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Product Name: MISSION PRED siRNA
Synonyms: Short-interfering RNA for gene silencing
Recommended Use: Research applications in gene function studies
Supplier: MilliporeSigma Life Science
Emergency Contact: CHEMTREC, +1-800-424-9300
CAS Number: Proprietary blend (not assigned to modified RNA)
Email Contact: TechnicalService@milliporesigma.com
Product Code: Specific to lot and batch; found on product vial
Classification: Non-hazardous under OSHA’s Hazard Communication Standard
Label Elements: No hazard pictogram required
Signal Word: None
Hazard Statements: No specific hazards identified under normal laboratory handling; avoid inhalation, ingestion, or skin contact
Precautionary Statements: Use care to prevent dust formation; limit exposure by following standard laboratory hygiene guidelines
Physical Hazards: Non-flammable, non-explosive, non-reactive under routine use
Health Hazards: Mild irritation possible on direct contact with eyes, skin, or by inhalation in high concentrations
Chemical Nature: Synthetic double-stranded RNA oligonucleotide
Main Component: Chemically modified siRNA duplex
Purity: ≥98% (HPLC purified)
Additives: Trace amounts of sodium chloride, sodium phosphate buffer, and water
Impurities: None expected above threshold for classification; minor synthesis by-products
Concentration Range: Typically lyophilized, 10-100 nanomole quantity per vial
Eye Contact: Immediately flush eyes with copious amounts of water; seek medical attention if irritation persists
Skin Contact: Wash with soap and water; remove contaminated clothing; consult a physician if symptoms continue
Inhalation: Move to fresh air; provide oxygen or artificial respiration if needed; contact a doctor
Ingestion: Rinse mouth with water; seek medical advice, presenting product information
Acute Effects: Mild irritation if in direct contact; no known systemic toxicity from limited accidental exposure
Recommended Protection: Laboratory gloves, eye protection, lab coat
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical powder, foam
Unsuitable Media: None known based on product composition
Fire Hazards: Product does not ignite easily; dust may cause minor fire risk if exposed to ignition source in large amounts
Explosion Hazards: Not expected under normal handling
Special Protective Equipment: Firefighters should wear standard self-contained breathing apparatus and full turnout gear
Combustion Products: Oxides of carbon, nitrogen, and minor organic fragments
Specific Methods: Use water spray to cool fire-exposed surfaces; avoid runoff entering drains
Personal Precautions: Avoid direct contact with material; ventilate area; wear gloves, mask, and protective clothing
Environmental Precautions: Prevent release into surface waters, soil, or public sewers; collect spills swiftly to minimize discharge
Cleanup Methods: Gather spilled powder using moist absorbent material; wipe surfaces thoroughly with mild detergent; place in a biological waste container
Disposal: Consult disposal considerations below; incinerate or process as regulated biological waste
Safe Handling: Work in a clean, ventilated lab; avoid generating dust; keep container closed; use proper hygiene after handling
Technical Measures: Use biosafety cabinet if risk of aerosolization
Storage Requirements: Store at -20°C or lower for long-term stability; keep dry; avoid repeated freeze-thaw cycles
Incompatible Materials: Strong acids, oxidizers, and bases
Recommended Containers: Original tightly sealed vials with appropriate labeling
Exposure Limits: No occupational exposure limits established for siRNA
Engineering Controls: Use local exhaust ventilation; biological safety cabinet as needed
Hygiene Measures: Wash hands thoroughly; avoid eating or drinking while working with product
Personal Protective Equipment: Laboratory gloves (nitrile or latex), safety glasses/goggles, lab coat; respirators not generally required for standard handling
Appearance: White to off-white lyophilized powder or solid pellet
Odor: Odorless
Solubility: Soluble in water or buffer solutions
pH: Approximately neutral in reconstitution buffer (pH 7.0–7.4)
Melting Point: Not applicable
Boiling Point: Not applicable
Vapor Pressure: Not volatile
Flash Point: Not flammable
Other Critical Properties: Stable when stored cold and protected from light
Chemical Stability: Product remains stable under specified storage conditions; hydrolysis risk at higher temperatures or with moisture
Incompatible Reactants: Avoid strong acids, alkali, oxidizers
Conditions to Avoid: Direct sunlight, excessive heat, repeated freeze/thaw
Hazardous Decomposition: Minor organics (COx, NOx) possible if combusted
Acute Toxicity: No toxic effects observed in typical laboratory conditions
Chronic Toxicity: Repeated exposure data not available; no cumulative toxicity reported in literature
POTENTIAL ROUTES OF ENTRY: Skin, eye, inhalation, ingestion
Irritation: May cause mild eye, skin, or respiratory irritation
Target Organs: No specific organ toxicity anticipated from laboratory exposure
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Mutagenicity/Reproductive Effects: No mutagenic or reproductive risks identified in in vitro or animal studies
Ecotoxicity: Low environmental hazard under controlled laboratory use; high dilution on accidental release
Persistence/Degradability: Rapidly degraded by nucleases in the environment
Bioaccumulation: Not expected to bioaccumulate or persist
Mobility: Readily disperses in aqueous media; not volatile
Other Adverse Effects: Minimal risk to aquatic or soil organisms due to biological origin and rapid breakdown
Precaution in Disposal: Prevent large volumes from entering waterways or drains
Waste Generation: Collect all unused material, contaminated items, and cleanup debris as biological waste
Disposal Methods: Incinerate following institutional biosafety guidelines; consult local regulations; avoid landfill where prohibited
Container Disposal: Triple rinse then dispose as laboratory waste or biohazard, depending on local authority requirements
Regulatory Compliance: Follow all federal, state, and local regulations on genetically modified biological substances
UN Number: Not regulated for transport
Proper Shipping Name: Not dangerous; “Not restricted” (IATA/IMDG/ADR/RID)
Packaging Requirements: Use secondary leak-proof packaging; insulated shipping recommended for cold chain
Transport Hazards: No special hazards
Special Precautions: Include appropriate documentation; keep cool and dry during transit
US Regulations: Non-hazardous per OSHA 29 CFR 1910.1200; TSCA exemption for research use
EU Regulations: Not classified as hazardous under CLP Regulation (EC) No 1272/2008
Japanese Law: Not subject to PRTR or CSCL for laboratory research
Canada: Not controlled under WHMIS; for research use by qualified individuals
Other Regulations: Observe appropriate workplace genetic material handling policies; may be subject to institutional biosafety review depending on application
Product Use Restriction: Not for human or animal therapeutic use; for research only
