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Product Name: Penicillin-Streptomycin Solution
Synonyms: Pen-Strep, Penicillin G Sodium with Streptomycin Sulfate
Recommended Use: Antimicrobial agent for cell culture
Manufacturer: Refer to supplier label for detailed contact information
Emergency Phone Number: Provided on label or manufacturing documentation
Product Code: Listed on purchase or shipping paperwork
Relevant Identified Uses: Laboratory chemical
Email Address: Contact supplier or source for detailed information
Classification: Skin sensitizer (Category 1), Respiratory sensitizer (Category 1), Eye irritant (Category 2A), Target organ toxicity (single exposure, Category 3)
Signal Word: Warning
Hazard Statements: May cause allergic skin or respiratory reactions, Causes serious eye irritation, May cause drowsiness or dizziness
Precautionary Statements: Avoid breathing mist or spray, Wash hands thoroughly after handling, Wear protective gloves/eye protection/face protection, Use only outdoors or in a well-ventilated area, Take off contaminated clothing and wash before reuse
Pictograms: Exclamation mark, Health hazard symbol
Physical Hazards: Not classified as flammable or explosive under normal conditions
Other Hazards: May have environmental impact if released in large quantities
Health Hazards: Allergic reactions are possible in sensitized individuals
Penicillin G Sodium: CAS No. 69-57-8, Concentration: 5,000–10,000 units/ml
Streptomycin Sulfate: CAS No. 3810-74-0, Concentration: 5–10 mg/ml
Sodium Chloride: Minor component, used for isotonicity
Water for Injection: Remainder to volume, carrier solvent
Preservatives & Excipients: May include trace stabilizers; check supplier's more detailed breakdowns for latest formulation specifics
Impurities: Unlikely to be present above thresholds requiring declaration under standard laboratory practices
Inhalation: Move person to fresh air, support breathing if necessary, seek medical advice if symptoms appear
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, get medical attention if irritation develops
Eye Contact: Rinse eyes with plenty of clean water for at least 15 minutes, lift upper and lower eyelids occasionally, call a physician if irritation persists
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical attention if symptoms occur or persist
Acute Symptoms: Allergic skin or respiratory reactions, mild to moderate eye and skin irritation
Delayed Symptoms: Sensitization that could lead to asthmatic symptoms during subsequent exposures
Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Hazards from Combustion Products: Emits toxic fumes (carbon oxides, nitrogen oxides, sulfur oxides) during combustion
Protective Equipment: Firefighters should wear full protective gear including self-contained breathing apparatus
Special Procedures: Avoid inhalation of combustion products, remove containers from fire area if safe, cool containers with water if exposed to fire
Other Remarks: Product does not readily combust; primary risks are related to decomposition fumes and environmental release during firefighting activities
Personal Precautions: Use personal protective equipment including gloves, lab coat, eyewear, and mask
Environmental Precautions: Prevent further leakage or spillage if safe, avoid runoff into sewers and water bodies
Methods for Cleaning Up: Soak up with inert absorbent material (e.g., sand, vermiculite), place into closed container for disposal.
