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Product: Poly-L-Lysine Hydrobromide
Synonyms: Polylysine hydrobromide, Poly(L-lysine) hydrobromide
Chemical Formula: (C6H12N2O·HBr)n
Appearance: White to off-white powder
Common Uses: Cell culture coating, biomaterials research
CAS Number: 25988-63-0
Hazard Classification: Not classified as hazardous under GHS for most laboratory applications
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Potential Acute Effects: May cause irritation in eyes, on skin, and through inhalation
Health Risk: Repeated exposure can be harmful to the respiratory tract and mucous membranes, but no strong evidence shows carcinogenicity or reproductive toxicity
Environmental Risk: Likely low environmental hazard because of high solubility and biodegradability, though large spills deserve careful attention
Main Component: Poly-L-Lysine Hydrobromide
Purity: Over 90% in most research-grade samples
Impurities: Small amounts of water, trace salts, possible polymer chain-length variation
Molecular Weight: Varies depending on manufacturer’s specified polymerization degree, can range between 15,000 to 300,000 Daltons
Inhalation: Move to fresh air, support breathing as needed, seek medical guidance for persistent discomfort
Skin Contact: Wash skin thoroughly with soap and water, remove any contaminated clothing
Eye Contact: Rinse cautiously with water for several minutes, avoid rubbing, seek medical advice for ongoing irritation
Ingestion: Rinse mouth, drink water if conscious, do not induce vomiting unless instructed by a clinician
Medical Advice: Show medical staff this material profile if seeking treatment
Flammability: Not highly flammable, but can burn and create fumes
Extinguishing Media: Use water spray, carbon dioxide, dry chemical, or foam
Fire Hazards: Decomposition can release nitrogen oxides, hydrogen bromide, and carbon oxides
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective clothing in confined spaces
Spill Response: Stop spread using absorbent material, scoop up, and transfer residue to appropriate waste container
Personal Protection: Wear gloves, goggles, and laboratory coat
Environmental Precautions: Avoid discharge to open water or drainage, use damp cleaning methods to avoid dust
Disposal: Dispose in line with regional laboratory waste guidelines
Handling: Keep away from food areas, minimize dust creation, use only in well-ventilated spaces
Storage Temperature: Store at 2-8°C in a tightly sealed container
Compatibility: Store away from strong oxidizers and reactive chemicals
Best Practices: Label containers clearly, restrict lab access to trained personnel, and avoid eating, drinking, or smoking around the product
Exposure Limits: No regulatory exposure limits established for this material
Engineering Controls: Use with laboratory fume hood, maintain good general area ventilation
Personal Protective Equipment: Gloves made of nitrile or latex, chemical safety goggles, long-sleeved laboratory coat
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing and wash before reuse
Physical State: Solid powder
Color: White to pale yellow
Odor: Odorless
Solubility: Readily soluble in water
pH: Slightly basic in water solution
Melting Point: Decomposes at elevated temperatures rather than melting
Vapor Pressure: Not volatile at room temperature
Chemical Stability: Stable under standard laboratory conditions, sensitive to strong oxidizers
Reactivity: Reacts vigorously with strong acids, oxidizers, or bases
Thermal Decomposition: Yields hazardous gases such as hydrogen bromide and nitrogen oxides
Polymerization: Product is already polymeric, further polymerization is not an expected hazard
Acute Toxicity: Data in rodents show low oral and dermal toxicity at normal laboratory exposure
Chronic Exposure: No chronic toxicity data widely available, but polymeric nature reduces bioavailability
Irritation: Can cause mild skin and eye irritation on contact
Sensitization: Rare cases of allergic skin responses reported, but not typical
Carcinogenicity: Not listed as a carcinogen by IARC, NTP, or OSHA
Biodegradability: Poly-L-Lysine breaks down in soil and water through microbial action
Bioaccumulation: Evidence does not suggest significant bioaccumulation
Aquatic Toxicity: No data indicating high risk to aquatic life, though disposal into waterways should be avoided
Persistence: Degrades within weeks to months in active environments
Laboratory Disposal: Collect in sealed bags or bins for chemical waste removal
Regulatory Compliance: Follow local, state, and national guidelines for disposal of laboratory chemicals
Environmental Protection: Never flush large quantities down drains, incinerate or land-dispose per local regulations
UN Number/Classification: Not regulated as a dangerous good
Shipping Guidelines: Transport in tightly closed containers, outside of food items and direct sunlight
Labelling: Ensure outer packaging is labeled correctly with chemical name and hazard warnings
GHS Status: Does not fall under tightly controlled products in most regions
US Regulations: Not listed under SARA Title III, TSCA inventory includes it for laboratory use
EU Regulations: REACH-exempt for research purposes below specific volumes
Worker Safety: General chemical hygiene is enough for this product in research environments
