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Product Name: Phenylephrine Hydrochloride
CAS Number: 61-76-7
Molecular Formula: C9H13NO2·HCl
Molecular Weight: 203.67 g/mol
Synonyms: Phenylephrine HCl, Meta-Synephrine Hydrochloride
Recommended Use: Pharmaceutical ingredient, nasal decongestant
Manufacturer Information: Industrial chemical suppliers or pharmaceutical companies, contact for emergency information and supply chain details
Emergency Telephone: Refer to regional poison control center or local emergency number
Packaging: Sealed containers, tamper-proof packaging available for laboratories or hospitals
GHS Classification: Acute Toxicity (Oral) Category 4, Eye Irritation Category 2A
Hazard Statements: Harmful if swallowed, causes serious eye irritation
Pictograms: Exclamation mark, Health hazard
Signal Word: Warning
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Effects: Headache, nausea, increased blood pressure, burning sensation in eyes
Chronic Effects: Prolonged or repeated exposure may affect heart and central nervous system
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, use personal protective equipment
Other Hazards: Not classified as a carcinogen, mutagen, or reproductive toxicant under current data
Chemical Name: Phenylephrine Hydrochloride
Purity: >98% (pharmaceutical grade)
Impurities: Trace organic residues depending on synthesis pathway
Active Ingredient: Phenylephrine HCl
Excipient: None in bulk API form
Concentration: Single-component (100%) unless diluted for formulations
Inhalation: Remove to fresh air, monitor breathing, seek immediate medical attention if symptoms develop
Skin Contact: Remove contaminated clothing, thoroughly wash skin with water and soap, consult medical professional if irritation persists
Eye Contact: Immediately rinse eyes with water for at least 15 minutes, hold eyelids apart, seek medical care promptly
Ingestion: Do not induce vomiting, rinse mouth, keep patient calm, contact poison center or physician
Advice for Physicians: Treat symptoms, monitor cardiovascular and respiratory status, administer supportive measures
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: Strong water jet, as risk for contamination spread
Fire Hazards: May produce toxic fumes (hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide) under combustion
Special Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective clothing
Protective Actions: Evacuate area, fight fire from safe distance, prevent runoff water from entering drains or watercourses
Explosion Data: Not sensitive to mechanical impact or static discharge
Specific Hazards: Dust clouds could pose risk of ignition in confined spaces
Personal Precautions: Wear dust-proof mask, gloves, protective goggles, use local exhaust ventilation
Environmental Precautions: Avoid release into soil, drains, or rivers, use barriers to prevent environmental spread
Containment: Isolate area until clean-up complete, prevent dust generation
Cleaning Methods: Carefully collect spilled product using damp cloth or HEPA-filter vacuum, dispose waste in tightly sealed containers
Decontamination: Wash spill area thoroughly with soap and water after initial clean-up
Reporting: Notify relevant environmental and workplace safety authorities in case of large spill
Handling: Avoid contact with skin, eyes, and clothing, do not breathe dust, practice good hygiene, wash hands before eating or drinking
Technical Measures: Use in well-ventilated workspace, employ fume hood if available for research settings
Safety Measures: Store away from incompatible substances (strong oxidizers), keep away from food and drink
Storage Conditions: Store in original airtight container, keep in cool, dry place, protect from light and heat
Storage Incompatibilities: Do not store with acids, bases, or oxidants
Specific Applications: Use only as directed in controlled facility or under medical supervision
Control Parameters: No established occupational exposure limit for phenylephrine hydrochloride
Engineering Controls: Local exhaust or fume hood, laboratory standard ventilation
Personal Protective Equipment: Safety goggles, chemical-resistant gloves (nitrile or latex), lab coat, dust mask or respirator (if dust forms)
