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Product Name: Pyrene
Chemical Formula: C16H10
CAS Number: 129-00-0
Synonyms: Benzo[def]phenanthrene
Recommended Use: Laboratory chemicals, synthesis, research uses
Manufacturer Information: Refer to supplier’s contact details
Emergency Contact: Local poison control center, company emergency number, or national chemical emergency center
Classification: Acute toxicity (oral), Category 4; Skin irritation, Category 2; Eye irritation, Category 2A; Carcinogenicity, Category 2
Signal Word: Warning
Hazard Statements: Harmful if swallowed, causes skin and eye irritation, suspected of causing cancer
Pictograms: Exclamation mark, health hazard
Precautionary Statements: Do not breathe dust or vapor, wear protective gloves and eye/face protection, wash thoroughly after handling, avoid release into the environment
Potential Routes of Exposure: Inhalation, skin contact, ingestion, eye contact
Chemical Name: Pyrene
Concentration: ≥ 99%
Common Impurities: Minor amounts of other polycyclic aromatic hydrocarbons
Additives: None reported
Inhalation: Move person to fresh air, maintain breathing with artificial respiration if necessary, seek medical attention if symptoms persist
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, consult a doctor if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, seek medical help if irritation persists
Ingestion: Do not induce vomiting, rinse mouth, never give anything by mouth to a person who is unconscious, call emergency medical services promptly
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray
Specific Hazards Arising from Substance: Emits toxic fumes of carbon monoxide and carbon dioxide under fire conditions
Protective Equipment: Firefighters require self-contained breathing apparatus and full protective gear
Firefighting Instructions: Contain runoff to prevent entry into water systems, approach the fire from upwind to avoid hazardous vapors
Personal Precautions: Wear respirator, protective gloves, and chemical safety goggles
Environmental Precautions: Prevent product from entering drains and waterways, avoid soil and ground water contamination, notify environmental agencies if release is significant
Methods for Clean-Up: Collect spills using non-sparking tools, absorb with inert material such as sand, transfer to labeled containers for disposal, ventilate area thoroughly
Handling: Handle in a chemical fume hood, avoid dust formation, minimize exposure through use of protective clothing and proper hygiene practices, avoid ingestion, inhalation, and contact with eyes or skin
Storage Conditions: Store in tightly closed containers, keep in a cool, dry, well-ventilated area away from incompatible materials such as oxidizing agents, isolate from heat or sources of ignition
Incompatibilities: Strong oxidizers, nitric acid, peroxides
Exposure Limit Values: OSHA, ACGIH, and NIOSH have not established occupational exposure limits for pyrene specifically, but general nuisance dust limits may apply
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to minimize airborne exposure
Personal Protective Equipment: Safety goggles, chemically resistant gloves, long-sleeved clothing, boots, and approved respirator for dust or vapor
Hygiene Measures: Do not eat, drink, or smoke while working with pyrene, wash hands and exposed areas after use
Appearance: Pale yellow crystalline powder
Odor: Mild aromatic odor
Melting Point: 151-156°C
Boiling Point: 393°C
Flash Point: 221°C (closed cup)
Solubility: Practically insoluble in water, soluble in organic solvents such as benzene, chloroform
Vapor Pressure: Very low at room temperature
Relative Density: 1.25 at 20°C
Partition Coefficient (log Kow): 4.88
pH: Not applicable
Chemical Stability: Stable under recommended storage conditions and normal temperature ranges
Reactivity: Unreactive in most handling situations
Hazardous Reactions: May react with strong oxidizing agents, nitric acid, and peroxides producing hazardous decomposition products
Decomposition Products: Produces carbon monoxide, carbon dioxide, and possibly acrid smoke and other toxic fumes under high temperatures or in a fire
Conditions to Avoid: Excessive heat, open flames, and incompatibles
Possible Routes of Exposure: Eyes, skin, inhalation, ingestion
Short-Term Exposure Effects: Causes irritation to eyes, skin, and respiratory tract, gastrointestinal discomfort if swallowed
Long-Term Exposure Effects: May cause liver and kidney damage, potential carcinogen as some polycyclic aromatic hydrocarbons are, reproductive toxicity not fully established
Acute Toxicity (Oral): LD50 (rat): > 894 mg/kg
Chronic Toxicity: Evidence of carcinogenicity in animal studies, classified as possibly carcinogenic to humans by IARC (Group 3)
Sensitization: Not classified as a sensitizer
Mutagenicity: Evidence for mutagenic effects in some studies
Reproductive Toxicity: Insufficient data for assessment
Environmental Fate: Persistent in the environment, poorly soluble in water, high potential for bioaccumulation in aquatic organisms
Aquatic Toxicity: Toxic to aquatic life with long lasting effects, LC50 (fish, 96h): 0.6 mg/L (fathead minnow)
Soil Mobility: Adsorbs strongly to soils and sediments, slow degradation
Potential to Bioaccumulate: High, based on log Kow and bioconcentration data
Degradation: Photodegradable under sunlight given long exposure, limited in dark environments
Other Effects: Can have chronic effects on aquatic organisms even at low concentrations
Waste Treatment Methods: Incinerate in a chemical incinerator equipped with afterburner and scrubber, dispose of in compliance with local and national regulations
Container Handling: Contaminated packaging treated as hazardous waste, triple rinse and dispose of according to approved pollution control standards
Sewage Disposal: Do not allow material or wash water to reach drains or natural water sources
RCRA Code: Not specifically listed, consult local waste disposal authority for classification
Waste Classification: Hazardous due to toxicity and carcinogenic potential
UN Number: 3077
Proper Shipping Name: Environmentally hazardous substance, solid, n.o.s. (Pyrene)
Transport Hazard Class: 9 (Miscellaneous Dangerous Substances and Articles)
Packing Group: III (low danger)
Labels Required: Miscellaneous hazard, Environmentally Hazardous
Marine Pollutant: Yes
Special Precautions: Avoid transportation with food or feed items, carry in tightly sealed containers, follow applicable regional and international transport guidelines
DOT, IATA, IMDG Status: Regulated for shipment
SARA Title III (Section 313): Listed as a toxic chemical
TSCA Inventory: Listed
OSHA Status: Considered hazardous
California Proposition 65: Not individually listed but polycyclic aromatic hydrocarbons as a class are on the list
IARC: Group 3, not classifiable as to its carcinogenicity to humans
REACH Status (EU): Registered
WHMIS (Canada): D2A (Very toxic - carcinogenicity), D2B (Toxic - skin/eye irritant)
Other Notes: Workplace exposure and environmental limits may vary by country; consult local regulations and authorities before import, use, or disposal
