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Chemical Name: Phenyl Isothiocyanate
Chemical Formula: C7H5NS
Common Use: Reagent in organic synthesis, especially for the preparation of phenylthiocarbamoyl derivatives of amino acids
Physical State: Liquid at room temperature
Odor: Sharp, pungent
Appearance: Colorless to pale yellow oily liquid
Signal Word: Danger
Main Hazards: Irritating to eyes, skin, and respiratory system; harmful if swallowed, inhaled, or absorbed through the skin
Pictogram: Skull and crossbones, exclamation mark
Potential Health Effects: Eye irritation, skin burns, respiratory discomfort, potential allergic reactions, harm to internal organs if absorbed in sizeable quantities
Target Organs: Eyes, skin, mucous membranes, respiratory tract
Substance: Single compound
Active Ingredient: Phenyl Isothiocyanate (CAS Number: 103-72-0)
Purity: Often available at 98% or higher in laboratory settings
Eye Contact: Flush eyes with running water for at least 15 minutes, removing contact lenses after the first few minutes
Skin Contact: Wash affected area with soap and plenty of water
Inhalation: Move to fresh air, seek medical attention if symptoms worsen
Ingestion: Rinse mouth thoroughly with water; seek medical advice immediately
Immediate Medical Attention: Needed if exposure leads to persistent irritation, difficulty breathing, or other acute symptoms
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam
Hazardous Decomposition: Nitrogen oxides, sulfur oxides, toxic fumes
Protective Equipment for Firefighters: Full protective clothing including self-contained breathing apparatus
Special Hazards: Vapors may form explosive mixtures with air under certain conditions
Personal Precautions: Ventilate area, avoid breathing vapors
Environmental Precautions: Prevent spillage from entering drains, surface water, or soil
Clean-Up Methods: Absorb spill with inert absorbent material, collect in suitable container for disposal, wash spill site after material pickup
Handling: Use only in well-ventilated areas, employ proper PPE such as gloves and goggles, avoid contact with skin and eyes
Storage: Store in a tightly closed container, keep in a cool, dry, well-ventilated space away from sources of ignition and incompatible substances like strong acids or bases
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Special Considerations: Ensure containers remain upright and labeled properly
Respiratory Protection: Use an approved respirator if ventilation is insufficient
Skin Protection: Chemical-resistant gloves and lab coat
Eye Protection: Safety goggles, face shield if splashing is possible
Engineering Controls: Fume hood, eyewash stations, emergency showers
Other Protective Measures: Wash hands thoroughly after handling, remove contaminated clothing immediately
Form: Liquid
Color: Colorless to pale yellow
Odor: Pungent, sharp
Boiling Point: 221°C
Melting Point: -26°C
Flash Point: 107°C (closed cup)
Solubility: Slightly soluble in water, miscible with many organic solvents
Vapor Pressure: Low at room temperature
Stability: Stable under recommended storage conditions
Reactivity: May react with strong acids, bases, or oxidizing agents
Hazardous Polymerization: Not known to occur
Hazardous Decomposition Products: Toxic gases such as nitrogen oxides and sulfur oxides can be produced on combustion or decomposition
Routes of Exposure: Skin and eye contact, inhalation, ingestion
Acute Effects: Severe irritation to skin, eyes, and respiratory tract, symptoms such as coughing, burning sensation, headaches
Chronic Effects: Prolonged or repeated exposure can lead to sensitization, allergic reactions, or organ damage
LD50 Values: Oral LD50 (rat): reported between 640-800 mg/kg (published studies)
Carcinogenicity: Not classified as a carcinogen under major international standards
Ecotoxicity: Harmful to aquatic organisms
Persistence and Degradability: May persist in the environment and resist natural breakdown
Bioaccumulation: Potential to bioaccumulate exists; data limited
Precautions: Keep out of waterways, soils, and public sewer systems
Long-term Impact: Release into the environment carries risk of toxic effects to plants, fish, and invertebrates in aquatic systems
Waste Disposal: Treat as hazardous chemical waste; incinerate or dispose of through licensed chemical disposal contractor
Container Disposal: Triple rinse containers, puncture, then follow local and national regulations for hazardous waste
Regulatory Limitations: Never pour down the drain or release into the environment without proper treatment
UN Number: 2810 (Toxic Liquid, Organic, N.O.S.)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Transport Requirements: Ship in appropriate containers, properly labeled, compliant with international transport safety standards (including packaging and documentation requirements for hazardous chemicals)
Special Precautions: Ensure containers remain sealed, upright; handle spills or leaks according to hazardous substance protocols
OSHA (Occupational Safety and Health Administration): Regulated as a hazardous substance requiring hazard communication
TSCA (Toxic Substances Control Act): Listed
EU REACH: Subject to requirements concerning manufacture and use within the European Union
GHS Classification: Acute toxicity, skin and eye irritation, specific target organ toxicity
Local Requirements: Follow all workplace and environmental regulations concerning storage, handling, emissions, and disposal; SDS must remain accessible to all users handling this reagent