Environmental Controls: Prevent release to water or air, employ spill containment
Hygiene Measures: Do not eat, drink, or smoke in handling area, keep work clothes and personal clothes separate
Monitoring: Regular assessment for contamination in high-use settings, routine health monitoring suggested for frequent users
Appearance: White to off-white crystalline powder
Odor: Odorless
pH (solution): 3.5 – 5.5 (1% aqueous)
Melting Point: 143-146 °C
Boiling Point: Decomposes before boiling
Solubility: Freely soluble in water, soluble in alcohol
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log Pow): -2.1 (indicates high water solubility)
Density: 1.28 g/cm³
Flash Point: Not flammable
Viscosity: Not applicable (solid powder)
Explosive Properties: No known explosive properties
Oxidizing Properties: Not an oxidizer
Chemical Stability: Stable under recommended storage conditions
Reactivity: No hazardous reactions known under standard conditions
Conditions to Avoid: High temperature, exposure to light, moist air
Incompatible Materials: Strong oxidizers, strong acids and bases
Hazardous Decomposition Products: Toxic fumes of hydrogen chloride, nitrogen oxides, carbon monoxide may form under fire conditions
Polymerization: Will not undergo hazardous polymerization
Shelf Life: Generally 2-3 years in sealed container at prescribed temperatures
Acute Toxicity: LD50 (oral, rat): 350 mg/kg
Skin Corrosion/Irritation: Mild skin irritant
Serious Eye Damage/Irritation: Causes eye irritation
Respiratory/Skin Sensitization: Not classified as sensitizer
Germ Cell Mutagenicity: No data available on mutagenic effects in humans, not listed as mutagen based on animal data
Carcinogenicity: Not classified as carcinogen by IARC/NTP/OSHA
Reproductive Toxicity: Data in humans limited; high doses in animals may cause adverse fetal effects
Specific Target Organ Toxicity: May cause central nervous system stimulation, cardiovascular effects
Aspiration Hazard: Not considered an aspiration risk
Likely Routes of Exposure: Inhalation, ingestion, skin absorption
Symptoms: Hypertension, palpitations, headache, insomnia, nausea in acute overexposure scenarios
Ecotoxicity: Low toxicity to aquatic organisms based on available data
Aquatic Persistence: Expected to be persistent in water due to high solubility
Bioaccumulative Potential: Not expected to bioaccumulate (log Kow: -2.1)
Mobility: Mobile in soil and water; represents possible contamination risk if released
Degradability: Limited biodegradability in water or soil
Other Adverse Effects: May cause local impacts if undiluted material reaches surface waters; always prevent bulk release to environment
Waste Disposal Methods: Dispose as pharmaceutical or chemical waste in line with local and national regulations
Incineration: Use licensed disposal contractor, thermal destruction at high temperature recommended
Contaminated Packaging: Decontaminate and offer for recycling if possible, otherwise dispose as chemical waste
Precautions: Do not dispose in sink, drains, or regular landfill, keep out of reach of wildlife
Regulatory Requirements: Refer to regional, national, and local waste legislation for full disposal guidelines
UN Number: Not regulated as dangerous good under ADR/RID/IMDG/IATA
Transport Hazard Class: Not classified for transport
Packing Group: Not assigned
Proper Shipping Name: Phenylephrine Hydrochloride
Environmental Hazards: Not a marine pollutant
Special Precautions: Protect from direct sunlight and moisture during transport, use sealed, labeled packaging; maintain documentation for traceability
OSHA Status: Chemical not specifically listed as hazardous by OSHA
TSCA Inventory: Listed in the United States TSCA inventory
EU Regulations: Registered or pre-registered under REACH for pharmaceutical and laboratory use
Canadian WHMIS Classification: Not classified under current Canadian rules
SARA Title III: Not listed under SARA Title III Sections 302, 304, 313
Other Standards: Subject to regulation as a drug ingredient; listed in pharmacopeias (USP, EP, JP)
Labelling Requirements: Must include hazard identification, precautionary and safety data as per GHS and local guidelines
Other Legislation: Must follow local occupational safety laws and supply chain traceability for pharmaceuticals
