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Moving molecules through fluids to separate them by density has given science some of its simplest, yet most powerful, tools. Iodixanol, the main ingredient in OptiPrep, represents a later chapter in that story. Early on, researchers pushed around sucrose and cesium chloride, trying to split apart cells and viruses for a better look. Sucrose got sticky and viscous at high concentrations, and fragile samples suffered. Fast forward to the molecular biology boom, the need to handle delicate proteins and cells in their native state led labs to search for something gentler but effective. Iodixanol—formulated first for medical imaging to avoid damaging tissue—entered the life science scene as a much lighter touch. Now, instead of relying on brute force with dense, hyperosmotic solutions, researchers gained a tool that could create sharp separations without fried cells or busted vesicles. Its use spread through labs needing virus purification, subcellular fractionation, or even exosome isolation—fields that barely existed in the early gel layers days. The shift to iodixanol-rich media like OptiPrep changed the expectation of what a gradient medium could actually deliver, both for yield and preservation of biological function.
OptiPrep stands out as an aqueous solution of iodixanol, packing a density punch suitable for intricate separations but gentle on labile samples. The product comes at 60% weight/volume, which means it starts dense enough to cover organelle work, viruses, or plasma membrane prep, but can be diluted down for lighter-duty jobs. Traditional density gradients often introduced issues with osmolality, so OptiPrep was formulated to stay close to physiological levels—a crucial point that can mean the difference between clean separation or cell lysis. What sets OptiPrep apart from older options is its versatility: it refuses to precipitate common proteins and supports both continuous and step gradient formats. It’s one of the few gradient media that the scientists on both sides of the “biochemistry versus cell biology” line trust in their protocols.
On lab benches, OptiPrep appears as a clear, colorless solution—a stark contrast with cloudy or syrupy alternatives. Iodixanol, a nonionic molecule, gives OptiPrep its high density without stacking up osmolality. It swirls easily, and its viscosity doesn't slow down pipetting or delay gradient formation. Some competing gradients settle out of solution or cause sediment, frustrating anyone seeking reproducible results, but this compound stays stable whether sitting in the fridge or running through a centrifuge. Its molecular weight lands around 1550 g/mol, but its impact comes more from the arrangement of iodine atoms, which create density without piling on ionic strength.
Every container lists iodixanol concentration at 60% weight/volume, with osmolality carefully adjusted to mimic physiological conditions—around 290 mOsm/kg water. The pH sits close to neutrality, usually within 6.5 to 7.5. Manufacturers run each batch through stringent sterility checks and use low-endotoxin water to avoid adding artifacts to sensitive experiments. Each label also notes storage at 2–8ºC—those who stray from this rule often see reduced performance. It’s not enough for labels to shout purity; those working with EVs or rare cell types need confirmation there’s no interference from anionic or cationic detergents, since trace components can sabotage weeks of prep work. Several rounds of verification—UV spectroscopy for purity, HPLC for breakdown products—back up every claim on the bottle.
Setting up a density gradient with OptiPrep usually means blending stock with suitable diluents—often buffered saline or culture media. Unlike those messy, syrupy gradients where layer intermixing leads to wobbly separations, OptiPrep layers pour smoothly and stay put. Generating a continuous gradient by mixing dilutions with a gradient maker rewards patience with slick, reproducible barriers. In the hands of an attentive technician, separation lines between layers can look razor sharp. I’ve found that following published dilution schemes for exosome or virus isolation yields predictable results, but tinkering with those protocols fine-tunes recovery for oddball samples. Cold prep and gentle pipetting protect labile vesicles, and this approach spares researchers from losing fragile organelles to osmotic shock.
Iodixanol resists breaking down or reacting with most common biomolecules, avoiding the unpredictable cross-reactions that haunt other separation media. This inertness comes from its structure—rings of carbons and hydrophilic side groups block most nucleophiles or oxidants from slicing it up. Any chemical tweaking tends to focus on buffer choice or adding stabilizers for special applications; the core molecule rarely gets altered. Surface binding doesn’t plague it like some polysaccharide-based media, especially when targeting extracellular vesicle isolations where stickiness can throw off results. For applications needing even higher selectivity, some groups add gradient supplements or affinity layers, but not by modifying the iodixanol itself. Its stubborn chemical stability makes it a steady hand in workflows that reply on repeatability.
