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Methylamine (40 WT.% Solution in Water): A Practical Look

Historical Development

People began working with methylamine during the early days of organic chemistry. The chemical world always had a soft spot for simple amines, and methylamine fit the bill perfectly. Early formula books from the nineteenth century mention it as a key intermediate. Chemists started out making it in the lab by distilling a mix of formaldehyde and ammonium chloride, a method anyone with some glassware could pull off. Over the decades, the scale grew. Industrial synthesis caught up, and by the middle of the twentieth century, methylamine started showing up in tankers, feeding all sorts of downstream chemistry. Agricultural, pharmaceutical, and polymer industries all found uses for it. The 40% solution format took off because it gave factories a safer way to handle methylamine with physical controls built in—less risk than anhydrous gas, easier to measure out, and not as likely to outgas dangerously. Before modern shipping standards, the fear of leaks or pressure buildup limited large scale use. Innovations in both production and container design widened its market. That history shaped how the product looks today: a common chemical, handled every day.

Product Overview

Methylamine in a 40% aqueous solution blends practicality with versatility. The solution contains about 40% methylamine by weight in water, making it much more manageable than pure methylamine, a gas at room temperature. The dissolved gas forms a colorless to slightly yellowish liquid that gives off a strong, fishy odor reminiscent of ammonia. Anyone who's worked with ammonia in a lab recognizes the smell instantly. Provided in bulk drums, intermediate totes, or, for smaller operations, bottles, the solution arrives with all the paperwork needed: batch numbers, hazard symbols, and safety data. The mix isn’t just about convenience—it prevents losses to evaporation and provides a way to meter methylamine accurately into batch reactors or pipelines. Industries appreciate this straight-forward format because it takes a lot of the guesswork out of handling what can be a tricky chemical.

Physical & Chemical Properties

On first glance, methylamine solution might not stick out. The colorless liquid doesn't attract attention, but there's plenty going on in that bottle. Its boiling point sits well over that of pure methylamine, due to the presence of water. The solution blends the volatility of methylamine with the moderating power of water, which keeps things a bit safer. Anyone who's knocked over a bottle learns that the vapors sting the nose and eyes; the amine smell clears out a room quickly. It mixes well with alcohols, ketones, and other polar solvents. Acids neutralize it in a flash, forming methylammonium salts. Its basicity makes it reactive and easy to spot with pH paper or indicators. The water content sets this product apart from compressed methylamine gas or the anhydrous stuff, making containment much less of a headache, especially in climate varying between cold and hot.

Technical Specifications & Labeling

Spec sheets run long for methylamine. Buyers need to know what they're getting. Purity often exceeds 98% on a methylamine basis, with the rest being water for the total 100%. Minor impurities, usually ranging from dimethylamine and ammonia to trace organic residues, show up on the certificate of analysis but rarely affect most uses. Totes or drums have UN-approved hazardous chemical labels, a flammable warning, and a corrosive warning. Companies check for tightness in seals and closures, as the vapor pressure can build up in storage. The Safety Data Sheet highlights proper PPE, ventilation, and first aid; it's required reading for anyone receiving a shipment. Temperature is important for storage, with recommendations keeping the solution above freezing but well below 40°C to avoid offgassing. Most suppliers include an expiry date, typically one to two years out, to guarantee the spec meets safety and performance needs.

Preparation Method

Making methylamine solution at scale usually starts with reacting methanol with ammonia over a catalyst at elevated temperature and pressure. After cooling, separation, and purification, the gas is pumped straight into cold, deionized water, saturating the liquid until the 40% weight is reached. Smaller operations can bubble pure methylamine into measured water under controlled conditions, but that's rare outside of specialty labs since it takes careful monitoring to prevent overexposure and vapor buildup. Some labs rely on the classic in situ generation using formaldehyde, ammonia, and an acid or base catalyst, but this results in extra byproducts and often can't match the neatly labeled, industrially produced stuff. Producers watch not just the concentration but also the pH, clarity, and absence of particulate before shipping. Inefficient transfer or mixing can easily lead to pressure spikes or product out of spec, so skilled operators stay close to the process.

