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Product Name: Peroxidase
Synonyms: EC 1.11.1.7, Horseradish Peroxidase, HRP
Recommended Use: Laboratory reagent, diagnostics, research applications
Supplier: Refer to manufacturer or supplier information on the packaging
Contact Information: Emergency phone number and additional contact details should be listed directly by the product supplier
CAS Number: 9003-99-0
UN Number: Not classified as hazardous for transport under most regulations
Revision Date: As stated by supplier documentation or product label
Classification: Not classified as a hazardous substance according to GHS systems for most formulations, except for concentrated dusts and enzyme preparations
Main Hazards: Possible respiratory sensitization in persons repeatedly exposed to dry powders. Considered an irritant to eyes, skin, and respiratory tract if mishandled. Not expected to cause severe acute effects in standard laboratory use.
Label Elements: Avoid inhalation of dust. Prevent eye and skin contact.
GHS Pictograms: Exclamation mark for irritant effects with precaution to avoid dust generation.
Chemical Name: Peroxidase, Horseradish Source
Purity: Enzyme preparations typically over 90% activity (by weight); may contain stabilizers (phosphate buffers or salts)
Impurities: Trace plant proteins, stabilizing salt, low levels of sodium azide (preservative in some lots, typically <0.1%), water
Hazardous Components: No major hazardous chemical ingredients in usual formulations; dust may cause respiratory effects due to protein content.
Inhalation: Move to fresh air. Seek medical attention if irritation or symptoms persist.
Skin Contact: Rinse with water and mild soap for at least 15 minutes. Remove contaminated clothing.
Eye Contact: Hold eyelids open and rinse with plenty of water for at least 15 minutes. Consult doctor if irritation remains.
Ingestion: Rinse mouth with water (do not swallow rinse). Do not induce vomiting. Get medical help if larger quantities were swallowed or symptoms develop.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Special Hazards: Protein decomposition may occur above 180°C. Special combustion gases such as ammonia, oxides of nitrogen, oxides of carbon. While not considered flammable, dried enzyme dust could support combustion if mixed with finely divided organic matter.
Protection for Firefighters: Wear self-contained breathing apparatus and protective gear. Prevent run-off from entering drains because residue might load oxygen demand in surface waters.
Explosive Limits: Not established. Protein powders rarely form explosive dust clouds under practical laboratory conditions, but avoid excessive dust formation.
Personal Precautions: Wear protective gloves, goggles, and dust mask or respirator if powder is released. Avoid creating airborne dust.
Environmental Precautions: Prevent entry to water bodies and drains. Not toxic at environmental concentrations, but proteins can exert a biological oxygen demand.
Clean Up Methods: Sweep or vacuum material with HEPA filtration, minimizing dust. Rinse area with detergent and plenty of water. Dispose of contents as local regulations allow for laboratory bioactive proteins.
Handling: Use in well-ventilated area. Avoid inhalation and direct contact with skin, eyes, and clothing. Open containers with care to minimize dust.
Storage: Store in tightly sealed containers at 2–8°C (refrigerated) unless otherwise directed. Protect from moisture and light. Store separately from strong oxidizers and acids.
Incompatibilities: Strong oxidizing agents, acids or bases in concentrated forms, agents that might denature protein
Occupational Exposure Limits: No specific OSHA or ACGIH limits for peroxidase enzyme; for protein dusts, maintain airborne concentrations as low as possible under 1 mg/m³
Engineering Controls: Local exhaust ventilation, fume hood
Personal Protective Equipment (PPE): Protective laboratory gloves, eye protection (goggles or face shield), laboratory coat, and N95 respirator for handling dry powders
Hygienic Practices: Wash hands after handling. Do not eat or drink in laboratory areas
Appearance: Off-white or brown powder, sometimes as a solution (light to dark brown)
Odor: Slight proteinaceous; not strong
pH: 6.0–8.0 (aqueous solution, typical preparations)
Melting/Freezing Point: Not applicable
Boiling Point: Decomposes on heating well below boiling
Flash Point: Not determined; low risk
Solubility: Freely soluble in water
Density: 1.3–1.5 g/cm³ for dried proteins
Partition Coefficient (Log Kow): Not applicable
Decomposition Temp: >180°C
Vapor Pressure: Not applicable (non-volatile solid protein)
Chemical Stability: Stable under recommended storage conditions. Loses activity rapidly with increased temperature, pH extremes, or long exposure to air.
Conditions to Avoid: Exposure to heat, strong oxidizers, acids, or bases, repeated freeze-thaw cycles
Incompatible Materials: Strong acids, strong bases, oxidizers, organic solvents (may cause denaturation)
Hazardous Decomposition Products: Oxides of nitrogen, ammonia, carbon oxides under fire conditions. No known hazardous polymerization
Acute Toxicity: Not considered acutely toxic by oral, dermal, or inhalational routes in laboratory animals
Skin Irritation: May cause mild irritation in sensitive individuals, mainly with repeated or prolonged exposure
Eye Irritation: Possible irritation if splashed in eyes, usually transient
Respiratory Sensitization: Occupational allergy reported for some enzyme preparations. Risk increases with repeated and prolonged exposure to airborne dusts
Chronic Effects: No evidence for carcinogenicity, mutagenicity, or reproductive toxicity
Medical Conditions Aggravated by Exposure: Asthma, allergy to plant proteins may lead to stronger, earlier reactions
Ecotoxicity: Not expected to be environmentally hazardous in most circumstances. Large spills may deoxygenate water and disturb aquatic microflora due to rapid protein degradation.
Persistence and Degradability: Rapidly biodegrades by microbial action
Bioaccumulative Potential: Not expected to bioaccumulate; large protein molecule broken down quickly
Mobility in Soil: Substances disperse with water, subject to rapid decomposition
Other Adverse Effects: No additional information; standard enzyme solutions do not persist or pose chronic environmental risks
Disposal Methods: Collect in sealed containers and treat as laboratory waste. Can be degraded by autoclaving then disposed via sewer with copious water (if allowed by local legislation), or to landfill in accordance with institutional and municipal guidelines.
Special Considerations: Avoid disposal of large amounts to surface water or ground drains to prevent oxygen depletion and biological overload
Contaminated Packaging: Rinse and treat as chemical waste. Adhere to national and local regulations
UN Number: No UN number assigned (not classified as dangerous goods under ADR, IATA, IMDG)
Transport Hazard Class: Not regulated
Packing Group: Not regulated
Label: Not required beyond standard non-hazardous label
Special Precautions: Avoid generating dust during transport. Protect containers from mechanical damage and brief exposure to temperature extremes
GHS Classification: Not hazardous under GHS/CLP for most preparations; chronic allergen warning for some enzyme formulations
OSHA Standard: Not specifically regulated
TSCA Status: Enzyme preparations are often exempt; check supplier declarations
REACH Status: Registration exempt as a natural protein unless mixed with listed hazards
Other Regulations: Not listed as a hazardous waste in major regulations. Follow all applicable institutional policies and local ordinances for safe handling and disposal