OptiPrep gets used interchangeably with “Iodixanol Solution” or “60% Iodixanol.” Some catalogs list it under “Density Gradient Medium” or “Isoosmotic Iodixanol Solution.” The multiplicity of names in research papers, including formulations with brand or generic titles, reflects broad adoption—someone reading an exosome isolation protocol from Norway or a liver mitochondria study from Boston quickly recognizes OptiPrep as the same backbone, regardless of branding or regional distribution differences.
OptiPrep usually lands in the safer end of chemical lists, but it still commands respect under standard lab safety routines. Direct contact with eyes or mucous membranes causes irritation, so gloves and goggles become habits. Its roots in intravenous imaging agents mean the toxicology profile gets tested extensively—though pure iodixanol isn’t designed for injection in this context, so inhalation and accidental skin absorption should be avoided. Laboratory fume hoods help keep exposures minimal, especially during large-scale prep. Disposal goes through chemical waste streams since the iodine content, while relatively mild compared to halogenated solvents, shouldn’t head straight to municipal drains. For training, I insist new technicians read material safety data and rehearse spills response, since one mistaken assumption tends to cause the worst accidents.
Modern cell biology, virology, and neurobiology all pull OptiPrep into critical protocols. Purification of viral particles, separation of extracellular vesicles, and fractionation of organelles like nuclei or endosomes all benefit. I’ve personally used OptiPrep gradients to enrich viral vectors for gene therapy, which requires keeping viral surface proteins intact and separation sharp enough to weed out empty capsids. Clinical labs isolate plasma membranes, brain synaptosomes, and lysosomes for downstream omic work, tracing changes in health and disease. Plant biologists rescue chloroplasts from tissue soup, while neurobiologists fish out axonal vesicles. Each application depends on the combination of high density, low viscosity, and biological compatibility—traits that older iodinated compounds or polysaccharide gradients just couldn't balance.
Behind every reliable gradient lies an ongoing cycle of research—testing batch stability, purifying intermediates, and validating consistency. Formulation improvements focus on reducing contaminants, matching buffer systems to emerging omics techniques, and extending shelf life for global distribution. Teams chase improvements in gradient linearity or shelf-stability at higher concentrations, especially as researchers push toward single-vesicle analysis or ultra-fine organelle fractions. Open questions steer current R&D—especially around standardizing protocols for exosome isolation from biofluids, which matters for biomarker discovery and cell therapy. Novel automations, high-throughput fraction collectors, and pairing with AI-driven analytics push applications into new territory. All these advances stem from collaboration among product developers, academic users, and regulatory bodies—reflecting both demand and accountability.
Years of using iodixanol in diagnostic imaging built a robust toxicology dataset—most studies report low acute toxicity and minimal mutagenic action at standard concentrations. Oral or parenteral exposure in animals generally leads to mild tissue irritation; only at massive overdoses do kidney or thyroid complications creep up, likely related to iodine load rather than the organic molecule itself. In cell culture, high iodixanol levels can upset delicate cells; that’s why protocols often adjust for osmolality and concentration, thinking less about outright toxicity and more about avoiding edge-case stress. Environmental impact studies remain ongoing, with a focus on fate in water systems and biodegradation. Standard lab use produces levels unlikely to threaten municipal water sources, but responsible disposal helps retain that safety margin.
Looking ahead, the future for density gradients like OptiPrep threads through expanding biological questions—single-organelle sorting, microvesicle profiling from scarce clinical samples, and integration into microfluidics. Researchers already ask whether tweaks to buffer systems could allow sorting of even denser or more fragile particles, or if coupling to fluorescence-activated fractionators could speed up workflows. Advances in AI-driven analysis push for gradients that provide cleaner, more decipherable fractionation, as machine learning algorithms feast on subtle differences missed by the human eye. The spread of cell and gene therapies means every bottleneck in purification gets scrutinized—faster gradients, lower sample loss, easier downstream analytics. Designers test new packaging to reduce plastic waste, improve shelf stability, and keep costs manageable for emerging markets. The next wave of OptiPrep applications will likely blend high-tech instrumentation with traditional bench skills, bringing the molecular separation game into yet more precise and impactful domains.
Step into almost any lab that works with cells or viruses, and you’ll see a bottle of OptiPrep tucked onto a cold shelf. This isn’t some mysterious potion with a fancy label for show—scientists rely on it to keep their experiments honest, especially when separating tiny particles that look alike but do very different jobs.
