© 2026 Nanjing Finechem Holdings Co., Ltd,
All Right Reserved
Product Name: p-Anisidine
Synonyms: 4-Methoxyaniline, p-Aminoanisole, 1-Amino-4-methoxybenzene
Chemical Formula: C7H9NO
Molecular Weight: 123.15 g/mol
CAS Number: 104-94-9
Recommended Use: Laboratory reagent, chemical intermediate in dye and pharmaceutical synthesis
Manufacturer Information: Listed on supplier packaging
Emergency Phone Number: Sourced from manufacturer documentation or local emergency services
Contact for Information: Safety manager or chemical handling supervisor listed locally
Classification: Acute toxicity (oral, dermal, inhalation), skin irritation, eye irritation, mutagenicity, aquatic toxicity
Label Elements: Danger, toxic if swallowed, causes damage to organs, harmful to aquatic life
Signal Word: Danger
Hazard Statements: H301: Toxic if swallowed; H311: Toxic in contact with skin; H331: Toxic if inhaled; H302: Harmful if swallowed
Precautionary Statements: Avoid all skin and eye contact, thoroughly wash hands after handling, prevent release to the environment, always use protective gear
Routes of Entry: Inhalation, ingestion, skin contact, eye contact
Symptoms of Exposure: Headache, dizziness, methemoglobinemia with possible cyanosis, abdominal pain, vomiting, skin or eye irritation
Chemical: p-Anisidine
CAS Number: 104-94-9
Concentration: >99% pure material
Impurities: Traces of 4-nitroanisole, 4-chloroanisole (typical in technical grade)
Other Ingredients: None significant for classification purposes
Inhalation: Move person to fresh air quickly. If breathing becomes difficult, provide oxygen. Seek medical attention immediately for symptoms like shortness of breath or dizziness.
Skin Contact: Remove contaminated clothing right away. Wash exposed skin with moderate water and soap for 15 minutes. If redness, swelling, or persistent irritation develops, get medical attention.
Eye Contact: Rinse eyes thoroughly with clean, running water for at least 15 minutes, lifting eyelids to ensure complete irrigation. Seek emergency medical evaluation if pain or visual changes persist.
Ingestion: Do not cause vomiting. If person is conscious, give water if instructed by medical personnel. Seek immediate help, bring material safety information for clinical staff.
Symptoms Delayed: Hemolysis, methemoglobinemia (which can cause blue skin, weakness, confusion, rapid heartbeat); these effects require prompt medical evaluation.
Suitable Extinguishing Media: Use foam, dry chemical, or carbon dioxide for small fires. Water spray should be used to cool containers but not on active chemical fire.
Specific Hazards: Heating releases toxic gases including nitrogen oxides, carbon monoxide, and possibly aniline vapors. In sealed containers, material can ignite explosively upon intense heat.
Protective Equipment: Firefighters must use full self-contained breathing apparatus and chemical-resistant clothing.
Precautions: Approach fire from upwind area, avoid run-off from fire control which could contaminate waterways.
Personal Precautions: Evacuate the spill zone, ventilate the area well, wear gloves, protective clothing, goggles and appropriate respirator. Remove all ignition sources and prevent dust or vapor formation.
Environmental Precautions: Prevent chemical from entering sewers, surface or ground waters. Use earth or sand to contain spills if necessary.
Methods for Clean-Up: Collect spilled solid gently using non-sparking tools. Transfer to tightly sealed, clearly marked waste containers. For liquid spills, absorb with vermiculite or chemically inert absorbent, then collect for proper disposal. Remember to ventilate and wash spill area after material collection.
Decontamination: Clean residual area with plenty of water and detergent. Disposal of all contaminated cleaning materials must go to hazardous waste facility.
Safe Handling: Always use in a chemical fume hood or well-ventilated location. Avoid skin or eye contact, do not eat, drink or smoke when handling p-Anisidine. Wear gloves and protective eye equipment.
Storage Conditions: Store in cool, dry, well-ventilated environment in original containers or in chemical-resistant packaging and tightly closed. Keep away from direct sunlight, sources of ignition and incompatible materials.
Incompatibilities: Acid chlorides, anhydrides, strong oxidizers, various metals
Hygiene Measures: Wash hands thoroughly after handling, keep work clothing separate from other laundry, change contaminated clothing promptly.
Exposure Limits: OSHA PEL: none specific; ACGIH TLV: 0.5 mg/m³ (skin)
Engineering Controls: Use local exhaust ventilation, fume hood or closed system operation.