Chemical Reactions & Modifications

Methylamine acts like its amine cousins, tackling a wide array of classic organic reactions. Its most common action is nucleophilic substitution, breaking into carbon chains by swapping places with halogen or leaving groups. It's a workhorse for making pharmaceuticals: a key step in many antihistamines and analgesics. Methylamine meshes well with sulfonyl chlorides, acyl chlorides, and carboxylic acids, shaping everything from dyes to fungicides. Reductive aminations make use of its reactive nitrogen, while methylamine salts serve as precursors for longer chain amines and quaternary ammonium compounds. In polymer chemistry, methylamine introduces amine groups to linkers and monomers, helping to create adhesives or modifying starches. Sometimes, chemists tweak its structure further, swapping in isotopic labels or using it as a building block for custom molecules. Those interested in green chemistry focus on finding routes that cut down on related byproduct formation or energy use as new catalytic methods emerge.

Synonyms & Product Names

Methylamine goes by a few other names, each marking a spot in chemical nomenclature. Mono-methylamine shows up on older safety sheets, hinting at its structure compared to its di- and tri-methyl cousins. Some labels stick with the simple “methylamine, aqueous solution” or “40% methylamine in water.” Formulas appear as CH3NH2, or less often as methylazanide in more technical texts. Shipping names under the UN coding refer to this as UN1235, linking it to international transport protocols aimed at keeping it away from incompatible goods. Vendor catalogues sometimes list it as “methylamine, stabilized,” referring to additives that help give extra shelf life or reduce corrosion in stainless steel containers. Regardless of the name chosen, the paperwork trails help avoid mix-ups in receiving or regulatory reporting, which is crucial given the substance’s many uses and the regulations controlling who can order and store it.

Safety & Operational Standards

Handling methylamine solution means thinking about both chemical exposure and vapor risks. The solution’s strong base and potent vapor demand gloves, goggles, and often full-face respirators in poorly ventilated spaces. Labs and plants keep emergency showers and eyewash stations ready in case of splash. Anyone unloading bulk methylamine wears PPE according to strict company protocols—face shields, impervious gloves, chemical aprons, the works. Leaks or spills reach the nose long before the eyes, but vapors can sneak up if ventilation isn’t strong enough. Storage runs best in dedicated chemical rooms with limits on temperature and direct sunlight. Because methylamine enjoys reacting with acids and oxidizers, these materials get kept separately by facility teams. Routine safety drills cover everything from small spills to large leaks or releases, giving everyone practice in sealing off and ventilating the area. Fire is less of a risk in solution than in gas form, but the flammability remains a concern if large amounts evaporate. Local, national, and international regulations all weigh in: from OSHA to REACH to the UN, authorities each add a layer of compliance. The key with methylamine is simple—never underestimate a solution just because it’s diluted.

Application Area

Demand for methylamine stretches far and wide. Players in the pharmaceutical space need it for making everything from over-the-counter allergy drugs to chemotherapy agents. Agricultural suppliers pull it into herbicide, fungicide, and pesticide formulas, taking advantage of its role in building biologically active molecules. Water treatment plants have long found a use for methylamine salts as flocculants and as corrosion inhibitors, keeping equipment running longer. It also plays a role in textile and dye industries, coloring synthetics and helping fix pigments to fibers. In adhesives manufacturing, some lines depend on methylamine for producing cross-linking agents. New batteries and electronics projects look to methylamine derivatives for advanced conductive polymers. Academia remains a steady buyer as well—organic synthetists everywhere still teach students reactions on a methylamine backbone. Every one of these uses relies on methylamine’s ready reactivity and the balanced safety profile of the 40% solution, which many find just right for reliable dosing and handling.

