© 2026 Nanjing Finechem Holdings Co., Ltd,
All Right Reserved
Product Name: p-Toluenesulfonyl Isocyanate
Synonyms: Tosyl Isocyanate, PTSCI
CAS Number: 4083-64-1
Manufacturer: Commonly produced by specialty chemical suppliers worldwide
Recommended Uses: Intermediate for pharmaceuticals, agrochemicals, chemical synthesis
Restrictions on Use: Use only for industrial applications and by trained staff
Contact Information: Available through chemical supply chain safety departments
Classification: Toxic if inhaled, Skin corrosion/irritation (Category 1), Eye damage (Category 1), Respiratory sensitizer (Category 1), Hazardous to aquatic life
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage, fatal if inhaled, may cause respiratory irritation or allergic symptoms, hazardous to aquatic life
Pictograms: Skull and crossbones, Corrosion, Exclamation mark, Environment
Precautionary Statements: Avoid breathing vapors, use only outdoors or in well-ventilated areas, wear protective gloves/clothing, eye and face protection, avoid release to environment without adequate control
Chemical Name: p-Toluenesulfonyl Isocyanate
CAS Number: 4083-64-1
Concentration: 99% or higher pure material, trace impurities vary by supplier
Inhalation: Move to fresh air quickly, seek immediate medical attention, administer oxygen if breathing is labored, do not leave victim unattended
Skin Contact: Remove contaminated clothing, wash with plenty of water for at least 15 minutes, seek medical attention
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy, continue rinsing, rush to healthcare provider
Ingestion: Rinse mouth, never give anything by mouth if unconscious, seek prompt medical attention, do not induce vomiting
Most Important Symptoms/Effects: Burns to skin, eyes, respiratory tract irritation, potential delayed allergic responses
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, water spray to cool containers
Specific Hazards from Fire: Emits toxic fumes of oxides of nitrogen, sulfur oxides, carbon monoxide, carbon dioxide
Protective Equipment and Precautions: Firefighters use self-contained breathing apparatus and protective clothing, evacuate area, stay upwind
Special Information: Containers may explode in heat, runoff may cause pollution
Personal Precautions: Evacuate area, ventilate, don chemical-resistant gloves, eye protection, respirator
Environmental Precautions: Prevent release into environmental drains or waterways; alert authorities
Methods for Cleanup: Absorb with inert material like sand or vermiculite, collect in closed container for disposal, decontaminate spill area with dilute ammonia or sodium carbonate solution, ventilate area well
Handling: Work only with appropriate exhaust ventilation, avoid contact with skin, eyes, clothing, keep away from incompatible substances such as water, strong bases, acids
Storage: Keep container tightly closed, store in cool, dry, well-ventilated space, keep away from moisture, lock up product, segregate from reactive chemicals
Exposure Limits: No specific values established by OSHA or ACGIH; minimize exposure
Engineering Controls: Chemical fume hood, safety shower, eyewash stations
Personal Protective Equipment: Nitrile gloves, flame-resistant lab coat, tightly fitted goggles, face shield, appropriate respirator
Hygiene Measures: Do not eat, drink, or smoke in work area, wash hands before breaks and after handling, decontaminate protective equipment after use
Appearance: Colorless to yellow liquid
Odor: Pungent, irritating, sharp odor
Odor Threshold: Not established
pH: Not applicable
Melting Point/Freezing Point: -10°C to 0°C (approximate)
Boiling Point/Range: 142°C to 145°C at 760 mmHg
Flash Point: 95°C (Closed cup)
Evaporation Rate: Not documented
Flammability: May burn, flammable limits not determined
Vapor Pressure: 0.1 mmHg at 25°C
Vapor Density: Heavier than air
Solubility: Hydrolyzes in water, soluble in organics such as benzene, acetone
Partition Coefficient: Not determined
Decomposition Temperature: Tends to decompose above boiling point
Viscosity: Not measured
Density: 1.234 g/cm³ at 20°C
Reactivity: Reacts violently with water, alcohols, amines, bases, acids
Chemical Stability: Stable under recommended storage conditions, instability arises with exposure to moisture, light
Possibility of Hazardous Reactions: Formation of toxic gases like sulfur dioxide, nitrogen oxides, carbon monoxide
Conditions to Avoid: Moist air, heat, sunlight, sources of ignition, incompatible chemicals
Incompatible Materials: Water, strong acids, strong bases, alcohols, amines
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides, carbon monoxide, carbon dioxide
Acute Toxicity: Harmful if inhaled or swallowed, toxicological assessments show LC50/LD50 values in low dosage for animal models; precise data depends on animal species and exposure method
Skin Corrosion/Irritation: Severe corrosive actions on skin, rabbits show full-thickness necrosis
Serious Eye Damage/Eye Irritation: Risks full destruction of eye tissue and sight
Respiratory Sensitization: Exposure leads to asthmatic reactions in some individuals
Repeated Dose Toxicity: Long-term exposure increases risk of allergy, bronchitis, dermatitis
Mutagenicity/Carcinogenicity: No well-documented evidence of mutagenicity or carcinogenicity
Other Information: Acute exposure by inhalation may be rapidly fatal due to respiratory injury, symptoms may develop hours after contact
Toxicity: Toxic to aquatic life even in small concentrations
Persistence and Degradability: Rapid decomposition in moist environments, breakdown products are mobile, may harm fish, invertebrates
Bioaccumulative Potential: Not expected due to hydrolysis, but no comprehensive studies
Mobility in Soil: Highly reactive, does not persist
Other Adverse Effects: Localized releases can cause fish kills, threat to aquatic invertebrates, rapid action needed during spills
Waste Disposal Methods: Collect and store waste for disposal at certified chemical waste facility, incinerate in approved high-temperature plants, neutralization may aid disposal
Contaminated Packaging: Triple rinse containers with ammonia or sodium carbonate, destroy packaging as hazardous material
Precautions: Do not dump in drains, sewer, or environment, consult local authorities for proper chemical waste regulations, record all disposal
UN Number: 2206
UN Proper Shipping Name: ISOCYANATES, TOXIC, LIQUID (includes p-Toluenesulfonyl Isocyanate)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Marine Pollutant: Yes
Special Precautions for User: Protect containers from physical damage, segregate from foodstuffs, prepared emergency response plan during shipment, ensure correct placarding and documentation
OSHA Status: Hazardous chemical under OSHA Hazard Communication Standard
TSCA Status: Listed under Toxic Substances Control Act
EINECS/ELINCS: Listed
WHMIS Classification: D1A, D2A, E (Canada)
SARA Title III: Not covered under Section 313, included as an immediate (acute) health hazard
REACH Registration: Required when imported into Europe above legal threshold
Other Local Regulations: Subject to workplace and environmental controls, strict storage and handling protocols applied in most countries, employers must provide hazard communication and exposure control training
