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Product Name: Piperidine
Chemical Formula: C5H11N
Molecular Weight: 85.15 g/mol
Synonyms: Azacyclohexane, Hexahydro-pyridine
CAS Number: 110-89-4
Recommended Use: Laboratory chemical, intermediate for pharmaceuticals, solvents
Supplier Details: Detailed address, emergency phone, and contact information must be visible on the actual MSDS.
Classification: Flammable liquid (Category 3), Acute toxicity oral (Category 3), Acute toxicity dermal (Category 3), Skin corrosion/irritation (Category 1B), Serious eye damage/irritation (Category 1), Specific target organ toxicity - single exposure (Category 3)
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage. Toxic if swallowed or in contact with skin. May cause respiratory irritation. Flammable liquid and vapor.
Precautionary Statements: Avoid breathing vapors. Wear protective gloves and eye protection. Keep away from heat, sparks, open flames. Use explosion-proof electric equipment. Store in a well-ventilated place. Wash hands thoroughly after handling.
Symptoms: Burning sensation, coughing, shortness of breath, pain in mouth, throat, or eyes, respiratory tract irritation.
Substance: Piperidine
Concentration: 99% or greater in most commercial sources
CAS Number: 110-89-4
Impurities: Water content typically less than 1%, trace organic residues vary by manufacturer.
Inhalation: Move person to fresh air, keep comfortable for breathing. Get immediate medical help.
Skin Contact: Remove contaminated clothing. Rinse skin with plenty of water for 15 minutes. Seek medical attention immediately.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Get medical attention.
Ingestion: Do not induce vomiting. Rinse mouth. Give plenty of water if conscious. Get medical help straight away.
Most Important Symptoms: Severe irritation, burns, breathing difficulty, possible central nervous system effects, risk of unconsciousness.
Suitable Extinguishing Media: Water spray, alcohol-resistant foam, dry chemical, carbon dioxide
Hazards: Highly flammable liquid and vapor, vapors can form explosive mixtures with air
Special Protective Equipment: Use self-contained breathing apparatus and protective gear
Specific Fire Hazards: Emits toxic fumes of nitrogen oxides and carbon oxides under combustion
Additional Advice: Cool fire-exposed containers with water spray. Approach from upwind, contain run-off to prevent environmental contamination.
Personal Precautions: Wear gloves, goggles, splash apron, suitable vapor respiratory protection. Keep ignition sources away. Evacuate area if necessary.
Environmental Precautions: Prevent spillage into waterways, drains, and soil.
Methods for Clean-Up: Absorb spill with inert material such as sand or vermiculite, place in closed container for disposal.
Further Information: Ventilate area thoroughly after clean-up. Wash contaminated surfaces with detergent and water.
Handling: Handle in chemical fume hood or well-ventilated place. Avoid breathing vapors or contact with skin and eyes. Use explosion-proof equipment.
Storage: Store tightly sealed in original container. Keep in a cool, dry, well-ventilated area away from heat sources, incompatible materials like oxidizers, acids, halogenated compounds.
Special Precautions: Empty containers retain residue and can be hazardous. Ground and bond containers during transfer.
Engineering Controls: Use chemical fume hood, mechanical exhaust, safety shower, eyewash station in immediate area.
Workplace Exposure Limits: OSHA PEL 10 ppm (35 mg/m3) (TWA); ACGIH TLV 1 ppm (3 mg/m3) (TWA)
Personal Protective Equipment: Chemical-resistant gloves (nitrile or butyl rubber), safety goggles or face shield, lab coat or impervious protective clothing, approved respiratory protection for vapor if needed.
Hygiene Measures: Wash hands, arms, and face thoroughly before eating, drinking, or smoking after handling.
Appearance: Colorless to pale yellow liquid
Odor: Fishy, ammonia-like
Boiling Point: 106°C (222.8°F)
Melting Point: -7°C (19.4°F)
Flash Point: 16°C (60.8°F)
Evaporation Rate: No data available
Flammability: Flammable
Vapor Pressure: 34 hPa (at 20°C)
Vapor Density: 2.9 (air = 1)
Solubility: Miscible in water, alcohol
pH: Alkaline
Partition Coefficient (n-octanol/water): 0.84
Density: 0.862 g/cm3 at 20°C
Auto-ignition Temperature: 340°C (644°F)
Explosive Limits: 1.7% - 13% (v/v in air)
Chemical Stability: Stable under recommended storage and handling conditions
Possible Hazardous Reactions: Reacts violently with strong oxidizers, acids, acyl chlorides, acid anhydrides
Conditions to Avoid: Heat, flames, sparks, static discharge
Incompatible Materials: Strong acids, oxidizing agents, halogenated hydrocarbons
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, and ammonia fumes may be released on burning
Routes of Exposure: Inhalation, ingestion, skin contact, eye contact
Acute Toxicity: Oral LD50 (rat): 400 mg/kg. Dermal LD50 (rabbit): 950 mg/kg. Inhalation LC50 (rat, 4h): 3.9 mg/L.
Health Effects: Inhalation: coughing, sore throat, dizziness, drowsiness, symptoms of central nervous system depression. Skin: severe burns, pain, redness. Eye: severe irritation, possible permanent damage. Ingestion: rapid onset of gastrointestinal pain, burns, vomiting, possible convulsions.
Chronic Effects: May cause liver and kidney damage after long or repeated exposure. Sensitization and allergic reactions reported in sensitive individuals.
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA.
Mutagenicity and Reproductive Toxicity: No strong evidence for mutagenic or reproductive risks based on available studies.
Ecotoxicity: Toxic to aquatic life. Fish LC50 (96h): 46 mg/L (Leuciscus idus). Invertebrates EC50 (48h): 52 mg/L (Daphnia magna).
Persistence and Degradability: Readily biodegradable in environment with half-life of several days to weeks depending on conditions.
Bioaccumulative Potential: Low, based on partition coefficient.
Mobility: High mobility in soil and water due to high solubility.
Other Adverse Effects: Can raise pH in water, potentially harming aquatic species. Avoid discharge into environment.
Waste Treatment Methods: Dispose of content and container through a licensed hazardous waste disposal contractor.
Contaminated Packaging: Remove all residues, rinse with compatible solvent, and treat rinsate as hazardous waste.
Special Precautions: Do not discharge to sewer systems, surface waters, or soil.
Relevant Regulations: Observe all local, regional, national, and international hazardous waste disposal regulations.
UN Number: UN2401
UN Proper Shipping Name: Piperidine
Transport Hazard Class(es): 3 (Flammable liquids), 8 (Corrosive substances)
Packing Group: II
Labels: Flammable liquid, Corrosive
Marine Pollutant: No
Other Information: Emergency response guide and placards required during transport. Must comply with regulations for flammable, corrosive substances by air, road, rail, and sea.
OSHA Status: Hazardous chemical as defined by OSHA Hazard Communication Standard
SARA Title III: Section 311/312 Immediate (acute) health hazard, fire hazard
TSCA: Listed on US Toxic Substances Control Act (TSCA) Inventory
EU Classification: Flammable, corrosive, acutely toxic, specific target organ toxin
Other Regulatory Listings: Listed or regulated by international chemical control regulations including REACH (EU), DSL (Canada), and others
Label Elements: Must show GHS pictograms for flammable, corrosive, acute toxicity.