Research & Development

Researchers have always looked for new ways to make and use methylamine. Recent years see efforts aimed at greener catalytic methods, moving away from high-temperature, high-pressure processes toward milder, more selective reactions. Teams study enzyme-driven routes, hoping to reduce waste and energy use, especially as sustainability goals grow more important in chemical manufacturing. Pharmaceutical chemists constantly pursue new synthetic methods, using methylamine to stitch together more complex molecules for therapies not yet on the market. Painstaking process development work has improved yields and cut costs for existing pathways. Universities dig into reaction kinetics, charting out every side-product and figuring out how to bias reactions toward the desired product. Safety-focused research looks at evaporation rates, storage stability, and strategies for remote monitoring—anything to help facilities run with fewer surprises. The resulting patents and publications keep methylamine-related chemistry a live topic in conferences and journals, supporting an ecosystem of incremental innovation.

Toxicity Research

Concerns around methylamine’s health effects shaped how workplaces approach its use. Acute exposure causes immediate irritation to eyes, skin, and the respiratory tract, driving home the importance of closed systems and ventilation. Long-term studies show that while it doesn’t build up in the body, repeated high-level exposure can aggravate pre-existing respiratory issues. Animal models hint at central nervous system effects at very high doses, but real-life worker exposure rarely reaches these extremes with proper controls. Emergency treatment focuses on moving victims to fresh air, flushing eyes and skin with water, and, in rare cases, providing supplemental oxygen. Regulatory agencies set airborne exposure limits—such as OSHA’s permissible exposure limit at 10 ppm—to help guide safe operation. Continued research focuses on chronic effects, developing better biomarkers for exposure, and ways to minimize offgassing or accidental splashes during transport and transfer. Toxicology work gets shared widely, helping both regulators and companies keep best practices up to date as new studies come out.

Future Prospects

Looking ahead, methylamine shows no sign of disappearing from labs or factories. The march toward greener chemistry promises to deliver production routes less reliant on fossil fuel-derived feedstocks, perhaps even leveraging bio-based precursors to cut the carbon footprint. As regulations tighten around chemical precursors, compliance may become more demanding, driving new tracking and security features. Areas like battery technology and high-value pharmaceutical synthesis could push for ultra-pure methylamine, leading suppliers to raise their quality control game. Automation and remote monitoring, including AI-driven hazard prediction, stand ready to make handling safer and more predictable. All the while, the basics endure: careful handling, reliable supply, and a constant eye towards what’s next in science and regulation. The story of methylamine continues to evolve, just as chemistry itself manages to reinvent familiar compounds for a changing world.




What are the main uses of Methylamine (40 WT.% Solution in Water)?

Tackling the Practical Uses of Methylamine

Methylamine doesn’t show up in everyday headlines, but it keeps many essential industries running. It’s a simple molecule, one that brings a lot of value in its water-based form—a 40% solution is especially common for work in manufacturing. Life experience in a science lab teaches anyone pretty quickly that this solution is easier to handle than pure, gaseous methylamine, which is sharp, reactive, and quick to escape unless tamed by a watery partner.

Pharmaceuticals and Everyday Good Health

Many medications and vitamins depend on building blocks that only methylamine can offer. Years spent seeing pharmacy shelves get stocked shows how quietly crucial these chemical pieces are. It steps in early during the process, turning up in the synthesis of active pharmaceutical ingredients. Painkillers, antibiotics, and antihistamines often owe part of their structure to reactions that need methylamine’s unique traits. The water solution ensures safer transport and storage, which means less risk for people working around it.

Crop Protection and Fertilizer Manufacturing

No one wants to see a bad harvest ruin a season. Methylamine delivers for farmers and food producers by helping to create modern pesticides and herbicides. Behind many spray bottles labeled for farmland, methylamine has played a part. It helps tweak molecules so they hit the target pests without harming the crops. It also lends a hand in some nitrogen-based fertilizers, helping fields stay green and productive.

Resins, Plastics, and Everyday Essentials

Everyone interacts with plastics daily—food containers, car interiors, electronics. Factories need methylamine for certain resins, highly engineered plastics, and dyes that color them. I remember touring a manufacturing line where teams paid close attention to the precise blend of ingredients; methylamine’s watery form made it easier to mix and measure. This lowers the chance of a hazardous spill and keeps production running smoothly.