OptiPrep works as a density gradient medium. Now, in plain language, that means it offers a way to sort things based on how heavy—or dense—each particle is. I’ve tried sorting out cells before, and let me tell you, nothing beats the relief of using a method that doesn’t kill the samples or leave you guessing about purity. OptiPrep’s main component, iodixanol, gives it a slightly higher density than water, so cells and other bits can move up or down in the tube until they settle at a point that matches their own density. That’s about as close to precision as you can get.
In virus research, separating viral particles from cell debris can feel like panning for gold: one wrong step and you’ve lost what you’re after. Before OptiPrep showed up, people tried using sucrose or Percoll. Those are good options, but they come with headaches like harming virus infectivity or making it tough to pull out just the bit you want. In my experience, switching to OptiPrep saved time and frustration—my virus samples looked cleaner under the microscope, which also meant my data made sense.
Beyond viruses, lots of folks use OptiPrep to sort out organelles—the little “rooms” inside cells like nuclei, mitochondria, or lysosomes. Clean prep can mean the difference between finding the protein you’re after or ending up with a soup of mixed leftovers. That came into play for me once when I needed pure mitochondria to study energy production. Other methods left a mess, but OptiPrep kept the mitochondria mostly intact and away from nuclear debris.
Use of OptiPrep lines up with what trustworthy science asks for: accuracy, strong evidence, and transparency. Papers that trace where samples came from and how they were prepared always catch fewer questions in peer review. With a product like this, labs can show their data are built on strong foundations. Even more important, OptiPrep helps experiments use less harsh processing, which keeps cells and viruses as natural as possible. That’s critical for reproducibility, a point scientists stress every day.
Some solvents and gradients can mess with downstream applications by introducing toxins or by-products. OptiPrep shows low toxicity, which means samples can go straight from separation to further testing, including sensitive molecular analyses. This kind of purity also works well for labs worried about animal welfare, since better yield means fewer animals or samples needed for each trial.
If research wants real progress, labs need tools that combine accuracy, safety, and ease-of-use. Products like OptiPrep aren’t flashy, but they fix basic problems: clean separations without harming what you’re after. Still, pricing and availability can get in the way for smaller labs or places outside major research hubs. I’ve seen colleagues turn to homebrew gradients and risk less consistent results. That gap could shrink if manufacturers worked with universities and smaller research groups to make OptiPrep or similar quality products more affordable.
Experience tells me that, for tough separations—whether it’s a rare virus, a tricky organelle, or just cleaner data—OptiPrep delivers on what matters. Trustworthy results start with clean prep, and this density medium supports that every day.
Working in a bioscience lab teaches you quickly that getting pure samples means getting gradients right. OptiPrep isn’t just another solution crowding the fridge—it offers a way to separate cells, organelles, and viruses sharply and with care. These gradients shape the difference between a clean band and a messy smear. Someone once told me you notice the power of a good density medium most on days when your pellet looks like nothing much. You wonder if there’s a shortcut, but you rarely find one.
OptiPrep comes ready to use, a 60% iodixanol solution. For gradient work, stock sits too dense; you need to dilute it. Use a buffer that matches your target sample’s requirements—sometimes just a basic salt solution, sometimes something more complex. Lab folks usually settle somewhere between 6% and 30% for most separations. Always work with cold solutions for better results. If the pipette tip doesn’t touch the bottom of your tube, things can turn inconsistent quickly.
Old school centrifugation protocols often call for step gradients. Here, you gently layer increasing concentrations of diluted OptiPrep in a tube, one on top of the next. Usually, I grip the tube at an angle, and let each new layer climb up the glass wall instead of dropping it straight on top of the last one. The less mixing, the crisper the bands. If you bump the tube, start over.
For continuous gradients, blending the solutions before filling the tube gets you smooth transitions. Some folks use a gradient mixer, but I have made do with two syringes and a three-way valve. Slowly pumping back and forth gives a decent blend if you don’t rush things. Pre-mixing like this avoids the headaches of weak bands.
Setting up gradients isn’t about fancy tricks, but about patience. Always double-check concentrations. Use a refractometer if uncertainty creeps in. Every small miscalculation can shift the outcome, leaving you with an unpredictable separation. In crowded teaching labs, tubes often look alike—always label everything the moment it starts.
