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Product Name: Novobiocin Sodium
Chemical Name: Sodium 4-[(2R,3R,4S,6R)-3,4-dihydroxy-2-((1S)-1-hydroxyethyl)-5,6-dimethoxyoxan-6-yl]-3-hydroxy-1,4-dioxo-1,4-dihydroquinoline-2-carboxylate
CAS Number: 1476-53-5
Recommended Use: Laboratory research, antibiotic agent
Supplier Details: Manufacturer and distributor contact details vary by country; always refer to the invoice or packaging for urgent communication.
Emergency Contact: Refer to national chemical emergency lines and poison control resources.
GHS Hazard Classification: Acute toxicity (oral, inhalation, dermal); Health hazard for sensitive individuals
Signal Word: Warning
Hazard Statements: May cause allergic skin reaction; Harmful if swallowed or inhaled; May cause irritation to the eyes, skin, and respiratory tract
Precautionary Statements: Avoid breathing dust or aerosols, wear protective gear, seek fresh air if symptoms develop
Physical Hazards: Fine powder can form combustible dust concentrations in air under rare circumstances
Human Health Hazards: Prolonged exposure to high concentrations may harm liver and kidneys, complicate pre-existing conditions
Label Elements: Exclamation mark, health hazard pictogram, and appropriate signal wording required on containers
Chemical Identity: Novobiocin Sodium
Synonyms: Sodium Novobiocinate
Purity: Typically >95% active ingredient
Ingredients: Novobiocin Sodium (active), minor amounts of water of crystallization, trace byproducts from synthesis (hydrolyzed impurities)
Molecular Formula: C31H35N2NaO11
Molecular Weight: 634.62 g/mol
Inhalation: Move the person to fresh air, support breathing as needed, seek medical attention for persistent cough or shortness of breath
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water; if irritation persists, consult a physician
Eye Contact: Rinse eyes with plenty of water for several minutes; remove contact lenses if easily possible, continue rinsing, get medical help if discomfort continues
Ingestion: Rinse mouth if possible, avoid inducing vomiting unless directed by a medical professional, provide water if the victim is conscious, seek immediate medical care
Symptoms/Effects: Dizziness, headache, rash, gastrointestinal upset, difficulty breathing in severe reactions
Suitable Extinguishing Media: Dry chemical, CO₂, alcohol-resistant foam, or water spray
Unsuitable Extinguishing Media: High-pressure water jets can disperse powder
Hazardous Combustion Products: Toxic fumes including carbon oxides, nitrogen oxides, and sodium compounds
Protective Equipment: Firefighters should use self-contained breathing apparatus and full protective clothing
Fire/Explosion Risk: Dust may form explosive mixtures with air, avoid accumulation of dust near ignition sources
Personal Precautions: Wear protective gloves, goggles, and mask to prevent inhalation and skin contact
Environmental Precautions: Avoid discharge into drains, surface water, or soil, contain spill using barriers
Spill Cleanup Methods: Collect spilled material mechanically, place in a secure, closed container, ventilate the area, clean surfaces with damp cloth, avoid dry sweeping, dispose according to local regulations
Notification: Report significant releases to local environmental authorities where required
Handling: Operate in well-ventilated conditions, minimize generation of dust and aerosols, avoid contact with skin, eyes, and clothing, use suitable personal protective equipment (PPE), wash hands after handling, never eat, drink, or smoke in processing areas
Storage: Store in a tightly closed, labeled container at 2-8°C, away from light, moisture, and incompatible chemicals like strong oxidizing agents, acids, or bases, keep out of reach of unauthorized personnel, secure from unintentional use
Special Precautions: Follow institutional policies for handling bioactive compounds, maintain inventory records for safety
Control Parameters: No established occupational exposure limits (OELs / PELs) for novobiocin sodium; observe general laboratory hygiene standards
Engineering Controls: Use local exhaust ventilation, chemical fume hoods, or containment enclosures for powder handling
Personal Protection: Safety goggles or face shield, chemical-resistant gloves (nitrile or neoprene), lab coat or disposable gown, NIOSH-certified respirator if dust becomes airborne above background
