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Product Name: Agente de Superficie Pluronic F 127
Chemical Family: Polyethoxylated polyoxypropylene block copolymer
Synonyms: Poloxamer 407, Pluronic F127, Nonionic surfactant
CAS Number: 9003-11-6
Supplier Details: Manufacturer’s address, contact phone numbers, and emergency phone provided on packaging and official documentation
Intended Use: Laboratory research, pharmaceutical formulation, and industrial applications, not for direct human consumption
GHS Classification: Not considered hazardous by GHS criteria
Physical Hazards: Can cause slippery surfaces when spilled, mild irritation on direct skin or eye contact in sensitive individuals
Health Hazards: Not expected to produce harmful effects under recommended handling; prolonged contact may trigger dryness or irritation
Environmental Hazards: Minimal environmental effect at small volumes, large-scale releases could affect aquatic organisms due to high oxygen demand
Precautionary Statements: Avoid generating dust, avoid inhalation or ingestion, wash hands thoroughly after handling, manage spills promptly to prevent falls
Chemical Name: Poly(ethylene oxide)-poly(propylene oxide) block copolymer
CAS Number: 9003-11-6
Concentration: ≥99% by weight
Impurities: Contains residual monomers and trace stabilizers less than 1%
Other Components: No known dangerous additives or fillers
Inhalation: Move affected person to fresh air, keep at rest, seek medical attention if symptoms persist
Skin Contact: Wash thoroughly with soap and water, remove contaminated clothing, consult a physician if irritation develops
Eye Contact: Rinse cautiously with water for at least 10 to 15 minutes, lift eyelids occasionally, seek care if discomfort remains
Ingestion: Rinse mouth, drink water to dilute, avoid inducing vomiting, get medical advice for persistent discomfort or allergic response
Most important symptoms: Minor skin or eye irritation, not expected to cause delayed health effects
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, carbon dioxide, dry chemical
Unsuitable Extinguishing Media: High volume water jet if risk of dispersal
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, traces of formaldehyde
Special Protective Equipment: Firefighters wear full protective gear and self-contained breathing apparatus
Advice for Emergency Responders: Contain runoff to prevent environmental contamination, ventilate area
Personal Precautions: Use protective clothing, avoid contact with eyes and skin, ventilate area
Environmental Precautions: Prevent further leakage or spillage, stop spread to drains, surface water, and soil
Methods for Cleaning Up: Collect dry spill with shovel or vacuum, wash site with water to remove residue, manage washwater responsibly
Reference to Other Sections: Review Exposure Controls, Personal Protection, and Disposal Considerations sections for safe handling and cleanup
Precautions for Safe Handling: Use in well-ventilated spaces, avoid generation of dust, handle with care to prevent spillage
Advice on General Occupational Hygiene: Do not eat, drink, or smoke while using product, wash hands after handling
Conditions for Safe Storage: Store in original, sealed containers, in cool, dry location, away from heat, direct sunlight, incompatible chemicals
Specific End Uses: Research, formulation for industrial or academic processes, always follow workplace procedures and guidelines
Exposure Limits: No established occupational exposure limits for Pluronic F 127
Engineering Controls: Use local exhaust ventilation if handling large quantities or generating dust, maintain good general air flow
Personal Protective Equipment: Safety glasses or goggles for eye protection, gloves (nitrile or latex), lab coat or protective clothing
Respiratory Protection: In case of insufficient ventilation, use dust mask or particulate respirator
Environmental Controls: Implement measures to avoid release into the environment, maintain controls on effluent and air vents
Appearance: White granular powder, sometimes small beads or flakes
Odor: Odorless
pH (1% in water): 6.0 to 7.5
Melting Point: 53-57°C
Boiling Point: Decomposes before boiling
Flash Point: Not applicable or not determined due to non-volatile character
Solubility: Soluble in water, forms clear to slightly hazy solution
Vapor Pressure: Negligible
Density: About 1.05 g/cm³
Viscosity: Highly variable based on concentration and temperature
Partition Coefficient (n-octanol/water): Not measured
Decomposition Temperature: Above 200°C
Other Characteristics: Swells in aqueous solutions, can increase viscosity and promote miscibility
Reactivity: Stable under normal use and storage
Chemical Stability: Product remains stable if kept dry and below decomposition temperature
Possibility of Hazardous Reactions: Not reported under regular storage or usage conditions
Conditions to Avoid: Excessive moisture, high heat, long-term direct sunlight
Incompatible Materials: Strong oxidizers, strong acids, strong bases
Hazardous Decomposition Products: Thermal decomposition can yield carbon oxides, minor organic vapors
Acute Toxicity: Not classified as toxic by oral, dermal, or inhalation routes at standard laboratory doses
Skin Corrosion/Irritation: May cause mild, transient irritation with prolonged contact
Serious Eye Damage/Irritation: Non-irritating or slightly irritating to eyes
Respiratory or Skin Sensitization: Not expected to be a sensitizer though sensitive persons need to take care
Germ Cell Mutagenicity: Not known to be mutagenic
Carcinogenicity: No evidence of cancer risk
Reproductive Toxicity: No significant data indicating risk to reproductive health
Target Organ Effects: No specific target organ effects known with correct use
Experiences with Human Exposure: Generally well tolerated, risk limited to rare allergic reactions
Ecotoxicity: Low acute toxicity expected for aquatic and terrestrial organisms due to high biodegradability, large-scale releases may temporarily affect oxygen supply in water
Persistence and Degradability: Substance is considered biodegradable, breaks down under natural conditions
Bioaccumulative Potential: Not expected to accumulate in living organisms
Mobility in Soil: Moderate mobility due to water solubility
Other Adverse Effects: Report spills; do not permit massive discharges into the environment or waterways
Waste Treatment Methods: Place unused or waste material in appropriate disposal containers, dispose via licensed chemical waste contractor
Contaminated Packaging: Rinse containers thoroughly, follow disposal protocol for plastic or fiber drums
Recycling Options: Not recommended for reuse in food, pharma, or clean-room applications due to possible contamination
Local Regulations: Follow local, regional, and national guidelines for disposal
UN Number: Not regulated as dangerous good
UN Proper Shipping Name: Not listed as hazardous material
Transport Hazard Class: None assigned
Packing Group: None
Special Precautions: Secure containers, avoid moisture ingress, prevent spillage during loading and transit
Additional Information: Product travels safely under standard shipping protocols, no temperature sensitivity below 50°C
Regulation Status: Not classified as hazardous under global chemical regulations (GHS, OSHA, EU CLP)
Inventory Status: Registered in US TSCA, listed in EINECS/ELINCS, included in other chemical inventories
Labeling Requirements: General caution for lab and industrial use, use PPE, avoid contact with sensitive organs
Workplace Controls: Employers are responsible for staff being informed about safe handling and exposure minimization
Chemical Safety Assessment: Full risk assessment performed where applicable, included in workplace documentation
Reference Documentation: Consult national legislation and workplace safety directives for updates or regional notices