Angle matters, both during gradient setup and centrifugation. Swinging-bucket rotors give better separation than fixed-angle rotors, plain and simple. Some protocols cut time by spinning harder or shorter; these cut corners leave you with smeared results that waste more of your afternoon.
If gradients fail, more often than not, it was the pipetting or an unnoticed buffer issue. Practice with food coloring before wasting expensive reagents. Learn to load gently—never dump. If bands look fuzzy, pour slower and check your stock solutions for any cloudiness. Cell types vary in how they behave, so keeping a notebook of your successful concentrations saves headaches on repeat experiments.
In busy research labs, shortcuts get tempting. A solid routine and double-checking each dilution keep things running smoother. Good gradients do half the work in separations; the rest is careful piping and patience.
Experience shapes better habits using OptiPrep. Simple habits—always cold reagents, gentle handling, clear labeling—turn gradient prep from a frustrating task into something manageable and repeatable. Mastering this process grows your lab confidence, and pure bands mean fewer repeats and clearer results when you present your data.
OptiPrep looks pretty technical on the bottle, but breaking down what’s inside tells a practical story. The backbone of this medium is Iodixanol. It's a non-ionic, iodinated compound. The chemical structure brings high water solubility and, crucially, a low osmolality for the concentrations scientists use in cell separation. People working in labs might remember older density gradients like sucrose or Percoll. Iodixanol changed the game in biochemistry. It offers a gentler touch for cells, organelles, and viruses. Unlike some alternatives, it won’t draw water out of samples too harshly or push cells into stressed-out contortions.
Each milliliter of the concentrate hits 60% (w/v) Iodixanol. That’s a heavy gradient solution, way too dense for direct application. Lab workers dilute OptiPrep to fit the specific needs—often for separating blood components, isolating organelles, or purifying viruses. A surprising benefit comes from the near-inertness of Iodixanol; cells and viruses move through it without significant biological disturbance. This means purer fractions and happier samples for later analysis or culture.
OptiPrep includes sodium chloride and phosphate buffer to keep everything friendly for cells. Sodium chloride, at about 0.6%, balances out the solution, mimicking key parts of the body’s own salt content. This gives vulnerable cells a fighting chance to remain healthy, even during long separations. The buffer, disodium hydrogen phosphate (Na2HPO4) at about 5 mM, keeps the pH close to neutral—around 7.2. That’s vital. Skewing too acidic or basic means trouble for anything alive in the sample. A stable pH keeps experimental errors at bay and encourages more repeatable results for everyone involved.
Anyone who’s had to spend hours troubleshooting weird bands in a gradient knows small details in composition translate to big results. The old days of wrangling sugar gradients often led to inconsistent banding or even cell damage. I’ve watched OptiPrep make those headaches less frequent. Researchers can repeat experiments without needing to cross fingers every time. Iodixanol's unique chemistry lets viruses, exosomes, or DNA glide into their own layers, with less threat of clumping or denaturation. It’s not just about getting a sharp band—it’s about keeping sensitive samples in their native state.
Another side to the story comes from safety. Iodixanol doesn’t share the toxicity concerns presented by other gradient media, like cesium chloride. Handling wastes and cleaning up spills doesn’t carry the same risks for teams in the lab, which means less training time and fewer accidents. Sustainable work environments produce better science and less burnout. I’ve seen morale improve just knowing colleagues aren’t facing hazardous material over the long term.
Using OptiPrep still brings challenges. For instance, its higher price can strain tight budgets. Not every lab can absorb the cost without trade-offs elsewhere. Some scientists adapt protocols to use less or recycle fractions where possible. Concentration and storage create another layer of difficulty—solutions must be mixed and handled with precision because the density drops quickly with water addition. Investing in precise pipettes and reliable balances is non-negotiable for good results. Training new team members may take time, but stepwise guides and robust SOPs have helped smooth the learning curve where I’ve worked.
OptiPrep Density Gradient Medium, at its core, brings together iodixanol, sodium chloride, and buffering phosphate. Each part plays a specific role in protecting samples during demanding separations. The clarity and repeatability it offers matter in science, and careful handling ensures each experiment gets the best possible shot at success.
I’ve handled my fair share of cell and molecular biology projects, so it’s normal to run into big decisions about separation media. Colleagues often look at OptiPrep and wonder if this density gradient solution works for their needs. Not every product fits the bill, and sometimes you learn the hard way. It saves time to dig into what makes OptiPrep unique, as well as where it thrives and where it might stumble.
