: May cause irritation with prolonged or repeated contact
Eye Damage/Irritation: Definite risk of eye irritation with direct splashes
Respiratory or Skin Sensitization: Not recognized as a sensitizer
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Mutagenicity: Studies show negative results for gene mutation
Reproductive Toxicity: Evidence of impact on unborn children or fertility from animal studies
Symptom Information: Headache, dizziness, confusion, nausea after exposure
Aquatic Toxicity: Low to moderate hazard for aquatic life based on LC50 levels (fish, daphnia, algae)
Persistence and Degradability: Readily biodegradable in environment
Bioaccumulative Potential: Low accumulation in organisms (low Log Kow)
Mobility in Soil: Highly mobile due to solubility in water
Other Adverse Effects: May cause foaming or pollution in high-volume accidental releases
Waste Treatment Methods: Collect waste for chemical disposal according to local environmental and hazardous waste regulations
Disposal of Containers: Empty containers left with residue treated as hazardous waste
Special Precautions: Never dispose of in regular garbage or via drains, seek out approved chemical waste agents
UN Number: Typically not regulated as hazardous cargo for road, air, rail, sea
DOT Classification: Non-regulated
IMDG/IATA: Review current transport code guidelines, as classification can vary by amount and packaging
Special Transport Precautions: Secure containers tightly, maintain upright position, avoid rough handling to prevent leaks
OSHA Hazcom: Hazardous under OSHA Hazard Communication Standard
TSCA (US): Listed on Toxic Substances Control Act inventory
REACH (EU): Registered under EC regulations, subject to restrictions related to reproductive toxicity
SARA Title III: Not subject to Section 313 reporting
DSL (Canada): Present on Domestic Substances List
Labeling Requirements: GHS pictograms, hazard, and precautionary statements on packaging, safety data sheets available for users