Water Treatment and Household Products

Cities and towns need clean water, and industry uses methylamine among other chemicals to keep supplies safe. It’s involved in the creation of some agents that prevent corrosion inside pipes, or that help bind together other important molecules during water purification. The modest 40% solution slips into this process without causing a fuss; that’s valuable in a field where reliability can’t slip.

Handling Risks and Looking for Safer Solutions

Methylamine brings plenty of positive uses, but its sharp ammonia-like smell and potential toxicity mean workers need to handle it with respect. Stories from seasoned plant operators show that careful training, airtight safety gear, and up-to-date facilities make the difference between a routine day and a dangerous spill. Technology continues to improve, with smart containment systems and detection monitors offering extra layers of protection. Those who’ve worked around chemicals know the smallest lapse in attention can cost dearly, which pushes companies to keep looking for safer, greener ways to do the same jobs methylamine does today.

Trust Earned through Expertise and Care

No one chemical solves every challenge, but methylamine’s 40% solution is wrapped up in a surprising number of daily products and basic services. The work done in labs and factories by people who understand what methylamine brings—and what can go wrong if it's mishandled—keeps society running more safely and smoothly than most ever realize.

What are the storage and handling requirements for Methylamine solution?

Understanding the Real Risks

Methylamine solution doesn’t give out a friendly warning when things start to go wrong. Left alone, the fumes build quickly, and a small leak in the right environment can turn serious fast. Those sharp, fishy smells aren’t just an annoyance—they’re a warning to take things seriously. Breathing in even moderate amounts can burn your nose and eyes, and if it splashes on bare skin, expect a sting.

I’ve worked in labs where one careless move with basic solvents set off every alarm. With methylamine, the concern ramps up because the solution catches fire more easily than water boils, and the vapors chase after sparks. There’s no room for shortcuts. The places storing these containers should always be cool, dry, and full of fresh air, not tucked under stairwells or near break rooms. Good air flow does more than lower the smell. It gets rid of buildup and cuts down on fire risk. Maintaining a storage temperature below 30°C sharply reduces accidents caused by over-pressurized containers on hot days.

Containers Matter

Skipping on container quality can undo every other effort. In practice, only high-density polyethylene, steel with special linings, or similar chemical-resistant materials hold up. I’ve seen a cheap plastic jug warp and fail in a single season, even though it looked just fine before filling. Screw-on caps lock up tightly, but always check for damage before tightening—hairline cracks let out fumes even faster than a missing lid. Forget about using glass in busy areas, since the risk of shattering bumps far outweighs any benefit. Labeling must stay sharp and complete, even after some drips and time on the shelf. Take time to double-check labels about concentration and hazard warnings—old handwritten tape doesn’t cut it when someone new comes on shift.

Handling Without Guesswork

Handling methylamine isn’t a job for improvisation. Personal protective equipment matters, even during quick transfers. Nitrile gloves, snug safety goggles, and a reliable lab coat stop most splashes from turning into medical emergencies. Moving bigger drums? Mechanical aids save more than backaches—they stop slips and container drops that can take down a whole operation. Only trained staff open and close these containers; a stray spark from a cell phone in someone’s pocket might touch off fumes. Grounding containers while pouring reduces the risk of static discharge. Don’t underestimate the power of regular spill response drills—they help teams catch small mistakes before they get expensive.

Fire Safety Isn’t Optional

Methylamine solution isn’t a chemical that forgives lazy fire prevention. Even a modest spill finds ignition from basic electrical sparks, pilot lights, or a cigarette left smoldering nearby. Installing chemical-rated fire extinguishers and sprinkler heads makes a real difference. Staff should know the nearest escape route late at night or after hours, since accidents don’t keep a regular schedule. Keeping incompatible chemicals separated matters as well—store acids far away, since mixing can give off clouds of toxic gas faster than anyone can react.