OptiPrep—an iodixanol-based medium—shows up in over 1500 peer-reviewed journals. Researchers love it for isolating virus particles, organelles, plasma membranes, and even exosomes. Unlike sucrose-based solutions, it gives gentle gradients and keeps osmolarity close to what cells are used to. That helps avoid swelling or shrinking artifacts, which can distort downstream data. The published evidence points to solid performance, especially if you want to preserve the biology of delicate samples like mammalian organelles or extracellular vesicles.
Before opening that bottle, figure out how your sample reacts in dense media. Plant cell walls can stand up to a lot, but mammalian cells, especially fragile ones, don’t always handle harsh osmotic changes well. I once tried to purify mitochondria from brain tissue with too-harsh gradients—the mitochondrial yield got clobbered. OptiPrep, with density up to 1.32 g/ml, can be fine-tuned, but misuse strains cell membranes or leaves sticky smears at the centrifuge finish line.
Viral prep? This solution often beats cesium chloride since fewer proteins get denatured and you avoid interfering halides. But if you work with bacteria, you might see clumping due to aggregation in dense iodine-containing environments. It helps to prepare controls and check under the microscope, not just chase absorption readings.
Every prep aims at a final analysis. Maybe it’s electron microscopy, Western blotting, or RNA extraction. OptiPrep leaves out interfering sugars, so spectrophotometry comes easier than with sucrose gradients. I’ve seen students impressed by clean Western blots—less background haze. On the flip side, if you chase ultra-sensitive enzyme assays, tiny traces of iodixanol sometimes interfere. Running mock gradients helps spot those surprises. Enzyme-linked or colorimetric assays occasionally don’t play well with leftover medium. Dialysis, ultrafiltration, or stepwise buffer exchanges keep headaches at bay. Published work from cell biology labs often emphasizes buffer compatibility and meticulous washing; experience backs up that caution.
Sample integrity sometimes trumps all. Some folks save fractions for weeks. OptiPrep stays stable at 2–8°C, but biological specimens require quick, careful handling. If the application calls for storage at -80°C or lower, test a few aliquots with your own protocol. Not every sample behaves well after freeze-thaw cycles with residual iodixanol. I remember seeing EV samples losing vesicle count after cycles, though fresh gradients turned out fine.
Get to know your target. Cell or tissue origin, storage needs, and sensitvity to chemicals all direct the decision. Check the literature, but mix that with hands-on pilot experiments using your own buffers and wash protocols. If things go awry, don’t just blame the medium. Sometimes all it needs is a tweak in gradient layering or a gentler spin. For stubborn targets, talking with researchers who ran similar preps can sidestep weeks of trial and error. If your application isn’t in the usual case studies, those short conversations or quick pilot runs will often keep you moving forward, not stuck troubleshooting yet another failed prep.
Working in the lab, nobody enjoys seeing samples ruined by avoidable mishaps. Few things sting as much as realizing that a bottle of OptiPrep sat out too long or picked up contamination. Over time, even experienced scientists run into problems that trace back to careless handling. Reliable work begins with treating every reagent like a partner in the experiment. Many folks overlook the practical steps that keep a special medium like OptiPrep working as it should.
OptiPrep isn’t like salt or sugar—it needs respect. I learned early that a medium designed for density gradient separation behaves differently if the lab gets sloppy. This solution holds iodixanol, a compound with real sensitivity to air, light, and temperature shifts. I’ve seen a bottle lose effectiveness when someone left it uncapped for an afternoon. Oxygen and carbon dioxide can alter pH and promote breakdown if left unchecked.
Most manufacturers recommend keeping OptiPrep at 2 to 8 degrees Celsius in a refrigerator. Shelves crammed next to solutions with strong odors invite cross-contamination, so always use a clean, designated spot. A tightly capped bottle prevents moisture or vapors from sneaking inside. Every time it’s used, place it straight back into storage instead of leaving it to warm up. Warmth shortens shelf life, and the medium loses its edge. If the lab experiences regular power outages, a backup cooler or generator protects the investment.
Routine can make even the smartest technician cut corners. Before drawing a solution, hands should be clean and dry, gloves fresh, and glassware spotless. One slip-up, and the solution doesn’t just go to waste—future separations will give unreliable results. I saw new staff forget to wipe the bottle neck before pouring, and tiny droplets created sticky build-up. Keeping pour spouts dry reduces risk for fungus or bacterial growth.
