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Chemical Name: N,O-Bis(trimethylsilyl)acetamide
Common Synonyms: BSA, N,O-bis(trimethylsilyl)acetamide
Chemical Formula: C8H21NOSi2
CAS Number: 10416-59-8
Physical Form: Clear to pale yellowish liquid, distinct ammonia-like odor
Uses: Mainstay reagent in organic synthesis, especially for silylation of alcohols, amines, acids
GHS Classification: Flammable liquid, skin irritant, eye irritant
Hazard Symbols: Flame, exclamation mark
Health Effects: Skin contact irritates and may cause redness or burning sensation, vapor may sting eyes and upper airway, swallowing brings nausea or stomach upset.
Fire Risk: Vapors ignite readily, especially near open flames or static discharge.
Chronic Effects: No known chronic toxicity reports, but repeated over-exposure could worsen respiratory or skin conditions.
Environmental Concerns: Spills threaten aquatic life if not contained quickly.
Primary Component: N,O-Bis(trimethylsilyl)acetamide >97%
Impurities: Trace organosilicon byproducts,
Stabilizers: Rarely used, unless storing for lengthy periods
Inhalation: Remove to fresh air, support breathing if trouble starts, medical help needed for lingering cough or trouble breathing.
Skin Contact: Wash with gentle soap and water. Take off contaminated clothing. See a doctor for rash or persistent itching.
Eye Contact: Rinse with plenty of water, keeping eyelid open. Hold for up to 15 minutes. Follow up with a doctor.
Ingestion: Rinse mouth, don’t force vomiting. Seek prompt medical help if feeling sick or disoriented.
Extinguishing Media: Alcohol-resistant foam, dry chemical powder, or CO2.
Don’ts: Avoid water jet, can spread fire.
Special Equipment: Firefighters bank on self-contained breathing apparatus and full turnout gear.
Special Hazards: Burning releases toxic fumes (carbon oxides and silicon oxides), and possibly explosive vapors.
Advice in Case of Fire: Move containers away from fire area if safe. Cool with water mist, not stream.
Personal Precautions: Suit up with gloves, goggles, apron. Avoid contact with skin or eyes.
Environmental Protections: Stop leaks to drains, soil, or waterways. Use absorbent inert material like sand for small spills.
Cleanup Procedures: Ventilate affected area. Collect and shovel up for proper disposal in sealable containers.
Handling: Work under ventilation, keep from open flames or sparks, don’t eat or drink nearby. Use only properly grounded equipment.
Storage: Keep tightly closed and away from incompatible materials (acids, oxidizers, moisture). Store below 25°C in a dry, dark space.
Personal Protective Equipment (PPE): Chemical goggles, nitrile gloves, lab coats, fume hood for any open work.
Engineering Controls: Local exhaust ventilation cuts vapor build-up.
Workplace Hygiene: Wash hands after use, don’t reuse contaminated gear, avoid breathing vapor, keep eyewash stations nearby.
Appearance: Colorless to light yellow liquid
Odor: Ammonia-like
Boiling Point: 157°C
Melting Point: <-40°C
Flash Point: 45 to 54°C (closed cup)
Vapor Pressure: Moderate at room temperature
Solubility: Reacts with water, soluble in many organic solvents
Density: About 0.89 g/cm³ at 25°C
Chemical Stability: Stable if dry and sealed.
Hazardous Reactions: Hydrolyzes rapidly in water, especially acidic or basic conditions.
Incompatibles: Strong acids, oxidizers, moisture.
Hazardous Decomposition: Produces toxic silicon, carbon, and nitrogen oxides in fire.
Acute Toxicity: Low-to-moderate acute oral toxicity reported. Skin or eye exposure leads to immediate irritation.
Long-term Exposure: Could cause dermatitis on repeated, unprotected handling, no strong evidence for chronic organ damage.
Sensitization: No strong evidence for airway or contact sensitization, though limited data comes from industrial settings.
Carcinogenicity: Not listed on common carcinogen lists.
Acute Risk to Aquatic Life: Liquid runoff harms aquatic organisms, especially in bulk spills.
Degradability: Hydrolyzes to volatile siloxane compounds in soil and water, breaks down over weeks.
Bioaccumulation: Unlikely based on structure, though persistent in anaerobic wetland environments.
Preferred Methods: Incinerate in a licensed facility after mixing with combustible solvent.
Landfill Suitability: Not recommended due to breakdown risk and potential leaching.
Container Disposal: Rinse with compatible solvent before recycling drums, always check with local hazardous waste authority.
UN Number: Commonly shipped as a flammable liquid in regulated packages.
Packing Group: Usually Group III due to moderate hazard.
Transport Labels: Flammable liquid label required.
Precautions: Protect from heat, shock, and rough handling. Emergency information must travel with the chemical.
Labeling Requirements: Flammable, irritant – OSHA, GHS standards apply.
Inventory Status: Registered substances under TSCA in the United States and similar registers in the EU and Japan.
Workplace Controls: Regular review of exposure plans, up-to-date MSDS in work zones, periodic PPE checks.
Discharge Limits: National and local water discharge limits apply, especially for sizable spills or waste streams.
