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Product Name: Methanol-D4
Chemical Formula: C1D4O
CAS Number: 811-98-3
Synonyms: Deuterated methanol, Methanol-4D
Recommended Uses: Laboratory reagent, solvent in NMR spectroscopy
Manufacturer Contact Information: Safety or regulatory affairs department with a 24-hour emergency response phone number
Classification: Flammable liquid, toxic if inhaled or swallowed, causes organ damage after prolonged or repeated exposure
Hazard Symbols: Flame, Skull and Crossbones, Health Hazard (GHS 02, GHS 06, GHS 08)
Signal Word: Danger
Hazard Statements: Highly flammable liquid and vapor, toxic if swallowed, causes serious eye and respiratory irritation, may cause drowsiness or dizziness, may cause damage to organs including optic nerve, liver, kidney, and central nervous system
Precautionary Statements: Keep away from heat, sparks, open flames; avoid breathing vapors; wear protective gloves, clothing, and eye protection
Chemical Name: Methanol-D4
Purity: Typically 99% or higher deuterium content
Impurities: Trace water, undeuterated methanol
Component Range: No significant additives, single component of concern
Molecular Weight: 36.07 g/mol
Inhalation: Remove person to fresh air immediately; provide oxygen if breathing is difficult; seek medical attention for persistent symptoms
Skin Contact: Remove contaminated clothing; wash skin thoroughly with soap and water; seek medical advice if irritation persists
Eye Contact: Flush eyes gently with plenty of water for at least fifteen minutes, lifting upper and lower eyelids occasionally; obtain prompt medical attention
Ingestion: Do not induce vomiting; rinse mouth with water; seek medical evaluation right away; if individual feels drowsy or confused, transport to hospital without delay
Indications for Immediate Medical Attention: Exposure may affect nervous system; consult poison control or physician for methanol toxicity protocol
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical, carbon dioxide, water spray
Specific Hazards: Vapors can form explosive mixtures with air; fire vapors may travel and ignite at distant points
Special Protective Actions: Firefighters should wear self-contained breathing apparatus and full protective gear
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, deuterium oxide
Additional Instructions: Cool surrounding containers with water spray to prevent ignition or pressure buildup; avoid inhaling smoke
Personal Precautions: Evacuate unnecessary personnel, ventilate area, eliminate ignition sources, wear appropriate protective equipment
Environmental Precautions: Prevent spillage from reaching sewers, waterways, or soil; notify relevant authorities if contamination occurs
Cleanup Methods: Absorb with non-combustible absorbent (sand, earth, vermiculite), transfer to suitable closed container for disposal
Decontamination: Wash area with water after material removal, ventilate area further
References for Emergency Response: Consult local emergency plan and follow spill response protocol
Safe Handling: Work in well-ventilated spaces, avoid inhalation and skin or eye contact, keep containers tightly closed
Storage Conditions: Store away from sources of ignition in approved flammable-liquid storage facilities, maintain at room temperature or as specified
Incompatible Materials: Strong oxidizers, acids, alkali metals, acid chlorides, acid anhydrides
Special Storage Requirements: Use flame-proof and explosion-proof electrical equipment; clearly label all containers
Hygiene Measures: Avoid eating, drinking, or smoking in storage or working areas; wash hands after handling
Exposure Limits: OSHA PEL (TWA): 200 ppm (methanol), ACGIH TLV (TWA): 200 ppm
Engineering Controls: Use chemical fume hood or mechanical exhaust; ensure eyewash and safety shower are readily accessible
Personal Protective Equipment (PPE): Nitrile gloves, chemical splash goggles, face shield, protective lab coat
Respiratory Protection: Use approved respirator if ventilation inadequate
Other Protection: Remove contaminated clothing, wash before reuse, keep emergency escape mask available in high-risk settings
Appearance: Clear, colorless liquid
Odor: Mild alcohol-like, slightly less pungent due to deuterium
Boiling Point: ~65-66°C (149-151°F)
Melting Point: -98°C (-144°F)
Flash Point: 11°C (52°F) (closed cup)
Vapor Pressure: 100 mmHg at 20°C
Density: 0.885 g/cm³ at 20°C
Solubility: Fully miscible with water and organic solvents
Partition Coefficient (n-octanol/water): -0.77
pH: Not applicable (neutral in solution)
Chemical Stability: Stable under normal laboratory and storage conditions
Reactivity: Reacts vigorously with oxidizing agents, may react with strong acids or alkali metals
Conditions to Avoid: Heat, sparks, open flames, static discharge
Hazardous Decomposition Products: Toxic fumes of carbon monoxide, carbon dioxide, formaldehyde
Polymerization: No hazardous polymerization expected
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Toxic if swallowed or inhaled; LD50 (oral, rat): 5628 mg/kg (methanol), similar for Methanol-D4
Chronic Effects: Liver and kidney damage, blindness, central nervous system toxicity
Symptoms: Drowsiness, headache, nausea, vomiting, visual disturbances, respiratory difficulty
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Mutagenicity / Teratogenicity: May affect fertility and cause developmental toxicity at high exposures
Sensitization: No known sensitization reported
Aquatic Toxicity: Harmful to aquatic life in high concentrations; LC50 (fish, 96 hr): >15,400 mg/L (methanol)
Persistence and Degradability: Rapidly biodegradable under environmental conditions, low potential for bioaccumulation
Mobility in Soil: High mobility due to high solubility, likely to leach into groundwater
Other Adverse Effects: Deuterated compounds may persist slightly longer but are not expected to greatly impact the environment compared to normal methanol
Waste Disposal Methods: Dispose as hazardous waste in compliance with local, state, and federal regulations; transfer to licensed chemical disposal company
Container Disposal: Triple rinse and puncture before disposal, ensure all residuals are removed
Precautions for Disposal: Do not pour down drain; do not burn or incinerate waste in open environment
Handling of Contaminated Packaging: Decontaminate containers before recycling or final disposal
UN Number: 1230
Proper Shipping Name: Methanol
Hazard Classification: 3 (Flammable liquid), 6.1 (Toxic substance)
Packing Group: II
Labels Required: Flammable liquid, Toxic
Special Provisions: All shipments must comply with applicable IATA, IMDG, and DOT rules; use approved containers and markings
OSHA: Classified hazardous; subject to OSHA Process Safety Management
TSCA: Listed on Toxic Substances Control Act inventory
SARA Title III: Methanol subject to reporting under Section 313
California Proposition 65: Methanol listed for developmental toxicity
WHMIS (Canada): B2, D1B, D2B (flammable, toxic, irritant)
REACH (Europe): Substance registered, follows all EC regulations on manufacture and import; ensure local compliance for safety data reporting