Building Good Habits

No regulation alone covers every risk, and simple routines often prevent a crisis. Daily checks for leaks, clear labels, real training sessions, and a tidy workspace have done more to keep teams safe than just following a set of rules. In my experience, groups that meet regularly to talk through close calls end up earning trust, reducing incidents, and handling emergencies with calm confidence. Mistakes get shared and learned from, not punished or covered up. In the long run, protecting people and property takes both discipline and the right culture, not just equipment and warnings on the wall.

What safety precautions should be taken when using Methylamine (40%)?

Keen Awareness Makes All the Difference

It doesn't take much to overlook a chemical’s power, especially one like methylamine at 40% concentration. Just thinking about its sharp ammonia-like smell triggers a personal memory: cleaning up after a minor spill in college research labs. Gloves on, vent running, headache for half a day. No need to experience that twice. Methylamine finds its way into agriculture, making herbicides, and even pharmaceutical syntheses, but the risks stick no matter the setting.

Skin and Eye Protection

Direct contact leaves skin red and raw, not unlike what acetone does after prolonged handling. Nitrile gloves offer real defense; latex doesn’t hold up as well. A good face shield or tight-fitting goggles keep stinging fumes and splashes at bay. I have seen a colleague rinse her eyes at an eyewash station, but anyone would want to avoid that altogether.

Ventilation and Air Quality

Breathing methylamine vapor feels harsh, like a whiff of ammonia squared. Fume hoods give lungs a break, so the vapors don’t gather. A standard lab fan isn’t enough. Indoor air quality monitors don’t lie – levels climb faster than expected, especially in closed rooms. Respirators with suitable cartridges push protection even further if exposure may last.

Storage Cautions

This isn’t a bottle to leave under a bench. It corrodes metal, especially copper, and light plastics can give way too. Glass or high-grade HDPE bottles screw tight enough to hold up. I always check labels and stoppers, since leaks seem to appear right before regular inventory days.

Spill Management

Spills never fit a neat script. Sure, lab manuals walk through steps, but real messes tend to spread fast. Neutralizers like citric acid or sodium bicarbonate slow the fumes, but paper towels don’t cut it. Rags and absorbent pillows make cleanup safer—real back-saver for anyone nearby. Disposing of towels means sealing them until the waste team can take over. I’ve found that skipping over this step stirs up trouble the next day.

Fire and Explosion Risks

Methylamine lights up easily and forms flammable mixes with air. Forgetting this means ordinary switches or heat sources become hazards. Using spark-proof tools turns near-misses into non-events. Fire blankets and extinguishers meant for chemicals aren’t just props. During one drill, we counted every second, and realized grabbing the wrong extinguisher wasted precious time.

Emergency Preparedness

Practicing safety drills sounds like overkill until sirens sound for real. Emergency showers, eyewashes, and proper exits—the basics—need regular checks. I always walk new team members through the route, so no one fumbles reaching them. Emergency contact numbers and clear labels save time. Sometimes, simple signage makes the biggest impact during chaos.

Records, Training, and Community Responsibility

Documented training, even repeated every year, helps everyone take chemicals like methylamine more seriously. Material Safety Data Sheets (MSDS) aren’t just paperwork. They outline reaction hazards, symptoms, and treatment steps—details easy to forget under stress. Sharing hard-won lessons at safety meetings, and not hiding near-misses, builds trust. This turns one person’s slip into a lesson for the entire crew.

How should spills or exposure to Methylamine solution be managed?

Recognizing the Risks

Methylamine solution pops up in many industrial uses, from the pharmaceutical sector to the production of pesticides and solvents. This chemical carries real hazards you can’t sweep under the rug—breathing it in or letting it touch your skin stings and burns, and large spills can spread fumes fast. Having worked around chemicals for years, I know a few seconds of hesitation can make all the difference. Keeping safety front and center matters a lot more than hoping things will go right.

Immediate Steps Matter More Than Protocol Paperwork

Spills or exposure in a real-world setting typically demand action fast. Once that container leaks or tips over, the clock starts ticking. Grab a proper respirator and chemical-resistant gloves before anything else. Eyes and airways feel the effects straight away, so goggles and well-fitted masks become your best friends.