Spill Area Ventilation: Ensure adequate ventilation when cleaning up
Decontamination Procedures: Wash spill site after material pickup is complete
Disposal: Dispose of in an approved chemical waste container following institutional or local regulations
Precautions for Safe Handling: Handle in a chemical fume hood or well-ventilated space, avoid skin and eye contact, minimize dust or aerosol formation, use proper laboratory techniques
Storage Conditions: Store at 2–8°C (refrigerated), protect from light, keep containers tightly closed when not in use
Incompatible Materials: Strong oxidizers, acids, bases; consult supplier for more information
Hygiene Practices: Wash hands before breaks and after handling, no eating or drinking in working area
Special Handling Guidance: Train personnel in safe handling prior to use, maintain up-to-date records of chemical inventory and use
Control Parameters: No established workplace exposure limits for the mixture; consider occupational limits for pharmaceutical dusts
Engineering Controls: Use with local exhaust ventilation or in fume hood
Personal Protective Equipment: Protective gloves (nitrile or latex), safety glasses or goggles, lab coat, mask or respirator as needed for airborne exposure
Respiratory Protection: Required for high aerosol potential or large-scale handling
Environmental Controls: Avoid release into the environment, maintain spill kits and absorbents in the area
Appearance: Clear to slightly yellowish solution
Odor: Odorless or faint pharmaceutical smell
pH: 6.0–8.0 (typical for pharmaceutical saline solutions)
Melting/Freezing Point: Components stable in solution above freezing
Boiling Point: Similar to water, above 100°C
Flash Point: Not applicable (aqueous solution)
Vapor Pressure: Similar to water
Solubility: Completely soluble in water
Relative Density: Close to 1.0 g/cm³
Partition Coefficient (n-octanol/water): Not applicable for aqueous preparation
Viscosity: Low, similar to water
Decomposition Temperature: Breakdown may occur at temperatures above 100°C producing harmful gases
Chemical Stability: Stable under normal laboratory conditions and appropriate storage
Hazardous Reactions: No dangerous reactions known under recommended use; avoid mixing with incompatible substances
Conditions to Avoid: Excess heat, freezing, light exposure for extended periods
Materials to Avoid: Strong acids, strong bases, strong oxidizing agents
Hazardous Decomposition Products: Carbon oxides, sulfur oxides, nitrogen oxides under fire conditions
Polymerization: Will not occur
Routes of Exposure: Skin, eyes, inhalation, ingestion
Acute Toxicity: Not acutely toxic at laboratory-use concentrations; accidental injection could cause allergic or hypersensitivity response
Chronic Exposure: Risk of sensitization and allergic reactions with repeated exposure, especially in individuals with prior antibiotic allergies
Symptoms: Skin rash, difficulty breathing, conjunctivitis, nausea, headache
Target Organs: Immune system, skin, respiratory tract
Carcinogenicity: Components not listed as known carcinogens by IARC, NTP, OSHA
Mutagenicity/Reproductive Toxicity: Penicillins and streptomycin not considered to pose significant reproductive risks in laboratory settings, but limited occupational experience is available
Other Data: People with known allergies to beta-lactam antibiotics or aminoglycosides may be at elevated risk
Aquatic Toxicity: May affect aquatic organisms and bacteria at high concentrations; low environmental persistence due to breakdown in environment
Persistence/Degradability: Biodegradable by standard environmental processes
Bioaccumulation: Not bioaccumulative
Mobility in Soil: Mobile in aqueous phase, no known risk of sediment accumulation
Other Adverse Effects: Wastewater containing reagent should be minimized; disrupts microbial flora if released into environment in bulk
Waste Disposal Methods: Dispose according to institutional, local, and federal regulations for pharmaceutical waste
Container Handling: Triple rinse empty containers, puncture and dispose as hazardous waste
Recommended Practices: Label and segregate antibiotic waste to avoid environmental or clinical cross-contamination;
Environmental Cautions: Do not dispose of in household waste or sanitary sewer
Contaminated Packaging: Dispose of unused product and packaging via approved hazardous waste disposal contractor
UN Number: Not classified as hazardous for transport under most chemical safety codes
Proper Shipping Name: Laboratory reagent, not dangerous for transport
Transport Hazard Class: No specific class; follow general laboratory chemical shipping protocols
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant at laboratory quantities
Special Precautions for Users: Use insulated or cold packs for shipping, prevent leaks during all handling and transit
Regulatory Transport Labels: Standard laboratory chemical label requirements apply
Inventory Listings: Listed or exempted under TSCA, DSL, EINECS/ELINCS, and other relevant chemical inventories
OSHA Hazards: Eye, skin, and respiratory irritant, sensitizer
SARA Title III: Not subject to specific reporting under Sections 302, 304, or 313
California Prop 65: Not listed as a known carcinogen or reproductive toxin
WHMIS Classification (Canada): D2B – Toxic material causing other toxic effects
EU Regulations: Hazard Statements H317, H334 (sensitizer), H319 (eye irritation)
Other Requirements: Use of product governed by institutional chemical hygiene and laboratory safety plans
