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Product Name: N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide Hydrochloride
Synonyms: EDC HCl, 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride
Chemical Formula: C8H17N3·HCl
CAS Number: 25952-53-8
Recommended Use: Reagent for peptide coupling, pharmaceutical research, laboratory chemical
Company Identification: Manufacturer name, address, and phone number should be stated on the supplied MSDS
Emergency Contact: Emergency phone number for hazardous chemical response
Classification: Eye damage/irritation (Category 1), Skin irritation (Category 2), Acute toxicity oral (Category 4)
GHS Label Elements: Danger symbol with exclamation mark and corrosion pictogram
Hazard Statements: Causes serious eye damage, causes skin irritation, harmful if swallowed
Precautionary Statements: Use protective gear, avoid inhalation, wash hands after handling, store locked up
Potential Health Effects: Eye, skin, and respiratory tract irritation, gastrointestinal distress on ingestion
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Environmental Hazards: Harmful to aquatic life, potential for waterway contamination
Chemical Name: N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide Hydrochloride
Common Name: EDC・HCl
Concentration: 98-100% (pure substance, laboratory grade)
CAS Number: 25952-53-8
Impurities/Additives: Typically not significant but may include trace moisture or stabilizers depending on supplier
General Advice: Remove victim from exposure area, seek medical attention for pronounced symptoms or persistent irritation
Inhalation: Move to fresh air, keep at rest, monitor for respiratory distress, administer oxygen if breathing becomes difficult, get medical attention if symptoms occur
Skin Contact: Remove contaminated clothing, wash with copious water and soap for at least 15 minutes, do not use solvents for cleaning skin, seek medical advice if irritation persists
Eye Contact: Rinse immediately with plenty of water, lifting eyelids occasionally, continue for at least 15 minutes, remove contact lenses if present, urgent medical attention needed
Ingestion: Do not induce vomiting, rinse mouth with water, offer water to drink if conscious, seek immediate medical attention
Symptoms and Effects: Redness, blistering, irritation, coughing, nausea, vomiting, stomach pain, lacrimation, blurred vision
Note to Physician: Treat symptomatically and monitor airway and respiratory function; provide supportive treatment as needed
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide
Specific Fire Hazards: Product decomposes at high temperatures releasing toxic gases including nitrogen oxides, carbon oxides, hydrogen chloride
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and fully protective suit
Unusual Fire/Explosion Hazards: Fine dust can form explosive mixtures with air, minimize dust generation
Advice for Firefighters: Avoid inhalation of combustion products, contain and collect contaminated extinguishing water separately to avoid environmental release
Personal Precautions: Evacuate area, wear suitable respiratory protection and chemical-resistant gloves, avoid skin and eye contact, prohibit sources of ignition
Environmental Precautions: Prevent spillage from reaching drains, watercourses, or soil, report environmental release to local authorities as required
Cleanup Methods: Sweep up powder without creating dust, collect in closed containers for proper disposal, clean spill area with water and detergent, ventilate area after cleanup
Emergency Procedures: Notify safety personnel, restrict access until cleanup is complete, use spark-proof tools and equipment
Handling: Use in chemical fume hood, minimize aerosol or dust generation, avoid contact with skin, eyes, and clothing; keep containers tightly closed; wear appropriate protective equipment
Technical Controls: Local exhaust ventilation, use explosion-proof equipment, maintain good industrial hygiene practices
Storage: Store in cool, dry, well-ventilated area away from moisture and incompatible substances like strong acids, bases, or oxidizers; keep container tightly sealed, label area with hazard symbols and emergency contact information
Incompatible Materials: Strong bases, strong acids, oxidizing agents, moisture, heat sources
Occupational Exposure Limits: No established US OSHA PEL or ACGIH TLV; supplier-recommended exposure guidelines should be followed minimum level
Engineering Controls: Chemical fume hood or local exhaust, eyewash stations and safety showers in work areas
