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Name: Methyl-β-Cyclodextrin, Cell Culture Grade
Chemical Formula: C42H70-n(CH3)nO35
Physical Form: Fine, white to off-white powder, odorless and tasteless
Synonyms: Methylated beta-cyclodextrin
Intended Use: Laboratory chemical, used widely in cell culture to manipulate cholesterol content of biological membranes
Classification: Not classed as hazardous under current GHS (Globally Harmonized System)
Routes of Entry: Inhalation, ingestion, contact with skin or eyes
Potential Effects: Dust can irritate eyes, skin, or respiratory system; ingesting large amounts brings gastrointestinal upset
Lab Considerations: Prolonged or repeated exposure to dust forms may aggravate preexisting respiratory conditions; minimize dust generation
Main Component: Methylated beta-cyclodextrin at highest available purity
Impurities: May include trace sodium or potassium as counter ions, water content below one percent
CAS Number: 128446-35-5 for methyl-β-cyclodextrin
Inhalation: Move person to fresh air immediately; seek medical help if breathing becomes labored or does not return to normal
Skin Contact: Wash affected area with soap and water; remove contaminated clothing
Eye Contact: Rinse cautiously with water for several minutes; lift eyelids to ensure thorough flushing
Ingestion: Rinse mouth with water; do not force vomiting; call a healthcare provider if feeling unwell after swallowing
Flammability: Organic powder, can burn but doesn’t ignite readily at room temperature
Suitable Extinguishers: Water spray, dry chemical, carbon dioxide, foam
Special Hazards: Burning generates carbon oxides (CO, CO2) and possibly methyl ethers; dense smoke expected
Protective Equipment: Wear self-contained breathing apparatus with full protective gear; stay upwind
Explosion Risk: Dust suspended in air could form explosive mixtures, common to most fine organic powders
Personal Precautions: Wear nitrile gloves, lab coat, safety glasses or goggles, particle mask if dust develops
Environmental Precautions: Prevent material from washing to drains or surface water; gather powder with care
Spill Cleanup: Sweep up using methods minimizing dust; transfer to suitable waste container; ventilate area well
Handling: Minimize dust production; work in fume hood or ventilated space; never eat, drink, or smoke in use areas
Storage: Keep tightly sealed in original container; store in cool, dry, and ventilated area, protected from light and humidity
Incompatible Materials: Strong oxidizing agents and strong acids; keep away from sources of ignition
Ventilation: Local exhaust recommended for regular handling
Personal Protective Equipment: Laboratory gloves (nitrile preferred), splash-resistant lab coat, protective eyewear
Work Hygiene: Wash hands thoroughly after use; avoid touching face during handling
Respiratory Protection: Use dust mask if powder becomes airborne
Engineering Controls: Use non-sparking tools, keep containers closed when not in use
Appearance: White or nearly white powder
Odor: Virtually none
Melting Point: Decomposes before melting at elevated temperature above 210°C
Solubility: Dissolves in water, forms clear to slightly opalescent solutions
pH (1% in water): Neutral to slightly alkaline
Bulk Density: Moderate, flows easily if kept dry
Stability: Chemically stable under recommended storage and handling
Hazardous Reactions: Rapid oxidation with strong oxidizers
Decomposition Products: Releases CO, CO2, possible methyl ethers on combustion or thermal decomposition
Reactivity: Inert to most laboratory reagents, apart from strong acids and oxidants
Acute Toxicity: Low oral toxicity in laboratory animals
Routes of Exposure: Inhalation, ingestion, skin absorption unlikely
Chronic Effects: No chronic toxicity observed in studies at cell culture concentrations
Carcinogenicity: Not listed as carcinogen by IARC, NTP, or OSHA
Sensitization: No evidence of allergic response under intended use
Environmental Fate: Expected to biodegrade in soil and water over time
Bioaccumulation: Low potential due to high water solubility and biological degradability
Aquatic Toxicity: No documented harm at low concentrations, but wastewater treatments help prevent excess chemical build-up
Method: Place waste in labeled chemical container; follow local rules for laboratory chemical waste
Do Not: Discharge large quantities to drain or the environment
Rationale: Responsible disposal protects both municipal water sources and the broader ecosystem
UN Number: Not regulated for ground, air, or sea transport
Packaging: Ship in sealed containers preventing moisture uptake, labeled with chemical identity
Transport Hazards: Routine care to avoid package breakage; no special transport conditions required for standard laboratory quantities
Government Listings: Not subject to chemical-specific federal, state, or international restrictions for common laboratory use
Occupational Restrictions: Basic lab safety training recommended
Labeling: Clear labeling with hazard and precautionary information supports safe workplace practice
Medical Surveillance: Not required for professionals handling methyl-β-cyclodextrin at typical exposure levels