Personal Protective Equipment: Chemical-resistant gloves (nitrile, butyl rubber), impact-resistant goggles, long-sleeved lab coat or coveralls.
Respiratory Protection: Certified respirator (cartridge for organic vapors/particulates) for non-ventilated scenarios. Use higher protection for large-scale use.
Environmental Exposure Controls: Prevent chemical release to environment, use containment and proper waste collection for routine or accidental emissions.
Appearance: Pale brown to dark yellow crystals or powder
Odor: Slightly amine-like, sweet
pH: Not available as solid; moderately alkaline when dissolved
Melting Point: 57-59°C
Boiling Point: 243-245°C
Flash Point: 117°C (closed cup method)
Evaporation Rate: Not readily volatile at room temperature
Flammability: Combustible solid, fire risk from dust or vapor
Vapor Pressure: Less than 1 mmHg at 20°C
Solubility: Low solubility in water, freely soluble in alcohol, ether, chloroform
Density: 1.10–1.12 g/cm³
Partition Coefficient (log Kow): 1.18
Autoignition Temperature: 470°C
Chemical Stability: Usually stable under recommended storage and use conditions, but may oxidize or darken on exposure to air or light.
Reactivity: Sensitive to strong acids, strong oxidizing agents and acid anhydrides, which can trigger rapid and exothermic reactions.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, aniline derivatives
Conditions to Avoid: High temperatures, open flames, presence of strong oxidizers or acids
Polymerization: Not expected under normal handling
Corrosiveness: Not corrosive to metals under normal conditions; can attack some rubber or soft plastics over time
Acute Toxicity: Oral LD50 (rat) about 200 mg/kg; dermal LD50 (rabbit) 1200 mg/kg; inhalation LC50 data is limited but estimated at high risk at low concentrations
Chronic Effects: Repeated exposure may cause methemoglobinemia, kidney and liver injury, anemia.
Carcinogenicity: Not classed as carcinogenic by IARC; ACGIH lists as A3 (not classifiable as a human carcinogen). Caution required as aromatic amines often linked to mutagenic and carcinogenic effects.
Mutagenicity: Some positive mutagenicity results in bacterial and mammalian cell mutagen tests
Reproductive Toxicity: No clear human data, but structurally related compounds pose risk.
Irritation: Causes severe irritation to eyes, skin, respiratory tract.
Sensitization: Rare reports of allergic contact dermatitis after skin exposure
Aquatic Toxicity: Harmful to aquatic organisms; LC50 (fish) approx. 0.2-1.0 mg/L/96h
Persistence and Degradability: Degrades slowly in the environment; not readily biodegradable
Bioaccumulation: Low to moderate potential; log Pow of 1.18 suggests limited bioaccumulation
Mobility in Soil: Moderate; may migrate to groundwater if released
Other Adverse Effects: Toxic to some microorganisms; local effects persist after large spills
Precautionary Practices: Avoid uncontrolled releases, always treat wash-down water as potential hazardous waste
Waste Disposal: Handle as hazardous waste; incinerate at facilities that accept chlorinated aromatic amines or use chemical treatment approved for aromatic amines
Container Disposal: Empty containers must be triple rinsed and treated as hazardous unless completely and verifiably decontaminated
Methods: Consult local regulations for hazardous waste; do not pour down drains or mix with landfill waste
Recovery or Recycling: Typically not practical for p-Anisidine in lab or industrial setting
Storage before Disposal: Keep securely, clearly labeled, away from incompatible substances awaiting collection by licensed waste handlers
UN Number: UN 3452
UN Proper Shipping Name: p-Anisidine (4-Methoxyaniline)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Labels: Toxic, Keep away from foodstuffs and animal feeds
Special Precautions for User: Ship only in tightly sealed, chemical-resistant containers, protected from mechanical shock and heat; ensure vehicle ventilation and labeling
DOT/ADR/IATA/IMDG: Compliant with each respective regional transportation authority
Environmental Danger: Marine pollutant, avoid shipment with edible goods or in bulk near waterways
US Federal Regulations: Listed on TSCA; SARA 302/313 reportable due to toxicity
EU Regulations: REACH registered, subject to restrictions for hazardous aromatic amines
Canada (DSL/NDSL): Listed on Domestic Substances List
Labeling Requirements: GHS-compliant pictograms, hazard and precaution statements in English and local language
Other Labels: Must show appropriate risk and safety phrases, handling instructions, and emergency contact
Occupational Restrictions: Stringent guidelines in chemical and dye production, restricted laboratory use to trained professionals
International Inventories: Registered in chemical inventories across major jurisdictions including Japan ENCS, China IECSC, Australia AICS
