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Chemical Name: N-Hippuryl-His-Leu Hydrate
Chemical Class: Dipeptide substrate for enzyme assays
Common Use: Substrate in biochemical research, especially for studying angiotensin-converting enzyme activity
Description: White to off-white powder that dissolves in water; often handled inside labs focusing on molecular biology or clinical biochemistry
GHS Classification: Not classified as hazardous under typical research laboratory standards.
Health Hazards: Powder can irritate eyes, skin, and upper respiratory tract if handled without care. Potential for mild allergic reactions if exposed over long periods.
Hazard Pictograms: None usually assigned, but care makes sense due to dust risk.
Signal Word: None required for non-industrial exposures, but using common sense helps everyone around.
Ingredient: N-Hippuryl-L-histidyl-L-leucine hydrate
Chemical Formula: C22H29N5O6
CAS Number: 68416-42-8
Impurities: None relevant in reagent-grade material; trace water from hydration only
Eye Contact: Rinse immediately with plenty of water. Remove contact lenses. Seek medical attention if irritation continues.
Skin Contact: Wash with soap and water; change contaminated clothing.
Inhalation: Move to fresh air, breathe normally and consult a physician if discomfort remains.
Ingestion: Rinse mouth with water. Medical attention recommended if large amount swallowed or symptoms occur.
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical.
Specific Hazards: Fine, combustible dust could contribute to fire intensity in concentrated form.
Protective Equipment: Firefighters should put on self-contained breathing apparatus and standard protective gear in an emergency.
Decomposition Gases: Burning may release nitrogen oxides and carbon oxides.
Personal Precautions: Use gloves and dust mask. Avoid breathing dust or letting it contact skin or eyes.
Clean-Up Method: Sweep up without creating dust cloud. Dispose in a properly labeled container for chemical waste. Wipe surface afterwards with water.
Environmental Precautions: Prevent entry into drains or natural waterways—powder residue can become an environmental nuisance.
Handling: Avoid raising dust; use inside fume hood if possible. Wear gloves and lab coat, and keep containers tightly closed.
Storage: Store in a cool, dry location away from strong acids, bases, or oxidizers. Protect from light and moisture to keep potency. Keep material segregated from common food areas.
Engineering Controls: Use laboratory ventilation; work in fume hood for large quantities or procedures that make airborne powder.
Personal Protective Equipment: Standard nitrile gloves, chemical-resistant eye protection, and lab coats or gowns.
Respiratory Protection: Dust mask for large volumes or procedures that could generate fine airborne particles.
Hygiene Measures: Wash hands after use and before eating or drinking. Remove contaminated clothing and wash before reuse.
Appearance: Powder, white to off-white color
Odor: No distinctive odor
Solubility: Soluble in water
Melting Point: Data not widely reported; generally stable at ambient lab temperatures
pH (solution): Neutral to slightly acidic, depending on concentration in water
Boiling Point: Decomposes before boiling
Reactivity: No unusually reactive groups; stable under normal use
Chemical Stability: Stable at room temperature; excessive heat, moisture or UV light can degrade compound
Incompatible Materials: Strong acids, bases, or oxidizing agents; those could break the molecule down or create heat
Hazardous Decomposition: May form carbon oxides and nitrogen oxides on burning
Acute Toxicity: No known serious toxicity for typical lab use
Potential Effects: Possible irritation of eyes, skin, and airway with direct contact
Long-Term Exposure: No extensive studies, but repeated exposure to dust raises risk of allergy or sensitivity
Carcinogenicity: Not listed as carcinogen by major health agencies
Routes of Exposure: Eye and skin contact, inhalation, unintentional ingestion
Environmental Fate: Limited data, but as a peptide, it likely breaks down over time in soil and water
Aquatic Toxicity: No reports of high toxicity to aquatic organisms
Persistence: Biodegradable; does not build up in organisms
Bioaccumulation: Unlikely given structure and water solubility
Waste Disposal: Collect powder or solution in a sealable chemical waste container. Use a qualified hazardous waste contractor who follows local, state, and federal guidelines
Disposal of Containers: Rinse empty containers before discarding with laboratory trash, unless contaminated with hazardous material
Avoid: Pouring contents down laboratory drains or into regular trash
UN Number: Not regulated as a dangerous good
Shipping Precautions: Inside sealed, clearly labeled packaging to prevent leaks and dust formation during transit
Regulatory Restrictions: No special requirements for ground or air transport for research samples
US Regulations: This peptide is not on major hazardous substance lists including SARA Title III or TSCA
International Status: No special limits in EU REACH or other chemical inventories
Lab Compliance: Labs handling this compound should maintain good records, proper labeling, and general chemical safety protocols in line with university or institutional rules