Personal Protective Equipment (PPE): NIOSH/MSHA-approved respirator if airborne exposure risk is significant; chemical safety goggles; lab coat or chemical-resistant clothing; chemical-resistant gloves (nitrile or neoprene recommended); avoid wearing contact lenses
Work Hygienic Practices: Remove contaminated clothes, wash hands thoroughly after handling, do not eat, drink, or smoke during use
Appearance: White to off-white crystalline powder
Odor: Characteristic, weak amine-like
Odor Threshold: Not determined
pH: (1% solution) approx. 4.0-6.0
Melting Point/Range: 110-115°C (decomposes)
Boiling Point/Range: Decomposes before boiling
Flash Point: Not applicable
Evaporation Rate: Not determined
Flammability (Solid, Gas): Product not classified as flammable under standard conditions
Vapor Pressure: Not determined
Vapor Density: Not determined
Relative Density: Approx. 0.68-0.75 g/cm³
Solubility: Soluble in water, soluble in polar organic solvents
Partition Coefficient: Not determined
Autoignition Temperature: Not determined
Decomposition Temperature: Above 110°C
Viscosity: Not applicable (solid)
Chemical Stability: Stable under recommended storage conditions, reacts with moisture and heat
Hazardous Reactions: Can react exothermically with acids, bases, and oxidizers with possible gas evolution and heat production
Conditions to Avoid: Exposure to moisture, high temperatures, direct sunlight
Incompatible Materials: Acids, alkalis, oxidizing agents, strong reducing agents
Hazardous Decomposition Products: Carbon oxides (CO, CO2), nitrogen oxides, hydrogen chloride gases, possible amines
Acute Toxicity (Oral): LD50 (rat) reported values range 200-2000 mg/kg
Acute Toxicity (Dermal): Data limited, may cause irritation with prolonged exposure
Acute Toxicity (Inhalation): No classified data for inhalation, nuisance dust or aerosol can irritate respiratory tract
Skin Corrosion/Irritation: Causes irritation, redness, and possible blistering on contact
Serious Eye Damage/Irritation: Risk of severe eye damage with direct contact
Respiratory or Skin Sensitization: Not conclusively tested, reports of allergic reactions rare
Germ Cell Mutagenicity: Not classified
Carcinogenicity: Not listed in NTP, IARC or OSHA as a carcinogen
Reproductive Toxicity: Not classified based on available data
Specific Target Organ Toxicity (Single/Repeated Exposure): No conclusive findings for specific organ toxicity
Medical Conditions Aggravated by Exposure: Pre-existing skin, eye, respiratory disorders
Ecotoxicity: Product harmful to aquatic organisms based on structure and toxicity profile
Persistence and Degradability: Biodegradability potential not fully documented
Bioaccumulative Potential: Not expected to significantly bioaccumulate based on chemical structure and solubility
Mobility in Soil: Water solubility suggests mobility, risk of leaching into groundwater exists
Other Adverse Effects: Avoid direct discharge to surface water; available data limited on long-term environmental impacts
Waste Treatment Methods: Dispose of in accordance with local, state, and federal regulations; do not pour down drain or mix with municipal garbage
Contaminated Packaging: Decontaminate if possible and recycle or dispose as hazardous waste
Environmental Precautions: Prevent run-off to sewers/waterways during disposal; consult waste disposal contractor for chemical incineration
Recommended Disposal: Collect as hazardous chemical waste, recommend incineration at permitted facility
UN Number: Not regulated as hazardous for transport under UN criteria
Proper Shipping Name: Not classified as dangerous goods under ADR/RID/IMDG/IATA
Transport Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not classified as marine pollutant
Transport Precautions: Transport in tightly sealed, clearly labeled containers, avoid contact with moisture, shield from physical damage
Global Inventories: Registered under several major inventories including US TSCA, EU REACH, Canada DSL, Australia AICS, Japan ENCS
OSHA Hazards: Hazardous chemical as defined by OSHA Hazard Communication Standard (29 CFR 1910.1200)
SARA Title III: Not listed as an Extremely Hazardous Substance, no specific Section 313 requirements
California Proposition 65: This product does not contain chemicals known to the State of California to cause cancer, birth defects, or reproductive harm
WHMIS Classification: D2B (Toxic Material Causing Other Toxic Effects) in Canada
EU Classification: Eye damage (Category 1), Skin irritation (Category 2), Harmful if swallowed (Category 4)
Labeling Required: Ensure products sold or distributed in compliance with local regulation, provide hazard pictogram and supplier label
