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Product Name: Proteinase K
Chemical Name: Proteinase K from Tritirachium album
Synonyms: Endopeptidase K
CAS Number: 39450-01-6
Recommended Use: Laboratory reagent
Supplier: Refer to local distributor or manufacturer information on package
Emergency Telephone: Available on supplier safety sheet or institutional safety office
Classification: Respiratory sensitizer (Category 1), Serious eye irritation (Category 2), Skin irritation (Category 2)
Label Elements: Warning symbols for respiratory and skin hazards
Signal Word: Warning
Hazard Statements: May cause allergy or asthma symptoms, causes skin and eye irritation, may cause respiratory irritation
Precautionary Statements: Avoid breathing dust, use only outdoors or in a well-ventilated area, wear protective gloves/eye protection/face protection, wash hands thoroughly after handling
Route of Exposure: Inhalation, skin contact, eye contact
Other Hazards: Allergen, respiratory sensitizer for individuals with compromised immune systems or allergies
Substance: Proteinase K
Chemical Formula: Not applicable (protein mixture)
Concentration: >90% (by weight in pure form)
Impurities: May contain stabilizers or buffers, consult individual product batch sheets
Additional Notes: No hazardous impurities reported above safety limits
Inhalation: Move person to fresh air, seek medical attention for coughing or difficulty breathing
Skin Contact: Wash immediately with soap and water for at least 15 minutes, remove contaminated clothing
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if possible, seek medical evaluation for discomfort
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical advice if feeling unwell
Advice to Doctors: Treat symptoms with supportive care, monitor respiratory function
Suitable Extinguishing Media: Water spray, dry chemical powder, carbon dioxide, foam
Unsuitable Extinguishing Media: None known based on current test results
Specific Hazards: Protein powders can form explosive dust clouds in air, combustion may release toxic fumes (carbon oxides, nitrogen oxides)
Protection for Firefighters: Wear full protective suit, including self-contained breathing apparatus
Additional Information: Containers may burst in heat, cool fire-exposed containers with water spray
Personal Precautions: Wear respiratory protection, gloves, and eye protection
Environmental Precautions: Prevent product from entering drains, surface and ground water
Methods for Clean-up: Avoid dust formation, collect spilled powder using wet methods or vacuum with HEPA filter, ventilate area, rinse area with water after collection, dispose in accordance with local regulations
Handling: Avoid contact with skin and eyes, avoid inhalation of dust, handle in well-ventilated areas or fume hood, keep containers tightly closed
Storage Conditions: Store in sealed containers at -20°C for long-term stability, avoid humidity, separable from food and drink, store away from incompatible substances (oxidizers, acids)
Hygiene Practices: Wash hands thoroughly after handling, do not eat, drink or smoke while handling product
Control Parameters: No occupational exposure limit set for Proteinase K; minimize exposure
Engineering Controls: Work under fume hood or use local exhaust ventilation, keep containers closed
Personal Protective Equipment: Safety goggles or face shield, lab coat or chemical resistant apron, suitable gloves (nitrile or latex), N95 or higher respiratory mask if airborne exposure risk exists
Individual Protection Measures: Remove contaminated clothing, wash exposed skin, monitor for allergic reactions in sensitive individuals
Appearance: White to off-white powder or lyophilized cake
Odor: Faint, characteristic protein smell
Odor Threshold: Not established
pH: 7.5 – 12.0 (in buffer solution)
Melting/Freezing Point: Not applicable (denatures, not melts)
Boiling Point: Not applicable
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Possible dust explosion in dry form
Vapor Pressure: Not relevant for protein powders
Vapor Density: Not relevant
Solubility: Soluble in water and aqueous buffers
Partition Coefficient (n-octanol/water): Not established
Decomposition Temperature: Denatures above 70°C
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Incompatible Materials: Strong oxidizing agents, strong acids
Conditions to Avoid: Moisture, heat, sources of ignition, exposure to air for long periods
Hazardous Decomposition Products: May release carbon oxides, nitrogen oxides, sulfur compounds under fire
Polymerization: No hazardous polymerization
Acute Toxicity: Low oral and dermal toxicity based on animal studies, may cause irritation; inhalation of dust may provoke allergic response in sensitive individuals
Chronic Effects: Repeated exposure may lead to sensitization, asthma-like symptoms
Routes of Entry: Inhalation, skin, and eyes
Symptoms: Irritation to eyes, skin, respiratory tract; allergic reactions include coughing, wheezing, rashes
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Mutagenicity: No evidence of mutagenic properties in standard tests
Reproductive Toxicity: Not demonstrated in available studies
Ecotoxicity: No data for direct environmental toxicity, proteins degrade naturally
Persistence and Degradability: Degrades by enzymatic and microbial action, not persistent
Bioaccumulative Potential: Does not bioaccumulate
Mobility in Soil: Mobile in water, binds to soil
PBT/vPvB Assessment: Not identified as persistent, bioaccumulative, or toxic
Disposal Methods: Collect and send for disposal via licensed hazardous waste contractor, incinerate or landfill according to local guidelines, do not allow product to enter natural water sources
Contaminated Packaging: Dispose of in compliance with local regulations, decontaminate or incinerate if possible
Additional Precautions: Avoid dispersal of dust; keep materials contained during collection
UN Number: Not regulated as dangerous good under international transport codes (IATA, IMDG, DOT)
UN Proper Shipping Name: None assigned
Transport Hazard Class: Not hazardous
Packing Group: None
Environmental Hazards: None identified
Special Precautions: Keep containers sealed, protect from moisture in transit, avoid rupture or leakage
OSHA: No specific regulation for Proteinase K; handle as potentially hazardous dust
TSCA: Listed on US Toxic Substances Control Act registry
REACH: Exempt as biologically derived substance, not classified as hazardous for supply
SARA Title III: Not listed under Sections 302, 304, 313
IARC/NTP/OSHA Status: Not listed as carcinogen
WHMIS: Respiratory sensitizer
Other Regulations: Refer to local laboratory safety policies for handling biological enzymes
