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Product Name: N,N-Diisopropylethylamine
Synonyms: DIPEA, Hünig’s base, DIPE
Chemical Formula: C8H19N
Molecular Weight: 129.25 g/mol
CAS Number: 7087-68-5
Recommended Use: Used as a base in organic synthesis, especially for amide and ester formation, alkylations, peptide coupling, and as a proton scavenger
Supplier Information: Contact details listed on original packaging or obtain from purchasing department
Emergency Contact: Refer to local/national poison control or chemical emergency resources
Classification (GHS): Flammable liquid (Category 3); Acute toxicity, oral (Category 4); Acute toxicity, dermal (Category 4); Skin corrosion/irritation (Category 2); Serious eye irritation (Category 2A)
Signal Word: Warning
Hazard Statements: Causes skin and serious eye irritation; Harmful if swallowed or if absorbed through the skin; Flammable liquid and vapor; May cause respiratory irritation
Pictograms: Flame, Exclamation Mark
Precautionary Statements: Avoid breathing vapors; Wear protective gloves, eye protection, and suitable clothing; Keep away from sparks/open flames and hot surfaces; If on skin: wash with plenty of water; If inhaled: Move to fresh air
Substance: N,N-Diisopropylethylamine
Chemical Identity: 100% by weight
Impurities or Additives: No significant impurities known from commercial suppliers, check batch-specific certification if strict purity is needed for process or research protocol
General Advice: Assess victim for vital signs and alert emergency responders as appropriate
Inhalation: Remove individual to fresh air; keep at rest; monitor for difficulty breathing; seek medical attention if symptoms persist or escalate
Skin Contact: Remove contaminated clothing and rinse affected area with running water for at least 15 minutes; seek medical evaluation for persistent irritation
Eye Contact: Promptly rinse eyes with lukewarm running water, holding eyelids apart, for a minimum of 15 minutes; urgent medical assessment advised
Ingestion: Rinse mouth; do not induce vomiting; immediately call a poison center or physician for further guidance
Suitable Extinguishing Media: Use dry chemical powder, carbon dioxide, or foam; do not use water jets directly
Specific Hazards: Can form irritating and toxic gases (including nitrogen oxides) upon combustion; vapors may travel and ignite back to source; containers exposed to fire risk violent rupture due to pressure build-up
Special Protective Equipment: Firefighters should use self-contained breathing apparatus and full fire-resistant clothing
Advice for Firefighters: Remove all persons from area, fight fire from upwind, prevent runoff to sewers or natural waterways, cool fire-exposed containers with water spray from a safe distance
Personal Precautions: Evacuate area of non-essential personnel; ventilate; eliminate all ignition sources; wear chemical splash goggles, rubber gloves, and an approved respirator if exposure risk is high
Environmental Precautions: Prevent spillage from reaching soil, groundwater, or storm drains; notify environmental authorities per local requirements
Methods for Containment and Clean-Up: Confine spill with inert absorbent (sand, vermiculite); collect residue for proper disposal inside labeled, sealed containers; clean area with detergent and water; do not allow wash water to enter drainage
Reference to Other Sections: See sections on personal protective equipment and disposal
Safe Handling Practices: Ground and bond containers during transfer; work in chemical fume hood; keep container tightly closed; avoid direct contact with eyes, skin, and clothing; use only non-sparking tools
Storage Conditions: Store in tightly sealed original container, in cool, well-ventilated location, away from heat, sparks, and sources of ignition; segregate from oxidizers, acids, acid chlorides, and strong alkylating agents
Technical Measures: Static electricity preventive measures needed for bulk processing; maintain chemical-resistant secondary containment
Incompatibilities: Avoid contact with strong acids, oxidizers, acid chlorides, and halogens due to risk of violent reaction
Occupational Exposure Limits: No established ACGIH, OSHA, or EU occupational exposure limits; handle as hazardous material
Engineering Controls: Use local exhaust ventilation or chemical fume hood; maintain eyewash and safety shower within the vicinity
