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Product Name: Oligonucleotide, Synthetic DNA/RNA
Chemical Family: Nucleic acids
Product Use: Research, Diagnostics
Chemical Formula: Variable sequence of deoxyribonucleotides or ribonucleotides
Manufacturer: Provided upon request
Synonyms: Oligos, Primers, Probes
Contact Information: Refer to supplier's resources
Emergency Contact: Refer to supplier's emergency number
Classification: Not classified as hazardous under GHS
Appearance: White or off-white solid, lyophilized powder, or aqueous solution
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Acute Health Hazards: Unlikely to pose risk in normal laboratory use; dust can cause mild irritation to eyes and respiratory tract
Chronic Health Hazards: No known chronic hazards from standard exposure
Environmental Hazards: Not expected to be harmful to aquatic environments at anticipated quantities used
Warning: Handle as if potentially infectious when of biological origin or when labeled with hazardous moieties
Component: Synthetic oligonucleotide
Chemical Name: Variable sequence DNA/RNA
CAS Number: Not assigned (sequence-dependent)
Concentration: 100% in lyophilized powder; varies in solution
Additives: May contain buffer salts (e.g., sodium, potassium phosphate), stabilizing agents
Purity: Typically >90% by mass, varies depending on synthesis and purification
Contaminants: Trace organic solvents or acrylamide possible depending on purification
Inhalation: Move person to fresh air. Seek medical attention if symptoms develop.
Skin Contact: Wash skin with soap and water. Remove contaminated clothing and wash before reuse.
Eye Contact: Rinse eyes cautiously with water for at least 15 minutes. Seek medical attention if irritation persists.
Ingestion: Rinse mouth with water. Seek medical advice if feeling unwell.
Most Important Symptoms: Irritation, redness, coughing
Note to Physician: No specific antidote known; treat based on symptoms
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: Not determined for small quantities
Specific Hazards: Emits carbon oxides, nitrogen oxides, phosphorus oxides under fire conditions
Protective Equipment: Wear self-contained breathing apparatus and protective clothing
Firefighting Instructions: Avoid inhalation of fumes. Use measures suitable for surrounding fire.
Personal Precautions: Avoid dust generation, wear appropriate PPE, avoid contact with skin, eyes, and clothing
Environmental Precautions: Prevent material from entering drains, soil, or waterway systems
Cleanup Methods: Sweep or scoop up using gentle methods to avoid dust; wipe surfaces using wet cloth; dispose of solid and liquid waste in accordance with local regulations
Spill Response: Ventilate area, avoid breathing dust, and follow laboratory waste protocols for disposal
Safe Handling: Handle in accordance with good laboratory hygiene and safety practices; avoid inhalation, ingestion, and contact with skin and eyes; do not eat, drink, or smoke during use
Technical Measures: Use in well-ventilated area; employ dust control if powder present
Storage Conditions: Store tightly closed in original container at recommended temperature (commonly –20°C for long-term); avoid light and moisture
Incompatible Materials: Strong oxidizers, acids, bases
Storage Stability: Stable under recommended conditions
Exposure Limits: No established occupational exposure limits
Engineering Controls: Use appropriate local exhaust ventilation
Personal Protective Equipment (PPE): Laboratory coat, gloves, safety glasses or goggles
Respiratory Protection: Not required under normal laboratory use; use respirator during powder handling, large-scale processes, or spill cleanup
Other Equipment: Eye wash station and safety shower accessible
Hygiene Measures: Wash hands after handling, remove protective equipment before leaving lab area
Appearance: White or off-white lyophilized powder, occasionally as a clear, colorless solution
Odor: Odorless
Odor Threshold: Not applicable
pH: Typically near neutral (solution dependent)
Melting Point/Range: Not well defined; degradation starts >160°C
Boiling Point: Decomposes
Flash Point: Not available
Solubility: Readily soluble in water
Vapor Pressure: Not relevant
Partition Coefficient (n-octanol/water): Not determined
Relative Density: Variable, not typically measured
Viscosity: Not relevant for powder form
Explosive Properties: Not explosive under standard lab conditions
Oxidizing Properties: No oxidizing properties
Chemical Stability: Stable when stored at –20°C and protected from light and moisture
Reactivity: Non-reactive under normal laboratory conditions
Conditions to Avoid: Prolonged exposure to air, moisture, heat, direct sunlight
Incompatible Materials: Oxidizers, acids, bases, strong reducing agents
Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides, phosphorus oxides
Hazardous Polymerization: Will not occur
Shelf Life: Several months to years, sequence and modification dependent
Acute Toxicity: Not acutely toxic via oral, inhalation, or dermal routes in standard lab use
Chronic Toxicity: No data for chronic exposure; classified as low hazard due to degradation by body enzymes and environmental microbes
Mutagenicity: Not expected, but may depend on modifications or chemical tags
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, OSHA, or ACGIH
Reproductive Toxicity: No experimental data; not anticipated based on chemical nature
Specific Target Organ Toxicity: No evidence for specific organ toxicity
Other Information: Nucleoside analog modification or labeling with hazardous moieties may require separate risk assessment
Aquatic Toxicity: Not expected to harm aquatic life at typical use concentrations
Biodegradability: Rapidly degraded in environment due to nuclease activity; rapidly broken down to nucleotides and subsequently to inorganic minerals
Bioaccumulation Potential: Low potential, as products are normal metabolites
Soil Mobility: High solubility increases movement in water systems, but short environmental persistence
Ecotoxicological Data: No specific data; similar biomolecules have minimal ecological effects
Waste Disposal Methods: Dispose via chemical waste procedures or drain after ensuring compatibility with local, regional, and national regulations
Contaminated Packaging: Dispose of empty containers as laboratory waste
Special Precautions: Avoid introducing to drains in large quantities; consult local environmental agency if unsure
Disposal of Modified/Oligonucleotides with Tags: Assess tagging chemicals (e.g., fluorescent dyes, radioactive labels) for their own disposal requirements
UN Number: Not regulated as dangerous good for transport
Proper Shipping Name: Non-hazardous for transport
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Label Requirements: No special labeling necessary under normal conditions
Special Transport Precautions: Shield from extreme temperatures, avoid rough handling, keep tightly sealed
OSHA Hazard Communication Status: Exempt as non-hazardous chemical
TSCA Status: Listed, as nucleic acids are exempt from reporting
SARA Title III Information: Not listed as hazardous under Sections 302, 304, 311, 312 or 313
California Proposition 65: Not listed
REACH Annex XIV: Not listed
Canadian WHMIS Classification: Not controlled
Other National, State or Local Regulations: Subject to regulations covering genetically modified or synthetic DNA sequences in some jurisdictions; confirm local requirements for oligonucleotides with unique modifications or organismal origins