Deal with the source first. If you spot a slowly tipping drum, upright it if possible—just don’t compromise your own safety. No chemical is worth a trip to the ER. Try to move people out of the affected area; ventilation should come next. Open doors and windows wide, kick on any local exhaust hoods, and keep the air moving away from you, not toward your coworkers.

Control and Clean Up—the Right Way

Small spills need a quick cover with something to soak up the liquid, like absorbent pads meant for caustic chemicals. You want to avoid anything reactive—no sawdust or paper towels, or you’ll make the situation worse. Scoop that material up fast and drop it into a sealed, clearly marked container for hazardous waste. Larger spills mean you’re calling the hazardous materials team. Don’t play the hero—chemicals can get nasty in seconds, with fumes triggering coughs, headaches, or even bigger health hits.

If skin or eyes meet methylamine solution, head for the safety shower or eyewash station. Get clothing off right away, flush with water for at least fifteen minutes, and don’t bother trying shortcuts. Call medical help in, as burns and lung irritation can show up later. Take it from anyone who’s faced chemical burns—they’re nothing to mess around with.

Facts and Fixes From Real Experience

Numbers from government agencies like OSHA put methylamine on the watchlist for good reason. Just a few parts per million in the air can cause significant irritation. Facilities often rely on personal protective equipment and clear labeling to dodge these risks. In my time on-site, regular drills and honest conversations made the biggest difference—everyone knows where the shower is, how to use spill kits, and whom to call when things go bad.

Solutions start with training. Safety isn't just about a checklist; it's about knowing you can trust those around you to move quickly, not panic, and remember the basics. Good signage at sink stations, refresher training sessions, and a culture where workers feel safe to speak up about spills—those simple efforts beat expensive tech any day.

Leaving No Room for Complacency

Spills and exposure can’t always be predicted—someone might trip, a fitting might fail. Still, workers should keep the basics in mind: suit up, stay alert, and don’t tackle bigger spills solo. Clean-up teams should get regular hands-on practice, not just theory. Companies should resist the urge to cut corners on personal protective gear or stash spill kits out of sight to save warehouse space. The lesson’s clear: careful handling and quick response are built on habits, not chance.

What is the shelf life and recommended storage temperature for Methylamine (40 WT.% Solution in Water)?

Methylamine Solution: Stability Depends on Proper Storage

Methylamine in a 40% water solution is known for its uses in both commercial labs and chemical manufacturing. The stability of this solution depends heavily on storage practices. Storing methylamine correctly isn’t just about ticking boxes. Everyone in the lab cares about maintaining quality—and safety.

Why Storage Conditions Matter

Anyone who has spent time around volatile chemicals knows the routine—cool, dry, well-ventilated. Losing sight of that, even for one shipment or one bottle, can mean a compromised reagent. Water-based methylamine solution works for a variety of syntheses because it remains stable under the right conditions. Excess heat speeds up decomposition, which in turn increases pressure inside containers, risking leaks or more severe incidents. Safety data sheets from major chemical suppliers point to a shelf life between 12 and 24 months, but only under good storage habits.

Shelf Life: The Details Behind the Number

Twelve to twenty-four months sounds straightforward, but that’s not guaranteed in busy labs where temperature and ventilation aren’t maintained. Keep methylamine solution in tightly sealed, corrosion-resistant containers. The ideal temperature range sits between 2°C and 8°C, the sweet spot for many lab reagents. Using plastic-coated glass or specific chemical-resistant plastics helps avoid reaction with container material.

Exposure to direct sunlight, fluctuating temperatures, or contaminated dispensing tools starts a chain reaction of degradation. Anyone who’s worked with aging stock solutions knows the telltale scent—fishy, overpowering, and stronger than when new. Visual checks also help; cloudiness or any phase separation serves as a red flag.

Consequences of Poor Storage—Anecdotes from the Bench

A few years working with methylamines, you start to hear the same warnings. I’ve seen researchers discover weakened methylamine reactivity halfway through an organic synthesis, only to backtrack and discover sun-warmed storage led to partial evaporation and contamination. Not only does that waste time, but redoing procedures racks up unnecessary costs.