Personal Protective Equipment:
- Eye/Face: Chemical splash goggles or face shield
- Hand: Nitrile or butyl rubber gloves
- Skin/Body: Laboratory coat, closed shoes, chemical-resistant apron where splash risk exists
- Respiratory: NIOSH-approved organic vapor respirator for extended operations or high vapor concentrations
Hygiene Tips: Wash hands before eating, drinking, or leaving work area; remove contaminated clothing and wash before reuse
Appearance: Clear, colorless to pale yellow liquid, distinct amine odor
Boiling Point: 127–129°C (pressure-dependent)
Melting Point: -56°C
Flash Point: 30–37°C (closed cup)
Flammability: Flammable liquid
Vapor Pressure: 4.4 hPa at 20°C
Solubility: Miscible with most organic solvents; slightly soluble in water
Density: 0.742 g/mL (20°C)
pH: Basic; strongly alkaline, will saponify many organic acids
Partition Coefficient (Log Pow): ~2.4
Viscosity: Mobile liquid, low viscosity
Auto-Ignition Temperature: Approx. 215°C
Explosive Limits: Lower 1.3% / Upper 7.2% (v/v in air)
Chemical Stability: Stable under normal storage and handled conditions
Reactivity: Reacts vigorously with strong acids and acid chlorides, forming toxic gases; reacts with strong oxidizing agents; reacts exothermically with water under some conditions
Possibility of Hazardous Reactions: Exothermic reactions with halogenated compounds and acid derivatives
Hazardous Decomposition Products: Nitrogen oxides, nitrogen hydrides, and possible carbon oxides on incineration
Conditions to Avoid: Heat, open flames, incompatible materials, extended air exposure that may cause peroxide formation
Acute Toxicity: Oral (rat) LD50 ~ 870 mg/kg; Dermal (rabbit) LD50 ~ 1100 mg/kg; likely to cause adverse effects if ingested, inhaled, or absorbed through skin
Irritation: Skin, respiratory tract, and eyes suffer moderate to severe irritation
Sensitization: Not classified as a sensitizer under standard protocols
Long-Term Exposure: Prolonged or repeated contact may lead to dermatitis or defatting
Carcinogenicity/Mutagenicity/Teratogenicity: No reliable animal or epidemiological evidence pointing to cancer, gene, or developmental toxicity at current exposure limits
Symptoms of Overexposure: Burning sensation, coughing, headache, nausea, dizziness, possible CNS effects in severe cases requiring urgent evaluation
Acute Aquatic Toxicity: Toxic to aquatic life; LC50 (fish, 96hr): 10–100 mg/L
Persistence and Degradability: Moderately biodegradable in aquatic environments, supports microbial breakdown under aerobic conditions
Bioaccumulation: Limited potential for significant accumulation in aquatic organisms
Mobility in Soil: Mobile in water; volatility and binding to soil moderately probable under spill circumstances
Other Adverse Effects: Do not release large quantities to surface waters or sewer systems; toxic to algae and invertebrates at high concentrations
Disposal Methods: Dispose via licensed chemical waste contractor familiar with hazardous organic amines
Empty Containers: Containers that held this material should not be repurposed; triple rinse with proper solvent, clean residue according to local waste procedures
Regulations: Comply with federal, state, and local regulations for hazardous organic chemicals; never discharge in drains or surface water
UN Number: 1158
UN Shipping Name: Diisopropylethylamine
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: II
Labels: Flammable liquid
Marine Pollutant: Yes, if shipped in large quantities
Special Precautions for User: Pack tightly sealed, secondary container, upright, away from acids and oxidizers; mandatory documentation for shipping
Inventory Listings: Listed on TSCA (USA), EINECS (EU), DSL (Canada), AICS (Australia), among other national inventories
Regulatory Requirements: Subject to workplace hazardous chemical regulations; strict labeling and training required; compliance with local occupational exposure standards critical
REACH Status: Registered under EU REACH as intermediate and substance
SARA Title III (USA): Not listed as extremely hazardous or toxic chemical; incidental entries under flammable hazard requirements
Other Regulations: Local fire codes, chemical storage, and wastewater discharge rules apply; always refer to up-to-date sources from local health and safety bodies
