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Product Name: N,O-Bis(trimethylsilyl)trifluoroacetamide
Synonyms: BSTFA
CAS Number: 25561-30-2
Recommended Use: Silylation reagent typically in analytical chemistry, especially GC derivatization
Supplier: Laboratory chemical distributors
Contact Information: Emergency telephone numbers for local poison control or company-specific safety resource
Chemical Formula: C8H18F3NOSi2
GHS Classification: Flammable liquid (Category 2), Acute toxicity, skin or eye irritant
Hazard Symbols: Flame, Exclamation mark
Signal Word: Danger
Hazard Statements: Flammable liquid and vapor; causes skin and eye irritation; harmful if swallowed, inhaled, or comes into contact with skin
Precautionary Statements: Keep away from heat, sparks, open flames; use proper personal protective gear; avoid breathing vapors; wash hands after handling; use outdoors or in a well-ventilated area
Potential Health Effects: Inhalation brings respiratory tract irritation, headache, and dizziness. Skin and eye contact bring burns or irritation. Ingestion leads to stomach pain or more serious systemic effects.
Chemical Name: N,O-Bis(trimethylsilyl)trifluoroacetamide
CAS Number: 25561-30-2
Concentration: ≥ 98%
Impurities: Trace amounts of trimethylsilyl derivatives and solvents may be present due to regular production methods
Inhalation: Move to fresh air, seek medical attention for trouble breathing, persistent cough, or dizziness
Skin Contact: Rinse with plenty of water and remove contaminated clothing; for persistent skin reaction, get quick medical attention
Eye Contact: Rinse immediately with clean water, keeping eyelids open; if irritation remains or vision changes, go directly to emergency care
Ingestion: Do not induce vomiting; rinse mouth with water; seek medical advice promptly and share product information
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, alcohol-resistant foam
Unsuitable Media: Water jets could spread the burning liquid
Specific Hazards: Releases toxic fumes of carbon oxides, nitrogen oxides, silicon oxides, and hydrogen fluoride when burning
Protective Equipment: Firefighters use self-contained breathing apparatus and full protective clothing
Special Procedures: Remove non-involved persons away from fire area; cool exposed containers with water spray from a safe distance
Personal Precautions: Ventilate area to prevent vapor build-up, use chemical-resistant gloves and splash goggles
Spill Cleanup: Contain spill with inert absorbent material, such as sand, avoid allowing to enter drains, place waste in proper container for disposal
Environmental Precautions: Prevent run-off into surface waters, sewers, and confined spaces
Decontamination: Wash down residue with large amount of water and detergent, avoid direct contact with skin or eyes
Handling: Use only with adequate ventilation, avoid all personal contact by wearing gloves and eye protection, vapor forms quickly above room temperature, so seal containers tightly after use
Storage: Store in cool, dry, properly vented area; keep away from heat, sparks, and sources of ignition; segregate from acids, water, oxidizers, and moisture-sensitive chemicals; use original packaging or chemically compatible containers
Container Requirements: tightly sealed glass or high purity plastic, labeled clearly with chemical name and hazard information
Engineering Controls: Use chemical fume hood or local exhaust ventilation
Respiratory Protection: In poorly ventilated areas, wear organic vapor respirator
Skin Protection: Laboratory-grade nitrile gloves, chemical-resistant lab coat or apron
Eye Protection: Chemical splash goggles or face shield
Hygiene Practices: Wash hands thoroughly after use, remove contaminated garments and wash before reuse, no eating or drinking in work area
Exposure Limits: No occupational exposure limits established by OSHA, ACGIH, NIOSH for BSTFA, but standard chemical handling protocols apply
Appearance: Clear, colorless to pale yellow liquid
Odor: Pungent, irritating
Boiling Point: 140‒142°C
Melting Point: Not determined, liquid at room temperature
Flash Point: About 33°C (91°F), closed cup
Autoignition Temperature: Not documented, estimated above 200°C
Explosive Limits: Not established for BSTFA
Vapor Pressure: Moderate, increases rapidly above room temperature
Density: Approximately 1.22 g/cm³
Solubility in Water: Reacts with water, decomposes
Partition Coefficient (n-octanol/water): Not measured
Evaporation Rate: Rapid, volatile at room temperature
pH: Not applicable, hydrolyzes in water producing acids
Chemical Stability: Sensitive to moisture, hydrolyzes in the presence of water
Reactivity: Forms acids and silanols when exposed to water or alcohols
Conditions to Avoid: Moisture, high humidity, sources of ignition, direct sunlight
Incompatible Materials: Water, acids, strong oxidizing agents, bases
Hazardous Decomposition Products: Hydrogen fluoride, carbon oxides, silicon oxides, ammonia, trimethylsilanol vapors on breakdown
Polymerization: Will not occur under normal conditions
Acute Toxicity: LD50 (oral, rat) not available but considered moderate based on similar compounds
Skin Corrosion/Irritation: Irritation, redness, burns may occur on contact
Serious Eye Damage/Irritation: Severe burns and possible permanent injury possible
Respiratory Sensitization: Irritation to nose, throat, lungs with regular exposure; dizziness, headache possible after high exposure
Carcinogenicity: No data suggesting carcinogenicity, not listed by NTP, OSHA, or IARC
Mutagenicity: No in vitro or in vivo evidence
Other Information: Allergic skin reactions possible in sensitized individuals
Aquatic Toxicity: Limited direct data; based on hydrolysis and breakdown, can lead to release of trifluoroacetic acid and silicon-containing waste, which may impact aquatic organisms if entering waterways
Persistence and Degradability: Undergoes rapid hydrolysis in the environment to form potentially persistent breakdown products
Bioaccumulative Potential: Unlikely due to rapid breakdown in water
Mobility in Soil: Highly mobile as a liquid; breakdown products migrate rapidly, particularly trifluoroacetic acid
Other Adverse Effects: General caution with any trifluorinated organic; avoid unintentional release to natural habitats
Disposal Methods: Dispose of as hazardous organic waste; can require incineration at approved facility; do not dispose with household waste or down drains
Containers: Triple-rinse empty containers with a suitable solvent, then destroy beyond reuse or recycle with hazardous chemical waste handlers
Precautions for Disposal: Neutralize and absorb spills, prevent runoff to water; keep detailed records of waste disposal in compliance with local, state, and federal law
Discharge to Environment: Strictly avoid; release to the environment threatens water and soil quality
UN Number: UN 1993
Proper Shipping Name: Flammable Liquid, N.O.S. (contains N,O-Bis(trimethylsilyl)trifluoroacetamide)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: II
Labeling: Flammable liquid marking, appropriate risk labeling per shipping regulations
Special Precautions: Secure packaging to protect against breakage and leaks; communicate contents clearly on shipping manifest; comply with regional safety transport guidelines
Environmental Hazards: Marine pollutant classification not assigned, but spills can cause environmental harm
Transport in Bulk: Not intended for bulk transport
US TSCA Status: Listed
EU REACH Status: Registered or pre-registered, check with supplier for updated status
OSHA Status: Regulated as hazardous due to flammability and acute toxicity
SARA 313/302: Not specifically listed as a reportable chemical under SARA Title III
California Proposition 65: Not classified to contain known carcinogens or reproductive hazards
WHMIS (Canada): Class B2 (Flammable Liquid), D2B (Toxic Material causing other toxic effects)
Other Regulations: Handle under chemical laboratory safety protocols, maintain safety documentation, provide training to all staff working with or exposed to BSTFA
