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Product Name: Nω-Nitro-L-arginine Methyl Ester Hydrochloride
Chemical Formula: C7H15N5O4 · HCl
Synonyms: L-NAME, Nomega-Nitro-L-arginine methyl ester hydrochloride, L-Nitroarginine methyl ester
Intended Use: Research reagent, laboratory chemical
Appearance: White to off-white powder
CAS Number: 51298-62-5
Classification: May cause irritation to skin, eyes, and respiratory tract; lacks detailed chronic exposure studies
GHS Pictograms: Exclamation mark for irritant
Routes of Exposure: Skin contact, inhalation, ingestion, eye contact
Potential Effects: Short-term exposure may result in symptoms like coughing, shortness of breath, skin redness, or eye watering
Precautionary Statements: Prevent dust generation, avoid breathing dust, wash thoroughly after handling, use in well-ventilated spaces
Hazards: Not listed as carcinogenic, mutagenic, or toxic for reproduction by IARC, NTP, or OSHA
Chemical: Nω-Nitro-L-arginine Methyl Ester Hydrochloride
Purity: Typically greater than 98% in research settings
Impurities: Rarely present at significant levels in reputable sources
Formulation: No additional stabilizers or buffer agents commonly included
Skin Contact: Wash skin thoroughly with soap and water, remove contaminated clothing
Eye Contact: Rinse eyes cautiously with water for several minutes, remove contact lenses if present and easy to do
Inhalation: Move to fresh air, seek medical attention if symptoms persist
Ingestion: Rinse mouth with water, call a physician if feeling unwell
General Advice: Immediate medical attention not always necessary for minor exposure but attention to symptoms important for laboratory workers
Suitable Extinguishing Media: Use water spray, carbon dioxide, dry chemical powder, or foam
Specific Hazards: Material may decompose under fire conditions, producing toxic nitrogen oxides and carbon oxides
Protective Equipment: Firefighters should wear self-contained breathing apparatus and protective clothing
Flammability: Product is not highly flammable but can support combustion if involved in a fire
Personal Precautions: Use appropriate personal protective equipment, avoid dust formation, ventilate area
Environmental Protection: Keep material out of drains, surface waters, and soil
Spill Cleanup: Sweep up and collect spilled material using non-sparking tools, dispose as chemical waste, wash spill site thoroughly after material pickup
Handling: Handle in compliance with good industrial hygiene and safety practices, avoid contact with skin and eyes, avoid inhalation of dust and vapors
Storage: Store in tightly closed containers at 2-8°C, keep material in a dry, cool, and well-ventilated space, segregate from incompatible materials
Precautions: Always use appropriate personal protection, do not eat, drink, or smoke while handling, prevent dust accumulation
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to keep airborne levels below recommended exposure limits
Respiratory Protection: Use NIOSH/MSHA approved respirators suited to conditions
Skin Protection: Wear protective gloves, lab coat, and long-sleeved clothing
Eye Protection: Use chemical safety goggles or face shield
Workplace Hygiene: Wash hands thoroughly after handling, do not bring contaminated items out of the laboratory environment
Physical State: Solid powder
Color: White to off-white
Odor: Odorless
Melting Point: Not widely documented
Solubility: Soluble in water
pH (solution): Slightly acidic in aqueous solutions
Stability: Stable under recommended storage conditions
Molecular Weight: Approximately 267.7 g/mol (hydrochloride salt)
Chemical Stability: Stable under regular laboratory storage conditions
Conditions to Avoid: Exposure to heat, moisture, and incompatible materials like strong oxidizing agents
Hazardous Decomposition: May produce toxic gases such as nitrogen oxides and carbon oxides
Polymerization: Not known to occur
Acute Toxicity: Information specific to compound is limited; structurally similar compounds suggest low acute toxicity in small, research-level exposures
Skin/Eye Irritation: May cause irritation
Inhalation Effects: May cause respiratory tract irritation, coughing or discomfort
Sensitization: No comprehensive data available
Chronic Effects: No long-term effects documented in scientific literature for normal laboratory handling
Health Risks: Handling with care eliminates most risks, yet unexpected reactions can still occur for sensitive individuals
Ecotoxicity: No specific studies found; responsible disposal and non-release to environment remain best practice
Persistence and Degradability: No detailed environmental fate data from large-scale studies
Bioaccumulative Potential: Low likelihood due to laboratory scale and handling as non-volatile, water-soluble material
Mobility in Soil: Water-soluble, likely to distribute in aqueous phase if released
Disposal Methods: Dispose of contents and container according to federal, state, and local regulations
Precautions: Contaminated packaging must be treated as chemical waste, avoid disposal into drains or natural water sources
Shipping Classification: Laboratory-scale shipments rarely meet hazardous materials threshold
UN Number: Not assigned for this compound in plain solid form
Packaging: Use leak-proof containers, cushioned and labeled in accordance with regulations
Transport Precautions: Store upright, prevent container damage, shield from heat and moisture during transit
Chemical Regulations: Not listed by US EPA or other North American chemical hazard registries as a hazardous or regulated chemical for research usage
Occupational Limits: No established OSHA or ACGIH exposure limits
Labeling: GHS classification for irritation, laboratory use only, not for diagnostic or therapeutic purposes
Environmental Regulations: Common laboratory best practice calls for measures to prevent chemical pollution, even for compounds lacking specific regulatory listing
