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Product Name: Modified Griess Reagent
Common Names: Diazotization Reagent, Nitrite Detection Solution
Recommended Use: Laboratory analysis of nitrite content
Manufacturer: Academic and clinical chemical suppliers
Contact Information: Emergency phone numbers available from local laboratory safety office
Product Codes: Provided by supplier
Relevant Identified Uses: Analytical chemistry, forensic toxicology, water testing
Health Hazards: Causes skin and eye irritation, harmful if swallowed or inhaled, possible allergic skin reaction
Physical Hazards: Combustible components, mild oxidizer effect
Environmental Hazards: Toxic to aquatic life with long lasting effects
Signal Word: Warning
Hazard Statements: H302 Harmful if swallowed, H315 Causes skin irritation, H319 Causes serious eye irritation, H412 Harmful to aquatic life
Pictograms: Exclamation mark, Environmental hazard
Component 1: Sulfanilamide 1-5%, CAS 63-74-1
Component 2: N-(1-naphthyl)ethylenediamine dihydrochloride 0.1-1%, CAS 1465-25-4
Component 3: Phosphoric acid (85%) 10-30%, CAS 7664-38-2
Additional Components: Distilled water to 100%
Impurities / Stabilizers: Not significant in standard formulations
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes, hold eyelids open, seek medical attention
Skin Contact: Wash with soap and water, remove contaminated clothing, seek medical advice if irritation persists
Inhalation: Move person to fresh air, keep comfortable, provide oxygen if breathing difficulties develop, obtain medical attention
Ingestion: Rinse mouth, do not induce vomiting, call poison control or physician immediately
Special Notes for Physicians: Treat symptomatically, support vital functions
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: Strong water jets in confined spaces
Specific Hazards: May emit toxic fumes of nitrogen oxides, sulfur oxides, and phosphorus oxides during combustion
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective clothing
Advice for Firefighters: Use caution, cool containers exposed to heat with water spray, contain runoff to prevent environmental contamination
Personal Precautions: Wear gloves, protective goggles, laboratory coat, and mask to avoid inhalation and contact with skin
Environmental Precautions: Prevent entry into sewers or natural waters, inform authorities in case of major spillage
Methods for Clean-up: Absorb spill with inert material such as sand or vermiculite, collect in labeled containers for disposal, ventilate area, wash spill site thoroughly
Handling: Avoid inhalation, ingestion, or contact with eyes and skin, work in well-ventilated area, use fume hood for procedures producing vapor or aerosols
Storage: Store at room temperature in tightly sealed container, away from strong bases, oxidizers, or reducing agents, keep in original container clearly labeled, protect from moisture and direct sunlight, restrict access to trained personnel
Engineering Controls: Use laboratory fume hood, maintain appropriate ventilation, emergency eyewash and safety shower accessible
Personal Protective Equipment: Lab goggles, chemical-resistant gloves (nitrile), lab coat, closed-toe footwear
Respiratory Protection: Respirator or mask if risk of inhalation exists or exposure limits may be exceeded
Occupational Exposure Limits: Phosphoric acid: OSHA PEL 1 mg/m3 TWA
Hygiene Measures: Wash hands thoroughly after handling, avoid eating or drinking in work area, remove contaminated clothing and wash before reuse
Appearance: Clear, pink to red liquid
Odor: Mild acidic odor
Odor Threshold: Not established
pH: Acidic, typically around 1-2
Melting Point/Freezing Point: Similar to water
Boiling Point: Approximately 100°C (solution basis)
Flash Point: Not flammable
Evaporation Rate: Comparable to water
Flammability: Not readily flammable
Vapor Pressure: Not significant at room temperature
Vapor Density: Not determined
Solubility: Completely soluble in water
Partition Coefficient (n-octanol/water): Not determined
Auto-ignition Temperature: Not applicable
Decomposition Temperature: Above 150°C
Viscosity: Similar to water
Reactivity: Stable under recommended storage and handling conditions
Chemical Stability: Shelf-stable at room temperature, sensitive to light and heat
Possibility of Hazardous Reactions: Reacts strongly with strong bases, oxidizers, and certain metals
Conditions to Avoid: Excessive heat, direct sunlight, froze storage
Incompatible Materials: Strong alkalies, reducing agents, oxidizing materials, metals such as sodium, potassium
Hazardous Decomposition Products: Nitrogen oxides, phosphorus oxides, sulfur oxides, carbon monoxide and carbon dioxide under fire
Likely Routes of Exposure: Inhalation, ingestion, skin, and eye contact
Symptoms: Irritation of eyes, skin, respiratory tract; redness, pain, nausea, headache possible on overexposure
Acute Toxicity: May cause gastrointestinal distress or respiratory irritation
Skin Corrosion/Irritation: Causes irritation, prolonged or repeated contact increases risk
Serious Eye Damage/Irritation: Severe irritation and redness, possible corneal injury
Respiratory or Skin Sensitization: Sensitization possible, rare cases of allergic reaction documented
Chronic Effects: Prolonged exposure increases risk of dermatitis, respiratory issues
Carcinogenicity: Not listed as carcinogenic by IARC, NTP, OSHA
Other Data: Low-level evidence of reproductive toxicity in animal studies with components; limited data in humans
Ecotoxicity: Toxic to aquatic life due to phosphoric acid and aromatic amine components
Persistence and Degradability: Components degrade slowly in environment
Bioaccumulation: Possible for aromatic amines, low for phosphoric acid
Mobility in Soil: Mobile in water, potential groundwater contaminant
Other Adverse Effects: Changes in water pH, disruption to aquatic organisms at low concentrations, proper waste treatment required to prevent long-term impacts
Waste Treatment Methods: Dispose of as hazardous laboratory chemical waste under local, state, and federal regulations
Contaminated Packaging: Rinse thoroughly, treat rinse with hazardous waste, discard per local guidelines
Special Precautions: Prevent discharge to drains or environment, do not mix with incompatible waste streams, consult waste disposal professionals
Preferred Methods: Chemical neutralization with sodium bicarbonate for small quantities, secure transport to licensed disposal facility
UN Number: 1805 (applies to phosphoric acid solutions; usual shipping name for small chemical quantities)
UN Proper Shipping Name: Phosphoric acid solution
Transport Hazard Class(es): 8 (Corrosive substances)
Packing Group: III
Environmental Hazards: Marine pollutant (consult specific shipping regulations)
Transport Labels: Corrosive
Special Precautions for Transport: Secure containers, avoid leaks, complete shipping documentation, inform carrier of any spills or leaks
OSHA Status: Hazardous chemical, subject to Safety Data Sheet requirements
TSCA Status: All ingredients listed or exempted
SARA Title III: Some components appear in SARA inventory; follows reporting requirements
California Proposition 65: Compounds related to aromatic amines may be listed
WHMIS Classification (Canada): Class D2B (Toxic), Class E (Corrosive Material)
Other International Regulations: Complies with GHS labeling, EU CLP, and REACH registration for supplied quantities
Worker Protection: Training mandatory for handling, medical surveillance for routine users recommended, regular review of SDS for compliance and safety updates
