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Product Name: L-Leucine
Chemical Formula: C6H13NO2
Synonyms: 2-Amino-4-methylpentanoic acid
CAS Number: 61-90-5
Recommended Use: Amino acid, food additive, laboratory research
Supplier Name: Refer to container label or invoice for sourcing information
Contact Information: Safety department or responsible company representative, include emergency phone contact for quick advice
Product Description: White, crystalline powder; commonly used in laboratories, supplement manufacturing, and as a nutritional additive.
Classification: Not classified as hazardous according to GHS guidelines
Physical Hazards: No significant risks from a physical hazard standpoint; not flammable in ordinary settings
Health Hazards: May cause mild skin or eye irritation on direct exposure; inhaling dust can trigger irritation to respiratory tract
Environmental Hazards: Considered low hazard to the environment in normal laboratory or industrial use
Signal Word: Not required as L-Leucine’s risk is minimal
Hazard Statements: Respirable dust may induce mechanical irritation; not known for chronic effects
Pictogram: None required per international rules
Precautionary Statements: Prevent contact with eyes and skin; avoid inhaling fine dust.
Chemical Identity: L-Leucine
Purity: Typically >98%
Impurities: May contain trace elements below regulatory thresholds, most batches reported as free of significant contaminants
Component: L-Leucine is a single-component material; not a blend or compound mix
EC Number: 200-522-0
Formula Representation: C6H13NO2 as standard for scientific protocols
Inhalation: Move person to fresh air; use artificial respiration if breathing stops; seek medical evaluation for prolonged irritation
Skin Contact: Wash thoroughly with soap and running water. Remove contaminated clothing; seek medical help for persistent irritation
Eye Contact: Rinse with water for at least 15 minutes, keeping eyelids open; seek out medical attention if redness or discomfort stays
Ingestion: Rinse mouth out; get medical advice if large quantities were swallowed or symptoms develop
Notes for Physicians: L-Leucine is not highly toxic; treatment is supportive based on symptoms
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, foam, or water spray—choose the best option for burning surroundings
Special Protective Equipment: Standard firefighting gear including NIOSH-approved self-contained breathing apparatus; life is always more important than property
Hazardous Combustion Products: Fumes can emit carbon oxides (CO, CO2) and nitrogen oxides at high temperatures
Fire and Explosion Hazards: Material on its own does not readily burn but fine dust in air may rarely pose a risk
Advice for Firefighters: Avoid inhaling smoke; cool exposed containers with water spray to prevent rupture
Personal Precautions: Shield yourself with gloves and goggles; avoid breathing airborne dust. Use proper ventilation
Environmental Precautions: Prevent runoff into drains or natural waterways—never assume “benign” means harmless in the wild
Spill Cleanup Methods: Scoop up mechanically; avoid generating airborne dust; use HEPA vacuum or moistened material for small spills. Dispose as required by local rules
Preventive Steps: Block off area for large releases; tell coworkers about the hazard and wear protective gear
Handling: Use gloves, safety goggles, and a dust mask. Pour and weigh out powder in a ventilated workspace. Handle container carefully to avoid spillage
Storage Conditions: Store in tightly closed container; keep in a cool, dry place, away from direct sunlight, incompatible substances (strong oxidizers), and moisture
Hygiene Advice: Wash hands after handling; don’t eat or drink in work area; keep away from food prep zones.
Occupational Exposure Limits: No established OSHA or ACGIH limits, though workplace monitoring for dust is wise in bulk settings
Engineering Controls: Local exhaust for lab use, dust extraction for bigger batches
Personal Protective Equipment: Safety glasses or goggles; light protective gloves (nitrile or latex); certified dust mask or respirator if frequent dust exposure occurs; lab coat and closed footwear
General Safety Measures: Wash hands with soap post-use; keep work clothing separate from home items
Appearance: White crystalline or fine powder
Odor: No distinct smell
pH (5% solution): Close to neutral (5.5–7.0)
Melting Point: About 293°C (decomposes)
Boiling Point: Not applicable; decomposes before boiling
Solubility: Moderately soluble in water; limited solubility in organic solvents
Density: About 1.293 g/cm³
Vapor Pressure: Negligible at room temperature
Other Properties: Non-flammable, not explosive under standard conditions
Chemical Stability: Stable in typical laboratory and warehouse environments when dry
Conditions to Avoid: Prolonged air exposure, high humidity, and strong direct sunlight
Incompatibility: Strong oxidizers; keep separated to prevent unwanted reactions
Decomposition Products: Emits carbon oxides and nitrogen oxides if heated strongly or incinerated
Polymerization: No risk for hazardous polymerization in storage or use
Acute Toxicity: Not known to be acutely toxic; high oral doses may cause gastrointestinal upset in people and animals
Skin/Eye Irritation: Can cause mild irritation on prolonged exposure
Sensitization: Not classified as an allergen
Chronic Toxicity: No credible human data linking chronic exposure to health effects
Mutagenicity, Carcinogenicity: Not classified as mutagenic or carcinogenic by IARC, NTP, or OSHA
Notes: Safe to handle with general precautions; data stems from lab and nutritional research
Ecotoxicity: In standard practices, not expected to harm aquatic or terrestrial life
Persistence and Degradability: Biodegradable over moderate timescales; not persistent
Bioaccumulation Potential: Low risk due to rapid breakdown in environment
Mobility: Can leach in soils but breaks down in natural waters by microbial action
Aquatic Precautions: Avoid deliberate disposal into open water
Product Disposal: Treat as regular laboratory solid waste unless local rules dictate stricter handling
Contaminated Packaging: Empty thoroughly; rinse before recycling; packaging can often go with normal waste after decontamination
Preferred Methods: Incineration in an approved facility; landfill disposal under proper supervision
Regulatory Advice: Always check community-specific requirements; regulations change by country and region
Shipping Classification: Not a hazardous material for transport by road, rail, air, or sea (DOT, IATA, IMDG, ADR)
Proper Shipping Name: L-Leucine
UN Number: Not assigned
Packing Group: Not applicable
Labels Required: None for ground, air, or marine movement
Special Precautions: Ship in closed containers; avoid rough handling to prevent package rupture and powder spread
GHS Classification: Not hazardous
TSCA Status: Listed in U.S. Toxic Substances Control Act inventory
REACH Status: Registered under Europe’s chemical safety system; no known restrictions
SARA Title III: Not listed as a reportable material under EPA rules
California Proposition 65: Not present on carcinogen or reproductive toxin list
Other Local Regulations: Always check latest national, state, and municipal codes, especially for bulk use, waste, and workplace ventilation requirements
