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Product Name: Puromycin Dihydrochloride
Chemical Name: Puromycin dihydrochloride
Synonyms: None commonly used
CAS Number: 58-58-2
Recommended Use: Laboratory reagent, research use only
Supplier Details: Available from multiple research chemical providers
Emergency Contact Number: Refer to local regulations and facility protocols for chemical emergencies
Major Hazards: Toxic if swallowed, causes irritation to eyes, mucous membranes, and skin
Globally Harmonized System Classification: Acute Toxicity Oral, Category 3; Eye Irritation, Category 2A; Skin Sensitization, Category 1
Signal Word: Danger
Hazard Statements: Harmful if swallowed, may cause allergic skin reaction, serious eye irritation
Pictograms: Skull and crossbones, exclamation mark
Precautionary Statements: Avoid breathing dust, wear protective gloves and eye/face protection, wash hands thoroughly after handling, do not eat, drink, or smoke during use
Chemical Identity: Puromycin dihydrochloride
Component: Puromycin dihydrochloride
Concentration: Typically ≥98% purity
Chemical Formula: C22H29N7O5·2HCl
Molecular Weight: 544.41 g/mol
Inhalation: Move person to fresh air, seek medical attention for any symptoms
Skin Contact: Remove contaminated clothing, wash skin gently with plenty of soap and water, consult medical personnel for irritation
Eye Contact: Immediately rinse with water for no less than 15 minutes, keep eyelids open, seek medical assistance if irritation persists
Ingestion: Rinse mouth with water, do not induce vomiting, obtain medical advice immediately
Most Important Symptoms: Burning or irritation of exposed tissues, allergic reactions in susceptible individuals
Extinguishing Media: Use dry chemical, carbon dioxide, or water spray, foam can also be applied for larger fires
Hazards from Combustion: May emit toxic fumes of hydrochloric acid, nitrogen oxides, and carbon oxides
Protective Equipment: Firefighters should wear full protective clothing including self-contained breathing apparatus and chemical-resistant gloves
Special Procedures: Avoid inhalation of dust or fumes, control run-off water to prevent environmental contamination, keep unnecessary personnel from area
Personal Precautions: Wear appropriate protective clothing, gloves, and safety goggles, avoid creating dust
Environmental Precautions: Prevent product from entering drains, surface water, or soil
Methods for Clean-up: Sweep up material carefully, avoid generating dust, place into a suitable waste container for disposal, clean spills thoroughly with detergent and water, ventilate the area
Safe Handling: Keep away from food and drink, wash thoroughly after handling, avoid direct contact with the substance, use in well-ventilated areas or within fume hoods
Safe Storage: Store in tightly closed containers, in a dry and cool area, protect from light, separate from incompatible chemicals such as strong oxidizers, acids, and bases, label storage clearly
Occupational Exposure Limits: Not established, minimize exposure using good laboratory practices
Engineering Controls: Work within chemical fume hoods if dust may be generated, ensure adequate ventilation
Personal Protective Equipment: Gloves (nitrile recommended), safety goggles or glasses with side shields, lab coat, minimize direct and prolonged skin contact
Respiratory Protection: Use NIOSH-approved respirator for dust if ventilation is inadequate
Hygiene Measures: Do not eat, drink, or smoke in laboratory, wash hands before breaks and after finishing work
Appearance: White to off-white powder
Odor: None detectable
Odor Threshold: Not applicable
pH (1% solution): 2-3
Melting Point: Decomposition occurs before melting
Boiling Point: Not applicable
Solubility: Freely soluble in water
Vapor Pressure: Not applicable
Relative Density: ~1.7 g/cm³
Partition Coefficient: Not determined
Flash Point: Not determined
Autoignition Temperature: Not available
Evaporation Rate: Not available
Chemical Stability: Stable under recommended storage conditions
Reactivity: Non-reactive with common materials under standard conditions
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: Hydrochloric acid, nitrogen oxides, carbon monoxide, carbon dioxide
Conditions to Avoid: High temperature, humidity, exposure to light, and contact with incompatible chemicals
Acute Toxicity: Toxic if swallowed, toxicological profile based on published animal model data shows LD50 (oral, rat): ~70 mg/kg
Skin and Eye Contact: Causes redness, irritation, possible allergic responses
Ingestion Effects: Nausea, vomiting, abdominal pain, risk of systemic health effects
Sensitization: Sensitizing to skin for susceptible individuals
Long-Term Effects: Chronic exposure can damage organs, especially if mishandled
Carcinogenicity, Mutagenicity, Reproductive Toxicity: Not classified as carcinogen or mutagen, insufficient data for reproductive effects
Ecotoxicity: Harmful to aquatic organisms, potential to disrupt aquatic environments
Persistence and Degradability: Information indicates resistance to rapid biodegradation
Bioaccumulative Potential: Low due to water solubility, not likely to accumulate in the environment
Mobility in Soil: Expected to disperse in water and migrate in soil
Other Adverse Effects: Release to environment should be minimized, avoid contaminating surface waters or sewage
Product Disposal: Dispose as hazardous chemical waste, follow institutional, local, and national hazardous waste guidelines
Packaging Disposal: Empty containers should be rinsed, disposed of as laboratory waste, do not reuse packaging
Special Precautions: Incineration in specialized, licensed facility recommended; do not discharge to environment
Waste Code: Check regional regulations for correct waste code assignment
UN Number: Not regulated for transport by ground, air, or sea under common regulations
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Proper Shipping Name: Research chemical, non-hazardous for shipping
Special Provisions: Transport in compliance with institutional and governmental regulations, protect packaging during transit
US Regulations (OSHA, TSCA, SARA): Not listed as hazardous chemical by OSHA, not listed on TSCA inventory, not subject to SARA reporting
European Union (REACH): Exempt as a research chemical for laboratory use
Other International Regulations: Not specifically regulated in Canada, Australia, or Japan for research use
Label Elements: Signal Word: Danger; Hazard Statements and Precautionary Measures consistent with GHS
Restrictions: Use restricted to qualified personnel in controlled workplace settings