Hygiene Measures: Change contaminated clothing promptly, wash hands and face before breaks and at the end of work, do not reuse contaminated PPE
Appearance: White to pale yellow crystalline powder
Odor: Odorless or slight organic scent
pH: Aqueous solution pH near 7-9
Solubility: Soluble in water, sparingly soluble in organic solvents
Melting Point: Decomposes before melting, usually above 200°C
Boiling Point: Not applicable (decomposes)
Vapor Pressure: Negligible at ambient conditions
Density: Approximately 1.3 g/cm³
Flash Point: Not determined
Other Properties: Sensitive to prolonged light and elevated temperature, stable only under dry, cool, dark storage
Chemical Stability: Stable in original, closed packaging under recommended conditions; may degrade if exposed to heat, moisture, or prolonged light
Incompatible Materials: Strong oxidizers, strong acids and bases
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides, and sodium oxides may form under fire or decomposition
Hazardous Reactions: No hazardous polymerization expected, avoids unintended reactions by controlling environment and segregating incompatible substances
Conditions to Avoid: Excess heat, exposure to light, prolonged air exposure, sources of ignition for dust
Acute Toxicity: Data for rodents give LD₅₀ (oral, rat) around 3000 mg/kg; significant effects in higher doses include gastrointestinal irritation, CNS effects
Chronic Toxicity: Not fully studied in humans, but possible cumulative toxicity in prolonged lab exposures
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Symptoms: Headache, nausea, allergic skin reactions, itching, respiratory discomfort, rare but serious liver and kidney impacts in sensitive individuals
Sensitization: May induce allergic response on repeated or prolonged contact
Carcinogenicity/Mutagenicity: No comprehensive studies proving cancer or mutagen risk; handle as a compound of unknown chronic toxicity
Aquatic Toxicity: Harmful to aquatic organisms in large spills, may disrupt microbes or invertebrates in water systems
Persistence and Degradability: Moderately persistent under natural sunlight; biological degradation can occur, but the rate is slow
Bioaccumulative Potential: Low to moderate, not expected to bioconcentrate based on physicochemical properties
Mobility in Soil: Moderate water solubility can facilitate transport in soil; may reach groundwater if released in significant quantity
Other Hazards: High concentrations in effluent or waste streams pose risk to sewage and water treatment microbes; contain and minimize entry into natural water courses
Waste Treatment Methods: Collect waste in tightly sealed, clearly labeled containers, degenerate chemically if local law allows, incinerate at a licensed facility or dispose via approved chemical collection
Contaminated Packaging: Dispose as hazardous waste, triple rinse before recycling if permitted, deface or remove labels before discarding packaging
General Notes: Never allow drainage into household sewage, local environmental and health regulations apply, coordinate with institutional biosafety and hazardous waste programs
UN Number: Not classified as a dangerous good by ADR, RID, IMDG, or IATA
Hazard Class: Non-regulated in small research volumes
Packing Group: Not applicable
Transport Labels: Standard chemical label with product name and hazard warnings
Special Precautions: Protect containers from breakage or spillage during shipment, follow institutional or national protocols for bioactive pharmaceuticals
Further Recommendations: Carry transport documentation declaring nature and amount of material, comply with national security controls for transport of pharmacologically active substances
Labelling: Compliant with GHS/CLP requirements for hazardous chemical labelling
Regulatory Status: May be listed in national or international chemical inventories; use subject to local authorization for pharmaceutical and laboratory applications
REACH: Not registered for broad commercial use under REACH; research use limitations apply in the European Union
TSCA: Not listed for non-research use in the United States
Other Regulation: Always refer to most current local health, safety, and environmental protection regulation for laboratory agents
Workplace Safety: Institutional or national chemical safety legislation governs use, handling, and training requirements