Facing the Real-World Challenges

Many labs stretch out chemical budgets. Extending shelf life starts with basic discipline—consistent refrigeration (2°C to 8°C), proper sealing after every use, and regular rotation of inventory. Installing thermometers in chemical storage fridges makes it easier to spot temperature spikes before they turn into bigger problems. Logging bottle opening dates helps track how long a given stock remains on the shelf. It’s a simple routine, but it saves frustration down the road.

Supporting Data and Guidance

Sigma-Aldrich and Thermo Fisher publish product guidance that recommends this same temperature range and storage away from oxygen and incompatible compounds. Methylamine remains relatively stable as long as the water doesn’t evaporate and the solution gets handled with fresh, clean tools. In major spills, evaporation releases methylamine gas, a known irritant—so proper storage also protects health.

Better Practices, Better Results

Labs can extend reagent shelf life by assigning storage responsibility, checking expiration dates, and retraining new hires in chemical hygiene. Opening a fresh bottle of methylamine comes with a distinct smell and clarity; later, if it looks off or has an unexpected odor, replacement beats risk any day. Working with volatile organics means the margin for error isn’t wide, so treating storage like a key part of the workflow keeps experiments safe and productive.

Methylamine (40 WT.% Solution in Water)
Names
Preferred IUPAC name Methanamine
Other names Methylamine, aqueous solution
Methanamine solution
Aminomethane solution
Pronunciation /ˈmɛθ.ɪlˌæm.iːn/
Identifiers
CAS Number 593-51-1
Beilstein Reference 635910
ChEBI CHEBI:18257
ChEMBL CHEMBL1237
ChemSpider 8657
DrugBank DB03761
ECHA InfoCard 03-2119457568-37-0003
EC Number 200-820-0
Gmelin Reference 828
KEGG C00240
MeSH D008767
PubChem CID 6329
RTECS number PD0175000
UNII GQK102HN3S
UN number UN1237
Properties
Chemical formula CH5N
Molar mass 31.06 g/mol
Appearance Colorless to slightly yellow liquid
Odor fishy
Density 0.945 g/mL at 25 °C
Solubility in water Miscible
log P -0.57
Vapor pressure 17.3 kPa (at 20 °C)
Acidity (pKa) 10.66
Basicity (pKb) 3.35
Magnetic susceptibility (χ) -9.0×10⁻⁹ cm³/mol
Refractive index (nD) 1.372
Viscosity 0.7 mPa·s (20 °C)
Dipole moment 1.31 D
Thermochemistry
Std molar entropy (S⦵298) 85.8 J/mol·K
Std enthalpy of formation (ΔfH⦵298) -57.2 kJ/mol
Std enthalpy of combustion (ΔcH⦵298) -889.6 kJ/mol
Pharmacology
ATC code V03AB33
Hazards
GHS labelling GHS02, GHS05, GHS06
Pictograms GHS02,GHS06
Signal word Danger
Hazard statements H226, H301, H311, H314, H331
Precautionary statements Precautionary statements for Methylamine (40 WT.% Solution in Water): "P210, P233, P260, P264, P271, P273, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P363, P370+P378, P391, P403+P235, P405, P501
NFPA 704 (fire diamond) 3-4-2-W
Explosive limits 4.9% (LEL) – 20.7% (UEL)
Lethal dose or concentration LD50 Oral Rat 2,130 mg/kg
LD50 (median dose) LD50 Oral Rat 2,400 mg/kg
NIOSH MW6125000
PEL (Permissible) PEL = 5 ppm (skin)
REL (Recommended) REL (Recommended Exposure Limit) for Methylamine (40 WT.% Solution in Water) is: `"10 ppm (8-hour TWA)"`
IDLH (Immediate danger) 100 ppm
Related compounds
Related compounds Ammonia
Ethylamine
Dimethylamine
Formamide
Methylammonium chloride