Pouring directly from the storage bottle into working tubes drives up the risk of contaminating the main stock. Measuring from a clean intermediate container helps protect the rest. In my experience, the practice of labeling every aliquot with the date and initials stops confusion weeks later about who last used which sample. If you run a shared lab, these habits maintain trust and accountability among team members.
OptiPrep ships out colorless and clear. Cloudiness or dusty particles suggest it’s compromised. I once discovered a faint yellow tint near the bottom of an old bottle, and after investigating, realized improper capping caused oxidation. Colleagues agreed that anything off-color or with floating debris should be tossed, not risked on expensive runs.
Strong odors or separation into layers also give away spoilage, often linked to bacteria. If this shows up, review fridge conditions and reconsider how long bottles sit open during each use. The “just a little longer” attitude shortens the lifespan of every batch.
If logistics make it tough to keep everything cold and capped, plan smaller aliquots for frequent use. Dividing a big bottle into several smaller ones means most of the stock spends less time outside the fridge. Back in school, our advisor insisted on single-use aliquots for sensitive media—less waste, more purity, fewer arguments over who left the bottle out last.
Clear signage and short checklists hung near storage fridges cut down confusion, especially with new staff and visitors. In busy environments, routine reminders keep good habits top-of-mind. Marking inventory regularly helps flag bottles approaching expiration before they meet actual use.
OptiPrep works best when treated with everyday respect, solid routines, and sharp observation. Every lab member holds a piece of responsibility for quality results, so keeping the medium cold, clean, and tightly closed always pays off.
| Names | |
| Preferred IUPAC name | **iodixanol** |
| Other names |
OptiPrep Iodixanol |
| Pronunciation | /ˈɒp.tɪ.prɛp dɪnˈsɪ.ti ˈɡreɪ.di.ənt ˈmiː.di.əm/ |
| Identifiers | |
| CAS Number | 33141-05-0 |
| 3D model (JSmol) | `15-crown-5` |
| Beilstein Reference | 3208735 |
| ChEBI | CHEBI:88273 |
| ChEMBL | CHEMBL1356 |
| ChemSpider | 728452 |
| DrugBank | DB14441 |
| ECHA InfoCard | ECHA InfoCard: 03fa4d73-9ad9-4a85-b36b-06e52e42e2d2 |
| EC Number | 000000004195870322 |
| Gmelin Reference | 60795 |
| KEGG | C00720 |
| MeSH | D020841 |
| PubChem CID | 446105 |
| RTECS number | QJ6950000 |
| UNII | DZB36S888V |
| UN number | UN3142 |
| Properties | |
| Chemical formula | C6H10O6 |
| Molar mass | 1.32 g/ml |
| Appearance | Clear, colorless liquid |
| Odor | Odorless |
| Density | 1.320 g/mL |
| Solubility in water | Soluble in water |
| log P | 7.2 |
| Vapor pressure | <0.01 hPa at 20 °C |
| Acidity (pKa) | 7.2 |
| Basicity (pKb) | 7.6 |
| Magnetic susceptibility (χ) | -11.0 × 10⁻⁶ (cgs units) |
| Refractive index (nD) | 1.320 |
| Viscosity | 1.320 mPas |
| Dipole moment | 0.02 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 690.0 J·mol⁻¹·K⁻¹ |
| Pharmacology | |
| ATC code | V08AD09 |
| Hazards | |
| Main hazards | Harmful if swallowed or inhaled. Causes serious eye irritation. Causes skin irritation. |
| GHS labelling | GHS07; GHS08; Warning; H315, H319, H335, H361 |
| Pictograms | GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H319: Causes serious eye irritation. |
| Precautionary statements | May cause damage to organs through prolonged or repeated exposure. Wash skin thoroughly after handling. Do not breathe mist/vapours/spray. Get medical advice/attention if you feel unwell. |
| NFPA 704 (fire diamond) | NFPA 704: 1-1-0 |
| Flash point | No flash point |
| Lethal dose or concentration | LD₅₀ (oral, rat): >8000 mg/kg |
| LD50 (median dose) | LD50 (oral, rat): >5,000 mg/kg |
| PEL (Permissible) | Not established. |
| REL (Recommended) | 60% (w/v) solution of iodixanol in water |
| Related compounds | |
| Related compounds |
Nycodenz Iodixanol |
